2017
DOI: 10.1186/s12894-017-0224-4
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Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

Abstract: BackgroundLymphoepithelioma-like carcinoma (LELC) is a rare high-grade carcinoma that resembles nasopharyngeal lymphoepithelioma and can occur throughout the body. First reported in 1991, bladder LELC has an incidence of about 1% of all bladder carcinomas. Due to its rare occurrence, prognoses and ideal treatment guidelines have not been clearly defined.MethodsA PubMed search was performed using two terms, “lymphoepithelioma-like carcinoma” and “bladder.” Review articles, articles in foreign languages, express… Show more

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Cited by 35 publications
(36 citation statements)
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“…Carcinomas with similar histological features arising outside the nasopharynx have been called lymphoepithelioma-like carcinomas and have been reported in other organs including the prostate, breast, uterine cervix, skin, lung, trachea, thymus, stomach and salivary glands [ 6 8 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Carcinomas with similar histological features arising outside the nasopharynx have been called lymphoepithelioma-like carcinomas and have been reported in other organs including the prostate, breast, uterine cervix, skin, lung, trachea, thymus, stomach and salivary glands [ 6 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…In this review the chief complaint was gross hematuria constantly present. The stage at diagnosis of those tumors was in 87% of cases T2–T3 stage [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…The lymphoepithelioma-like carcinoma (LELC) variant is another rare variant of bladder cancer which resembles lymphoepithelioma of the nasopharynx, a tumor defined by both a prominent lymphoid infiltrate and ubiquitous Epstein-Barr Virus (EBV) positivity [43]. However, unlike lymphoepithelioma of the nasopharynx, LELC are universally EBV negative and designated as lymphoepithelioma-like [44].…”
Section: Lymphoepithelioma-like Carcinomamentioning
confidence: 99%
“…In the urinary tract, they are typically, but uncommonly seen in the urinary bladder, although occasional cases have been reported in the renal pelvis, ureter and urethra [1,2].…”
Section: Introductionmentioning
confidence: 99%