Lymphoepithelial carcinoma of the larynx

Coşkun, Berna Uslu; Çınar, Uğur; Sener, Belit Merve; Dadaş, Burhan

doi:10.1016/j.anl.2004.11.014

Cited by 27 publications

(25 citation statements)

References 8 publications

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“…On endoscopic examination, the tumour predominantly involves the laryngeal ventricle and spreads to the paraglottic and/or pre-epiglottic space [4,5,7] and can therefore have a misleading appearance with the tumour simply displacing the ventricular band or as ulceration of the epiglottic mucosa [4].…”

Section: Discussionmentioning

confidence: 99%

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Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx

Wassim

Belcadhi

Sriha

et al. 2015

European Annals of Otorhinolaryngology, Head and Neck Diseases

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Section: Discussionmentioning

confidence: 99%

“…In terms of treatment, the radiosensitivity of lymphoepithelial carcinoma allows conservative first-line treatment [1,4,7]. Surgery is indicated for locally advanced tumours [4].…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx

Wassim

Belcadhi

Sriha

et al. 2015

European Annals of Otorhinolaryngology, Head and Neck Diseases

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“…LEC accounts for approximately 5% of head and neck cancers [1] [2]. LEC was first described in the nasopharynx in 1921, and is also a tumor mostly located in the nasopharynx, where it represents 40% of all neoplasms [3]. Aside from the nasopharynx, this disease can also occur in other locations, including the oral cavity, salivary glands, parotid glands, etc.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and survival of lymphoepithelial carcinoma of the oral cavity and pharynx: a population-based study

Bai¹,

Zhao²,

S³

2019

Preprint

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Lymphoepithelial carcinoma (LEC) of the oral cavity and pharynx is uncommon, and the characteristics and survival remains unclear. The present study aims to describe the clinicopathological characteristics and determine the factors associated with survival of this uncommon cancer. A population-based study was carried out to investigate clinical characteristics and prognosis of LEC of the oral cavity and pharynx using the data from Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. The propensity-matched analysis was conducted for prognostic analysis, and a prognostic nomogram was also constructed. Totally, 1025 patients with LEC of the oral cavity and pharynx were identified, including 769 nasopharyngeal LEC patients and 256 non-nasopharyngeal LEC patients. The median OS of all LEC patients was 232.0m (95% CI 169.0-258.0). The 1-, 5-, 10-and 20-year survival rates were 92.9%, 72.9%, 59.3%, and 46.8%, respectively. Surgery could significantly prolong the survival time of LEC patients (P<0.01, mOS: 190m vs. 255m). Radiotherapy, as well as radiotherapy after surgery, could prolong the mOS (P<0.01 for both). The survival analysis demonstrated that old age (>60 years), lymph node (N3) and distant metastases were independent factors for poor survival, whereas radiotherapy and surgery were independent factors for favorable survival. No significant differences in survival time between nasopharyngeal LEC and non-nasopharyngeal LEC patients were observed. The prognostic nomogram was established base on five independent prognostic factors (C-index=0.70; 95% CI 0.66-0.74). In conclusion, LEC of the oral cavity and pharynx is a rare disease, and old age, lymph node and distant metastases, surgery and radiotherapy were significantly associated with prognosis. The prognostic nomogram could be used to make individual predictions of OS.

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“…Lymphoepithelial carcinoma (LEC) is a neoplasm mostly located in the nasopharynx where it represents 40% of all neoplasms [ 1 , 2 ]. It occurs worldwide but it has an endemic geographic distribution, particularly in Southeast Asia and Eskimos [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx

et al. 2017

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BackgroundLymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Therefore, it must be known by clinicians, pathologists and oncologists. In this case report, we discuss its etiopathogeny, its epidemiological, clinical, pathological and therapeutic aspects, and its outcome.Case presentationAn 81-year-old Morrocan man, smoker for 40 years, presented with a 1 year history of dysphonia, dyspnea and dysphagia. Laryngoscopy showed a mass occupying supraglottic, glottic and subglottic levels of the larynx. Cervico-thoracic computed tomography scan showed a laryngeal wall thickening with cervical lymphadenopathy. Laryngeal biopsy was performed. Microscopic analysis and immunohistochemistry confirmed the diagnosis of laryngeal lymphoepithelial carcinoma. Immunostaining for LMP1 was negative.ConclusionLaryngeal lymphoepithelial carcinoma is an extremely rare and an aggressive tumor. It is rarely associated with the EBV. It must be regarded as a distinct entity. Radiotherapy is advisable as the unique therapy for local tumor. A correct diagnosis and a close collaboration between the pathologist and clinicians is mandatory for an optimal treatment strategy.

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Lymphoepithelial carcinoma of the larynx

Cited by 27 publications

References 8 publications

Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx

Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx

Clinicopathological characteristics and survival of lymphoepithelial carcinoma of the oral cavity and pharynx: a population-based study

Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx

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