Lymphoepithelioma-like breast carcinoma

Koufopoulos, Nektarios; Syrios, John; Papanikolaou, Asimina; Misitzis, Ioannis; Kapatou, K.; Dimas, Dionysis; Khaldi, Lubna

doi:10.5114/pjp.2018.75344

Cited by 13 publications

(5 citation statements)

References 40 publications

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“…It is specific to Asian populations and Epstein-BarrVirus (EBV) infection is generally acknowledged as the most important etiology [1, 2], even though not all LELC samples were positive in EBV detection [3]. Multiple tissues and organs, for example nasopharynx, stomach, skin, liver, could be involved by LELC [4–6]. Primary pulmonary LELC was first described in 1987 by Begin [7], and so far, there have been only 200 cases reported, accounting for less than 1% of all lung cancers [8].…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

Chen

Zhou

et al. 2019

Respir Res

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BackgroundPrimary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma. In the current study, clinical characteristics and outcome of primary pulmonary LELC were systematically compared with pulmonary squamous carcinoma.MethodsForty-two cases of primary pulmonary LELC and 134 squamous carcinomas were enrolled retrospectively. Characteristic and prognosis difference between the two groups was compared, and the independent prognostic factor for pulmonary LELC was identified as well.ResultsIn comparison to squamous carcinoma, pulmonary LELC was more common in women with a younger median age and less smokers. LELC seemed to be smaller in diameter on computed tomography (CT) scans than squamous carcinoma, with scarce spiculation and vascular convergence signs. Epstein-Bar virus-encoded RNA (EBER) by in-situ hybridization was detected in 33 LELC cases, among whom 27 ones were positive in serum EBV-DNA examination. LELC patients presented a much longer median progression-free survival (PFS) than squamous carcinoma. Positive serum EBV-DNA, distant lymph node invasion, advanced clinical stage and receiving radiotherapy were correlated with the shorter PFS in LELC patients. However, only positive serum EBV-DNA was the independent PFS predictor.ConclusionPulmonary LELC looks like distinct from squamous carcinoma. Middle-aged women and nonsmokers are comparatively predominated. CT features of pulmonary LELC are relatively less-malignant. Correspondently, the progression of pulmonary LELC is seemingly favorable than squamous carcinoma and the positive serum EBV-DNA appears to be the predictor of PFS.

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Section: Introductionmentioning

confidence: 99%

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

Chen

Zhou

et al. 2019

Respir Res

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“…Epstein-Barr virus is usually integrated in these nasopharyngeal tumors and this can be detected by in-situ hybridization. LELC could occur in other organs like lung (2), salivary gland (3), uterine cervix (4), stomach (5), breast (6), and skin (7), but its association with EBV infection is inconsistent. LELC in the thyroid has been only reported in very few case reports and is not included in WHO classi cation.…”

Section: Discussionmentioning

confidence: 99%

EBV negative lymphoepithelioma-like carcinoma of the thyroid gland: a rare entity and incidental presentation

Bendari

2023

Preprint

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Background: Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Primary LELC of the thyroid was previously named as intrathyroidal epithelial thymoma and carcinoma showing thymus-like differentiation (CASTLE) and the association with EBV has been inconsistently detected. This paper presents fine-needle aspiration cytology (FNAC) findings along with histologic features of LELC in a middle-aged female patient with incidental metastatic disease. Case presentation: A previously healthy 29-Year-old female who had an incidental palpable nodule in the right thyroid lobe on routine annual checkup. Thyroid U/S showed a 1.5 cm hypoechoic solid nodule with ill-defined margins. FNAC revealed papillary architecture and a few psammoma bodies on the background of dense lymphocytic infiltration. Thyroseq genomic sequencing revealed gene expression alterations with no gene mutation. The patient went for total thyroidectomy and right lymph node level 4 resection. The histologic slides of the nodule revealed solid arborizing bands of oval to spindled cells, associated with lymphoplasmacytic infiltrate and scattered psammoma bodies on the background of lymphocytic thyroiditis. There were no classic patterns of papillary or any aggressive features. Immunohistochemically, the tumor was positive for TTF1, PAX-8, and P40. In situ hybridization for EBV-encoded RNA was negative in the tumor cells. The patient has no tumor recurrence on 6-month follow up. Conclusion: Because LELC is very rare in the thyroid gland, careful clinical examination along with IHC stainings specific for thyroid follicular cells can help in proving its thyroid origin. Additionally, we hope to raise the awareness for this peculiar variant for accurate clinicopathological diagnosis.

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“…The lymphoid component in most cases of LELC has T lymphocytes (CD3+, CD8+) mixed with some B lymphocytes. In addition, medullary carcinoma has a syncytial growth pattern of more than 75%, complete circumscription, diffuse mononuclear stromal infiltrate, moderate to marked nuclear pleomorphism, and absence of microglandular features [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Breast: A Case Report of a Rare Type of Invasive Carcinoma

Salehiazar¹,

Huang²,

Aghighi³

et al. 2022

Cureus

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Lymphoepithelioma carcinoma (LELC) is an extremely rare type of mammary cancer. Based on the histology, it can be misdiagnosed with inflammatory lesions like mastitis and medullary carcinoma or other hematopoietic neoplasms like lymphoma in the breast. Since LELC has a good response to chemotherapy with a good prognosis, t is prognostically important to recognize LELC.We report a rare case of LELC in a 51-year-old pre-menopausal female with a left breast mass, diagnosed with invasive ductal carcinoma (IDC), LELC type, treated with mastectomy, followed by adjuvant chemotherapy and radiotherapy, with a disease-free interval of 10 months. Herein, we present the case with its clinical presentation, radiologic imaging, histopathological features, and immunohistochemistry (IHC) findings. The rarity of this type of breast tumor warrants studying the behavior of these uncommon tumors to avoid misdiagnosis and establish well-defined criteria for diagnosis.

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Lymphoepithelioma-like breast carcinoma

Cited by 13 publications

References 40 publications

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

EBV negative lymphoepithelioma-like carcinoma of the thyroid gland: a rare entity and incidental presentation

Lymphoepithelioma-Like Carcinoma of the Breast: A Case Report of a Rare Type of Invasive Carcinoma

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