Lymphoepithelioma-like cholangiocarcinoma with Epstein–Barr virus infection treated by radiofrequency ablation

Nogami, Atsushi; Saito, Satoru; Hasegawa, Hiromasa; Yoneda, Masato; Harada, Kenichi; Fujikawa, Hirotoshi

doi:10.1007/s12328-020-01303-4

Cited by 8 publications

(15 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 43.4% rate of HBV infection observed in our case summary is higher than that reported by Ding et al in 2019 (26.9%, n = 26 cases), 8 Zhang et al in 2020 (39%, n = 34 cases), 7 and Nogami et al in 2021 (39.3%, n = 61 cases). 10 These findings suggest that the HBV infection rate may be on the rise and indicate that HBV may play a role in the tumorigenesis of LELCC, similar to EBV. In our case summary, only 12.1% of patients had liver cirrhosis, similar to the rate reported by Zhang et al (14.7%) 7 and Nogami et al (11.5%).…”

Section: Discussionmentioning

confidence: 83%

“…In our case summary, only 12.1% of patients had liver cirrhosis, similar to the rate reported by Zhang et al (14.7%) 7 and Nogami et al (11.5%). 10 The high incidence of HBV and EBV and low incidence of liver cirrhosis indicate that virus infection may play a larger role than liver cirrhosis in the pathogenesis of LELCC, which would be a major difference from hepatocellular carcinoma. Further studies are needed to test this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…As we know, this is not the only case where the diagnosis is unclear in the absence of pathology. 10 Studies of imaging features of LELCC and other rare diseases are needed to further understanding and more accurate diagnosis of these diseases. [15][16][17][18] Furthermore, this case suggests that MWA may be an effective therapeutic method for LELCC patients.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Lymphoepithelioma‑Like Cholangiocarcinoma with Hepatitis C Virus Infection Treated by Microwave Ablation: A Literature Review and Case Report

Li¹,

Ji²,

Zhang³

et al. 2022

CMAR

View full text Add to dashboard Cite

Background: Lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare type of intrahepatic tumor that is poorly understood. It is not associated with specific physical findings and is usually diagnosed incidentally, resulting in tumors that are often large-sized at diagnosis. At present, the main treatment approach is surgical resection. Case Presentation: Here, we report the case of a patient with LELCC treated with microwave ablation (MWA). Our patient was a Chinese man with chronic hepatitis C and a 51 mm-diameter intrahepatic tumor. Despite blood testing, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging, and abdominal ultrasound, the tumor was not well diagnosed. However, the histopathological findings of ultrasound-guided percutaneous tumor biopsy led to a diagnosis of LELCC. The patient was treated with MWA, and no new lesions had occurred at 9 months after treatment. Conclusion: To our knowledge, this is the first patient with LELCC treated using MWA. Our experience suggests that MWA is an effective new therapeutic method for this disease.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lymphoepithelioma‑Like Cholangiocarcinoma with Hepatitis C Virus Infection Treated by Microwave Ablation: A Literature Review and Case Report

Li¹,

Ji²,

Zhang³

et al. 2022

CMAR

View full text Add to dashboard Cite

show abstract

“…LEL-CC was first reported in 1996 by Hsu et al . 10 To our knowledge, 101 cases (including the present case) have been reported in the English literature ( Supplemental Table 1 ) 9 – 37 . Of these 101 cases, 74% were published after 2015; the number of reports has increased in recent years.…”

Section: Discussionmentioning

confidence: 85%

“…There is no specific symptom that suggests the presence of LEL-CC; it is often detected incidentally during imaging studies of asymptomatic patients. 36 Recently, several studies have been published regarding the imaging findings of LEL-CC. Yang et al .…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like cholangiocarcinoma not associated with Epstein–Barr virus or hepatitis virus: case report and literature review of 100 reported cases

et al. 2022

View full text Add to dashboard Cite

Lymphoepithelioma-like cholangiocarcinoma (LEL-CC) is a type of lymphoepithelioma-like carcinoma (LELC) and a rare variant of primary liver tumor. Although it is uncommon and only 100 cases have been reported thus far, the number of reports has increased in recent years. LEL-CC reportedly occurs more frequently in Asian women; Epstein–Barr virus (EBV) and hepatitis viruses are both strongly associated with tumor development. Here, we describe a 76-year-old woman who exhibited LEL-CC not associated with EBV or hepatitis virus. She was referred to our department with a 3.0-cm × 2.8-cm tumor in the left lobe of the liver. Based on computed tomography and magnetic resonance imaging findings, the tumor was preoperatively diagnosed as hepatocellular carcinoma. Thus, we performed extended left hepatectomy with caudal lobectomy. Histopathological examinations revealed columnar tumor cells with atypical nuclei that proliferated in a cord-like or glandular tubular pattern with dense lymphocytic infiltration. Immunohistochemical analysis showed negative HepPar-1 and arginase findings, indicating non-hepatocyte origin; however, the biliary-type cytokeratins CK7 and CK19 were detected. Based on these findings, the tumor was identified as LEL-CC. EBV-encoded RNA in situ hybridization findings were negative; the patient’s clinical characteristics were not suggestive of hepatitis virus infection. In conclusion, we suggest that clinicians consider LEL-CC as a differential diagnosis for liver tumors in Asian women, including patients without EBV or hepatitis virus.

show abstract

Rare histotypes of epithelial biliary tract tumors: A literature review

Sapuppo

Brunetti

Tessitore

et al. 2023

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Lymphoepithelioma-like cholangiocarcinoma with Epstein–Barr virus infection treated by radiofrequency ablation

Cited by 8 publications

References 26 publications

Lymphoepithelioma‑Like Cholangiocarcinoma with Hepatitis C Virus Infection Treated by Microwave Ablation: A Literature Review and Case Report

Lymphoepithelioma‑Like Cholangiocarcinoma with Hepatitis C Virus Infection Treated by Microwave Ablation: A Literature Review and Case Report

Lymphoepithelioma-like cholangiocarcinoma not associated with Epstein–Barr virus or hepatitis virus: case report and literature review of 100 reported cases

Rare histotypes of epithelial biliary tract tumors: A literature review

Contact Info

Product

Resources

About