Lymphocytic-Plasmacytic Enteritis in 24 Dogs

Jacobs, G; Collins‐Kelly, Lynda; Lappin, Michael R.; Tyler, D. E.

doi:10.1111/j.1939-1676.1990.tb00875.x

Cited by 55 publications

(28 citation statements)

References 8 publications

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“…In a previous study on Shiba dogs with CE, the median age was 4.9 years [6], which was almost comparable to the ages reported in other retrospective studies of dogs with IBD and CE [10-12]. Similarly, in our study, the median age of the Ls group was 5 years (mean 5.2).…”

Section: Discussionsupporting

confidence: 89%

“…In a previous study on Shiba dogs, the median survival was 74 days, and the survival rates at 6 months and 1 year were 46% and 31%, respectively [6]. In the other reports on dogs with IBD and LPE, which included several breeds, the survival rates at 6 months were 96% and 74%, respectively [8,12]. Compared to these reports, our findings strongly suggest a poor outcome for Shiba dogs with CE.…”

Section: Discussionsupporting

confidence: 43%

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The characteristics of short- and long-term surviving Shiba dogs with chronic enteropathies and the risk factors for poor outcome

et al. 2013

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BackgroundThe objectives of this study were to investigate the differences in the characteristics of short- and long-term surviving dogs, and the factors that predict poor outcome in Shiba dogs with chronic enteropathies (CE).MethodsA total of 25 Shiba dogs were included in this study, and classified as either short-term (≤6 months) survivors (Ss; n=16) or long-term (>6 months) survivors (Ls; n=9). The clinical and clinicopathological variables, histopathology, response to therapy, and outcomes were investigated between groups. Furthermore, these factors were tested for their ability to predict poor outcome.ResultsAll CE dogs were diagnosed as having inflammatory bowel disease (IBD) with lymphocytic-plasmacytic enteritis (LPE). Age and canine inflammatory bowel disease activity index (CIBDAI) were significantly higher in the Ss group than in the Ls group (age: p = 0.035, CIBDAI: p = 0.018), as determined via univariate logistic regression analysis. According to receiver operator characteristic (ROC) curve analysis, the best predictors of poor outcome were age and CIBDAI, with the cutoffs determined as 7 years and 9 points, respectively. The majority of the cases (84%) responded to initial treatment; in particular, 75% of dogs in Ss group responded to therapy. The time to response (days) to the initial treatment in the Ss group (median 42.5 days, range: 20-91 days) was significantly shorter than that of the Ls group (median 285 days, range: 196-1026 days). Approximately half (55.5%) of the dogs in the Ls group died due to relapse of CE.ConclusionsThis study suggested that there is a high risk of early mortality in Shiba dogs with CE, particularly if the dogs are older (>7 years) and have a high CIBDAI score (>9 points). There appears to be a possibility of early mortality even if the initial treatment was efficacious. Furthermore, Shiba dogs with CE that become less responsive to initial therapy in the short-term (approximately 3 months) are more likely to have an early mortality. Thus, it is necessary to follow-up Shiba dogs with CE in the long-term, as approximately half of the long-term survivors eventually died due to a relapse of the signs.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 43%

The characteristics of short- and long-term surviving Shiba dogs with chronic enteropathies and the risk factors for poor outcome

et al. 2013

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“…Previous studies reported a higher prevalence of hypoproteniemia in these LPE dogs compared to our study, ranging from 24~63% [3,13,14,21]. It is unclear why the LPE dogs in the present study had a lower prevalence of hypoproteinemia compared to previous studies.…”

Section: Discussioncontrasting

confidence: 83%

White spots on the mucosal surface of the duodenum in dogs with lymphocytic plasmacytic enteritis

et al. 2011

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Distended lacteals, described as expanded white villi in duodenum, are strongly indicative of primary intestinal lymphangiectasia. In the present study, we evaluated the significance of white spots present in the duodenal mucosa of dogs with lymphocytic plasmacytic enteritis (LPE). Fifty dogs with LPE were included in this study, and white spots were detected in the duodenal mucosa in 22 dogs during endoscopy. Hypoproteinemia was more frequent in dogs with white spots than in dogs without spots (p = 0.02). Serum protein and albumin concentration were significantly lower in LPE dogs with white spots (p = 0.038) compared to LPE dogs without white spots (p = 0.039). There was a significant correlation between white spots density and lymphatic dilatation histological scores (p = 0.023; ρ = 0.481). These results suggest that the presence of white spots in the duodenal mucosa of dogs is not a finding exclusive for intestinal lymphangiectasia. Low serum protein and albumin concentrations together with lymphatic dilatation seem to be related to the presence of white spots in the duodenal mucosa of LPE dogs.

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“…Canine enteropathies may be multifocal in distribution, 1–3 which favors collecting biopsy samples from more than 1 anatomical location. Taking samples of ileal mucosa, however, is not a routine procedure.…”

mentioning

confidence: 99%

Comparison of Histopathologic Findings in Biopsies from the Duodenum and Ileum of Dogs with Enteropathy

Casamian‐Sorrosal

Willard

Murray

et al. 2010

Veterinary Internal Medicne

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Background: In the investigations of dogs with chronic small intestinal diarrhea collection of ileal biopsies lengthens procedural time and has been of uncertain value.Objectives: To evaluate whether there was agreement between histologic changes present in samples of duodenal and ileal mucosa, and hence to provide initial information in the process of determining whether collection of ileal biopsies is clinically justified.Animals: 40 dogs with chronic small and large intestinal diarrhea from which endoscopic (in 30 cases) or surgical (in 10 cases) duodenal and ileal biopsies had been collected.Methods: Samples were reviewed concurrently by two observers (MJD and MDW) using the scoring system developed by the World Small Animal Veterinary Association (WSAVA) Gastrointestinal Standardization Group. Comparisons were made by kappa analysis.Results: Microscopic pathology was observed in 30 cases. Only eight out of this 30 (27%) had the same histopathologic diagnosis in both the duodenum and the ileum. This dropped to 3 out of 30 (10%) if different disease severity was also considered as disagreement. Microscopic pathology would have been found in 60% and 80% of the 30 cases, if only duodenal or ileal biopsies respectively, had been available.Conclusions and clinical importance: There was poor agreement between histopathological findings from duodenal versus ileal biopsies with abnormalities sometimes being more readily detected in the ileum. Routine collection of ileal plus duodenal samples appears warranted when concurrent small and large intestinal diarrhea is present.

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Lymphocytic-Plasmacytic Enteritis in 24 Dogs

Cited by 55 publications

References 8 publications

The characteristics of short- and long-term surviving Shiba dogs with chronic enteropathies and the risk factors for poor outcome

The characteristics of short- and long-term surviving Shiba dogs with chronic enteropathies and the risk factors for poor outcome

White spots on the mucosal surface of the duodenum in dogs with lymphocytic plasmacytic enteritis

Comparison of Histopathologic Findings in Biopsies from the Duodenum and Ileum of Dogs with Enteropathy

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