Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

Bösmüller, Hans; Haitchi-Petnehazy, Sophie; Gruber, C.; Roithmeier, F; Stummvoll, W.; Webersinke, Gerald

doi:10.1186/1746-1596-6-4

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…PLEC is analogus and exhibits identical histopathological characteristics as non-keratinizing, undifferentiated nasopharyngeal carcinomas (NPC) 3 . However PLEC arises in organs other than nasopharynx, such as larynx 4 , tonsils 5 , lung 6 , thymus 7 , stomach and duodenum 8 , breast 9 , renal pelvis and urinary bladder 10 , uterine cervix 11 , endometrium 12 , ovary 13 , vulva and vagina 14 .…”

Section: Primarymentioning

confidence: 99%

Primary lymphoepithelial-like carcinoma of the parotid gland-case presentation

Poulopoulos¹,

Parcharidis²,

Nikolaidou³

et al. 2018

Balkan J Dent Med

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SummaryBackground/Aim: Primary Lymphoepithelial carcinoma (PLEC) is a rare subtype of salivary gland cancers, which comprises only 0.4% of salivary malignant neoplasms and only a few cases have been presented previously. Case report: A patient with PLEC of the parotid gland, its management and the available literature are presented. A 53-year-old woman with initial lesion of a lump in the region of the right parotid received treatment with antibiotics which did not lead to improvement. MRI was performed that recorded the presence of a tumor in the right parotid gland and the patient subsequently underwent excision biopsy. The histopathological evaluation together with additional immunohistochemical positive staining of EMA+, EGFR+, p63+, CK 5/6+, AE1/AE3+ established the diagnosis of PLEC. A PET-CT scanning has shown nor primary mucosal source neither skin lesion to account for any possible metastatic disease, consequently a course of adjuvant post-operative radiotherapy to the region of the right parotid gland was performed. Conclusions: In the differential diagnosis of a parotid gland lump should be included the possibility of a rare salivary gland neoplasm such as PLEC. Surgical excision and radiotherapy have been proposed for the treatment of early and advanced neoplasm stages. Ages of the patient, stage of the neoplasm as well as type of therapy are significant and individual variables for the prediction of the prognosis.

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Section: Primarymentioning

confidence: 99%

Primary lymphoepithelial-like carcinoma of the parotid gland-case presentation

Poulopoulos¹,

Parcharidis²,

Nikolaidou³

et al. 2018

Balkan J Dent Med

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“…In the genital tract, this pathological entity is very rare, mainly described in the cervix, where it could be associated with Human Papillomavirus (HPV) infection [4–7]. Exceptionally, these tumors have been also encountered in the rest of genital tract including vulva, vagina, ovary, and endometrium [8–11]. In the endometrium, to the best of our knowledge, only 5 cases of lymphoepithelioma-like carcinoma have been reported [12–16].…”

Section: Introductionmentioning

confidence: 99%

PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium

Bienfait

D’Haene

Catteau

et al. 2018

Case Reports in Pathology

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Lymphoepithelioma-like carcinoma of the endometrium is a very rare variant of endometrial carcinoma characterized by syncytial nests of pleomorphic epithelial cells and heavy infiltration of the stroma by lymphocytes (in particular CD8 cytotoxic T-lymphocytes) and plasma cells. Until now, only five cases have been characterized in this location. This report describes the clinicopathological and the molecular features of this unusual tumor. In particular, using the next generation sequencing (NGS) technique, we have demonstrated that this tumor could be associated with PIK3CA and p53 gene mutations. These data have not been reported to date and suggest that lymphoepithelioma-like carcinoma of the endometrium shares common molecular features with high grade endometrioid and serous-like endometrial carcinoma which are associated with poor outcome. Nevertheless, in endometrial lymphoepithelioma-like carcinoma, the alterations on cell cycle, apoptosis, and/or senescence secondary to p53 mutations could potentially be counterbalanced by the antitumoral response induced by CD8 cytotoxic T-lymphocytes numerous in these tumors.

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“…The association with EBV infection in LELC is different in various locations and in different geographic regions. EBV positivity has been described in tumours of lung, stomach, thymus, and salivary gland [2,3,4,5], but it has not been demonstrated in cases of LELC occurring in the urinary bladder, renal pelvis, breast, and in the female genital tract [6,7,8,9,10]. It has been suggested that EBV positivity is related to a direct organ exposure to the external environment, and EBV negativity is more common in internal organs [11].…”

Section: Introductionmentioning

confidence: 99%

“…However, in LELC of uterine cervix the association with EBV has been observed only in a few Asian patients, but not in western countries [12,13]. In the female genital tract LELC mostly occurs in the cervix, where it is regarded as a variant of squamous cell carcinoma, but cases involving the vulva, vagina, endometrium, and ovary have also been reported [9,10,12,13,14,15,16,17,18,19]. To the best of our knowledge, only six cases of LELC arising in the endometrium have been reported to date; however, none of these was accompanied by a molecular genetic analysis, with the exception of molecular testing for microsatellite instability (MSI) in one of the cases [14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma of the endometrium: Case report of a rare tumour with comprehensive immunohistochemical and molecular analysis

Němejcová¹,

Hájková²,

Tichá³

et al. 2018

pjp

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We are reporting a case of endometrial lymphoepithelioma-like carcinoma (LELC) in a 63-year-old female. Microscopically, the tumor consisted of groups of tumor cells surrounded by dense lymphoplasmacytic infiltrate. Immunohistochemically, the tumour cells were positive for cytokeratins AE1/AE3, EMA, PAX8, p16, and estrogen receptors. Protein p53 showed an aberrant type of expression. Molecular genetic analysis revealed mutations in the TP53 and PIKP53CA genes. Based on our results, we believe that the tumor represents an unusual morphological variant of endometrial serous carcinoma.To the best of our knowledge, only six cases of LELC arising in endometrium have been reported in literature to date.

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Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

Cited by 8 publications

References 23 publications

Primary lymphoepithelial-like carcinoma of the parotid gland-case presentation

Primary lymphoepithelial-like carcinoma of the parotid gland-case presentation

PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium

Lymphoepithelioma-like carcinoma of the endometrium: Case report of a rare tumour with comprehensive immunohistochemical and molecular analysis

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