Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein–Barr virus, but presence of a multiple human papillomavirus infection

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

“…28,29 However, there are no studies to date evaluating the presence of HPV in LEL-HCCs. Our study is also the first to evaluate the expression of p16 protein and transcriptionally active HPV in such tumors, the results of which show diffuse p16 positivity in 1 of 8 cases and partial positivity in 2 of 8 cases, but also an absence of transcriptionally active HPV in the tumor cells.…”

“…26,27 There is controversial evidence of involvement of HPV in the uterine cervix; some authors report its presence, 28,29 whereas others do not. 23,30 The World Health Organization has recently recognized LELC, or inflammatory HCC (i-HCC), as a variant of HCC.…”

Lymphoepitelioma-like hepatocellular carcinoma: A case report and a review of the literature

“…Subsequently, histologically similar carcinomas have been described in other organs, such as salivary glands [2] , lung [3] , stomach [4] , colon [5] , thymus [6] , uterus [7] , bladder [8,9] and urinary tract [10] . Lymphoid stroma-rich carcinomas in these locations have been termed Lymphoepithelioma-like carcinoma (LELC).…”

Lymphoepithelioma-like carcinoma of the cervix

“…Similarly, Martorell et al (2002) and Kohrenhagen et al (2008) did not find any relationship between roles of EBV, HPV or simian virus 40 in the pathogenesis of LELC of the uterine cervix in Western women. However, Bais et al (2005) suggested that EBV is associated with cervical LELC in Asian women whereas human papilloma virus (HPV) might play an aetiology role in the Western women. Thus, further investigations with a larger number of patients are required to conclusively establish the role of EBV and HPV in the pathogenesis of LELC cervix.…”