Lymphoepithelioma-Like Carcinoma of the Skin: Case Report and Approach to Surgical Pathology Sign Out

Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only 1 previous case of a congenital lymphadenoma. An 8-year-old Asian girl presented with a congenital lesion on her forehead comprising 4 pink papules, the largest 5 mm in diameter. Microscopy revealed a well-circumscribed tumor within the dermis and subcutis comprising well-demarcated epithelial lobules of basaloid and clear cells with subtle peripheral palisading, growing in a collagenous stroma but lacking retraction artefact. A relatively dense accompanying predominantly lymphocytic inflammatory cell infiltrate including both T-cells (CD3+) and B-cells (CD20+) permeated the nodules and spilled into the stroma. CD68+ histiocytes and CD1a+ Langerhans cells were moderately numerous. This is the second case of congenital lymphadenoma which-in spite of its rarity in childhood-widens the diagnostic possibilities of cutaneous lymphoepithelial tumors in children.

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“…This is another tumor with epithelial nests permeated by lymphocytes. However, the epithelial cells show cytological atypia …”

Section: Discussionmentioning

confidence: 99%

Congenital cutaneous lymphadenoma

et al. 2017

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“…There have also been cases reported on the trunk, arm, and penis. 4 , 7 – 9 It often presents as a slowly growing flesh-colored or erythematous firm nodule, papule, or plaque. 1 The tumor normally affects elderly patients, with an almost equal sex ratio.…”

Section: Discussionmentioning

confidence: 99%

“…3 As was the case in this patient, some cases of LELCS have an overlying squamous cell carcinoma in situ (actinic keratosis). 4 Historically, LELCS has been speculated to be an adnexal neoplasm, 3 , 9 but in the new literature, LELCS is classified as a variant of squamous cell carcinoma. 4 …”

Section: Discussionmentioning

confidence: 99%

“… 2 LELCS was first described in 1988 by Swanson et al 3 and since approximately 70 cases in the English literature have been reported. 1 , 4 – 6 LELCS is a variant of squamous cell carcinoma, and histopathologically, it is related to lymphoepithelioma of the nasopharynx (undifferentiated nasopharyngeal carcinoma). 4 , 7 It is a malignant tumor with low metastatic risk.…”

mentioning

confidence: 99%

“… 1 , 4 – 6 LELCS is a variant of squamous cell carcinoma, and histopathologically, it is related to lymphoepithelioma of the nasopharynx (undifferentiated nasopharyngeal carcinoma). 4 , 7 It is a malignant tumor with low metastatic risk. Normally, it is treated with surgery, but more aggressive LELCS, including LELCS with perineural invasion, has also been treated with radiation and chemotherapy.…”

mentioning

confidence: 99%

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Lymphoepithelioma-like Carcinoma of the Skin

Lassen

Lock‐Andersen

2014

Plastic and Reconstructive Surgery Global Open

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Summary:Lymphoepithelioma-like carcinoma of the skin is a rare, low malignant cutaneous neoplasm. We report a case of an elderly woman with lymphoepithelioma-like carcinoma of the skin in the forehead. The tumor was mistaken first as actinic keratosis and later as metastatic squamous cell carcinoma. A histological reassessment showed lymphoepithelioma-like carcinoma of the skin with perineural invasion, which is rare and considered more aggressive. The patient therefore received adjuvant radiotherapy after the recommended wide excision. Lymphoepithelioma-like carcinoma of the skin is a variant of squamous cell carcinoma, and histologically, it resembles the more aggressive lymphoepithelioma of the nasopharynx. The later is Epstein-Barr positive, whereas lymphoepithelioma-like carcinoma normally is not. Lymphoepithelioma-like carcinoma is an important diagnosis to know and the disease is discussed.

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Tumours of Skin Appendages

Calonje

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter on cutaneous appendageal tumours covers the spectrum of lesions displaying eccrine, apocrine, sebaceous and follicular differentiation. It includes cysts, hamartomas and benign and malignant tumours. Traditionally, appendageal tumours have been classified according to rigid criteria separating lesions with eccrine, apocrine, sebaceous and follicular differentiation. This separation is clearly artificial and it is now acknowledged that lesions regarded as strictly eccrine may well have apocrine differentiation and lesions classified as purely follicular may exhibit apocrine differentiation reflecting the close embryological relationship between the pilosebaceous unit and the apocrine gland.

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Lymphoepithelioma-Like Carcinoma of the Skin: Case Report and Approach to Surgical Pathology Sign Out

Cited by 18 publications

References 11 publications

Congenital cutaneous lymphadenoma

Congenital cutaneous lymphadenoma

Lymphoepithelioma-like Carcinoma of the Skin

Tumours of Skin Appendages

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