Lymphocytopoiesis in the bursa of Fabricius

Ackerman, G. Adolph; Knouff, Ralph A.

doi:10.1002/aja.1001040202

Cited by 128 publications

(51 citation statements)

References 9 publications

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“…At a later stage stem cells leave the yolk sac and migrate into the primordia of other hemopoietic tissues (54). They appear in the bursa of Fabricius on the 14th-15th d of incubation (55). However, Ewald et al (56) found only 9.3% of rosette forming lymphocytes in the bursa of 15-d-old embryos and none in the spleen, bone marrow, or thymus.…”

Section: Xenotransplantation Of Embryonic Endocrine Pancreas In the Ratmentioning

confidence: 99%

Chick embryo pancreatic transplants reverse experimental diabetes of rats.

Eloy¹,

Haffen²,

Kédinger³

et al. 1979

J. Clin. Invest.

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A B S T R A C T The effectiveness of xenogeneic embryonic tissue in the treatment of experimental diabetes has been investigated in rats. The splenic lobes (80) of 15-to 18d-old chick embryos, composed almost exclusively of endocrine tissue, were implanted directly into the hepatic parenchyma of the rat recipient. The biochemical and metabolic changes in the recipients suggest that embryonic transplants of 15-d-old chick pancreases were able to significantly improve, for a prolonged period of time (18 mo), the diabetic state of nonimmunosuppressed rats. None of the recipients of 18-d-old embryos splenic lobes exhibited a long-term improvement ofthe diabetic state after transplantation. The complete destruction of the pancreatic B cells of the recipients was asssessed by: (a) immunocytochemical investigations of the recipient's pancreas, (b) measurement of insulin in the liver and pancreas of the recipients and (c) in situ vascular perfusion of their pancreas submitted to high glucose challenge. The results suggest that pancreatic tissue of the 15-d-old embryos is immunologically immature lacking one or several lymphocyte subsets implicated in the afferent loop of "non-self" recognition.

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Section: Xenotransplantation Of Embryonic Endocrine Pancreas In the Ratmentioning

confidence: 99%

Chick embryo pancreatic transplants reverse experimental diabetes of rats.

Eloy¹,

Haffen²,

Kédinger³

et al. 1979

J. Clin. Invest.

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“…In their study on the bursa of Fabricius in the chicken, ACKERMAN and KNOUFF (1959) reported: "These blast cells appear to be formed intraepithelially and the possibility of their arising from mesenchymal cells in the tunica propria and migrating were first found in the tunica mucosa at 8 days' incubation. The first appearance of the lymphoid cells in the epithelium was 1.5 days after that in the tunica mucosa.…”

Section: Resultsmentioning

confidence: 99%

Mesenchymal Origin of Bursal Lymphoid Cells in Japanese Quails

Yamada

Sugimura

Kudo

1975

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In some follicles of 6-month-old chickens, where the division in cortex and medulla was still visible, rare cortical cells were still positive for these enzymes. Azan-Mallory stain and the ATP-ase reaction pictured vessels only in the cortex and in the collagenous space between cortex and medulla, confirming the absence of vascularization of the medulla (Jolly, 1914;Ackerman and Knouff, 1959).This particular distribution was supposed to constitute a blood-bursa barrier (Davenport and Allen, 1995).…”

mentioning

confidence: 89%

“…The apical part of these cells contained PAS-positive secretory material (Ackerman and Knouff, 1959;Bockman and Cooper, 1973;Betti, 1989). Romano et al (1996), in ultrastructural studies, have also described an undifferentiated type cell.…”

Section: Plical Epitheliummentioning

confidence: 99%

“…The reticular-epithelial cells detected during embryonic development (Jolly, 1914;Ackerman and Knouff, 1959;Ackerman, 1962;Lupetti et al, 1990) or in adult life (Frazier, 1974;Glick, 1983;Houssaint et al, 1986;Eerola et al, 1987;Dolfi et al, 1990;Olah and Glick, 1992) have been described by ultrastructural studies (Frazier, 1974) and classified as pale, dark and intermediate cells. These cells had cytoplasmic processes which were often connected to the adjacent epithelial cells forming a supporting network for the lymphocytes.…”

mentioning

confidence: 99%

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Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

Mazzone¹,

Aita²,

Gabrielli³

et al. 2009

Eur J Histochem

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The Bursa of Fabricius of 15 day, 1-, 3-, and 6 month-old adult chickens (White Leghorn strain) were studied by histological and histochemical staining, histoenzymatic reactions (LDH, SDH, α-GPDH, NAD, NADPH, Ca ++ -dependent ATP-ase, pH 8.5) and by anti-thymostimulin immunoreaction. Positive reactions for mucopolysaccharides and enzymatic activities were located in the epithelia of the follicles, i.e. in follicleassociated-epithelium (FAE), inter-follicle-epithelium (IFE) and in different epithelial compartments of cortical and medullary zones. Positive reaction for thymostimulin-like (TSlike) substance was restricted to FAE cells and weakly to the basal lamina of IFE. In 6-month-old chickens, the FAE cells disappeared; the phenomenon of bursal regression was evident, although not all the follicles were involved. In the few still normal follicles, the good reactivity to the enzymes tested suggests that residual physiological activity is still present, even if reduced. , 1621) is a primary lymphoid organ peculiar to birds. The bursa is responsible for the maturation and differentiation of B-lymphocytes to produce humoral immunological responses. The other primary lymphoid organ, the thymus, instead, is responsible for the maturation and differentiation of T-lymphocytes, leading to cellular immunological responses (Dent and Good, 1965;Schaffner et al., 1974a;Le Douarin et al., 1984).The structure of the bursa has been described both during the ontogenetic period (Jolly, 1911a(Jolly, , 1914Cordier, 1969;Edwards et al., 1975;Le Douarin et al., 1975;Le Douarin et al., 1976;Le Douarin et al., 1984;Ritter and Lebacq, 1977) and during the posthatching period up to its involution (Jolly, 1911b(Jolly, ,1914Mc Connachie and Ruth, 1973;Glick, 1974Glick, , 1983Bellamy and Mohamed, 1982;Davenport and Allen, 1985).Since the discovery that the bursa was implicated in the differentiation of B-lymphocytes for humoral immunity (Chang et al., 1955;Glick et al., 1956;Papermaster and Good, 1962;Peterson and Good, 1965), attention was focused, on the one hand, on lymphoid cell populations (Ackermann and Knouff, 1959;Ackermann, 1962;Woods and Linna, 1965;Cooper et al., 1966; Toivanen et al., 1972 a,b;Toivanen et al., 1974;Back et al., 1973;Grossi et al., 1974;Grossi et al., 1976;Glick, 1974Glick, , 1983Glick, , 1995Glick et al., 1975;Eerola et al., 1982;Brand et al., 1983;Pink et al., 1985;Lassila, 1989;Nowak et al., 1990;Motyka and Reynolds, 1991;Petrini et al., 1991;Paramithiotis and Ratcliffe, 1993, 1994 a,b, 1996Reynaud and Weill, 1993;Masteller and Thompson, 1994;Masteller et al., 1995;Paramithiotis et al., 1995;Obranovich and Boyd, 1996;Funk and Thompson, 1996) and, on the other hand, on the epithelial stroma providing the bursal microenvironment within which B-cell maturation and differentiation occurs.

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Lymphocytopoiesis in the bursa of Fabricius

Cited by 128 publications

References 9 publications

Chick embryo pancreatic transplants reverse experimental diabetes of rats.

Chick embryo pancreatic transplants reverse experimental diabetes of rats.

Mesenchymal Origin of Bursal Lymphoid Cells in Japanese Quails

Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius

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