Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus and high-risk human papilloma virus infection

Kohrenhagen, N.; Eck, M; Höller, Sylvia; Dietl, Johannes

doi:10.1007/s00404-007-0427-0

Cited by 22 publications

(39 citation statements)

References 11 publications

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“…Almost all nasopharyngeal carcinomas are associated with EBV genome integration [21] , as are LECs of the salivary gland [1] , lung [3,4] , thymus [5] , and stomach [7] . In contrast, EBV genome integration is not found in LECs of the oral cavity [22] , urinary bladder [8] , and uterine cervix [9,10] . In LECs of the biliary tract, 64% (9 of 14 cases) were EBVpositive.…”

Section: Discussionmentioning

confidence: 99%

“…dense lymphoplasmacytic infiltration is defined as a lymphoepithelioma-like carcinoma (LEC). Although the nasopharynx is a common site for LEC, it has been reported in other organs including salivary gland [1] , trachea [2] , lung [3,4] , thymus [5] , esophagus [6] , stomach [7] , urinary bladder [8] , uterine cervix [9,10] , and vagina [11] . Some LECs are associated with Epstein-Barr virus (EBV) infection [1,3,[5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

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Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Ishida

Mori²,

Shiomi³

et al. 2011

WJGO

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A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as a lymphoepithelioma-like carcinoma (LEC), and some of LEC is associated with Epstein-Barr virus (EBV). All of the 13 previously reported cases of LEC of the biliary system were intrahepatic in location. Herein, we describe the first case of LEC of the inferior common bile duct. A 68-year-old Japanese man, who had been previously treated for hepatocellular carcinoma using microwave coagulation therapy, was found to have tumors of the common bile duct and pancreas head. Histopathological study of the resected tumor showed solid or cohesive nests of large undifferentiated cells with irregular large vesicular nuclei and nucleoli. Around the tumor cell nests, dense lymphoplasmacytic infiltration was observed. Focal glandular differentiation (approximately 5%) was also present. These histopathological features corresponded morphologically to LEC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK 19 and CA19-9, but negative for CK 20 and Hep Par 1. In situ hybridization for Epstein Barr virus early small RNAs disclosed no nuclear signal in tumor cells. Therefore, a diagnosis of non-EBV-associated LEC of the inferior common bile duct was made. Although the prognosis of the biliary LEC is thought to be better than that of conventional cholangiocarcinoma, the differences in prognosis between EBV-positive and -negative cases have not yet been established. Therefore, additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Ishida

Mori²,

Shiomi³

et al. 2011

WJGO

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“…18 Epstein-Barr virus (EBV) has been shown to be strongly associated with LELCs of the nasopharynx, 19 stomach, 20 salivary glands, 4 lungs, 5,6 and thymus 21 in the form of integration of the viral genome in the tumor cell nuclei. However, this association has not been shown in LELCs of the urinary bladder, 11 uterine cervix, 22,23 or skin. 24 Regardless of EBV status, the morphologic features and prognosis are the same, except for the uncommon sites where the prognostic information is limited.…”

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confidence: 91%

“…26,27 There is controversial evidence of involvement of HPV in the uterine cervix; some authors report its presence, 28,29 whereas others do not. 23,30 The World Health Organization has recently recognized LELC, or inflammatory HCC (i-HCC), as a variant of HCC. 31 To date, 29 LELCs of the liver have been reported in the form of cholangiocarcinoma (n ¼ 20) and HCC (n ¼ 9), with only 1 lymphoepithelioma-like HCC (LEL-HCC) being positive for EBV 32 ( Table 1).…”

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confidence: 99%

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Patel

Liu

Vaccharajani

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The World Health Organization has recently recognized lymphoepithelioma-like carcinoma, or inflammatory hepatocellular carcinoma, as a variant of hepatocellular carcinoma.Objective.-To identify and characterize the inflammatory hepatocellular carcinomas in our institution from 1988 to the present.Design.-All cases of hepatocellular carcinoma in our institution from 1988 to the present were reviewed and reclassified as lymphoepithelioma-like carcinoma and were studied in comparison to appropriately matched controls.Results.-Among the 8 cases of lymphoepithelioma-like carcinoma identified, the male to female ratio was 1:3, the mean age was 68.5 years (range, 57-78 years), and all of the cases were seen in noncirrhotic livers. The average numbers of lymphocytes were significantly higher in the cases than in the controls. T cells were predominant, with a uniform distribution of CD4 and CD8 positive cells. Cholangiolar differentiation was seen by K19 positivity as focal in 1 case and diffuse in 2 cases. In situ hybridization for Epstein-Barr virus was negative in all of the cases. Diffuse overexpression of p16 (.75% of cells) was seen in 2 cases, both of which were negative for the presence of transcriptionally active human papilloma virus by in situ hybridization. In our series, 3 of 8 cases (37.5%) showed local recurrence, which was similar to the controls (6 of 18; 33%), P . .99. Although the rate of distant metastases was lower among the cases (12.5%) than the controls (22.2%), the difference was not statistically significant (P . .99).Conclusion.-We present the first series of 8 cases of lymphoepithelioma-like carcinoma of the liver occurring in patients without cirrhosis and with a female preponderance and the absence of Epstein-Barr virus. Although clinical outcomes were similar to those of controls in our small series, additional data may be required for confirmation.

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“…Similar tumours have been identified in other areas of body, including the stomach, salivary gland, lung, thymus, skin, breast and urinary bladder, where they are designated as lymphoepithelioma-like carcinomas (Skinner et al 2000). Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is an uncommon entity and constitutes approximately 0.7% of primary cervical malignancies (Kohrenhagen et al 2008). The WHO classification of epithelial tumours of uterine cervix categorises LELC as a histological subtype of squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 97%

Lymphoepithelioma-like carcinoma of the cervix

Saroha

Gupta

Singh

et al. 2010

Journal of Obstetrics and Gynaecology

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Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus and high-risk human papilloma virus infection

Abstract: This is the first study, that showed no relationship between LELC of the uterine cervix with EBV and high-risk HPV infections in a Caucasian woman.

Cited by 22 publications

References 11 publications

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Lymphoepithelioma-like carcinoma of the cervix

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