Lymphoepithelioma-like esophageal carcinoma: Report of a case

Yamada, Tetsuji; Tatsuzawa, Yasuhiko; Yagi, Shingo; Fujioka, Shigeichi; Kitagawa, Susumu; Nakagawa, Masaaki; Minato, Hiroshi; Kuroda, Hiroshi; Matsunou, Hisao

doi:10.1007/bf02482349

Cited by 18 publications

(9 citation statements)

References 5 publications

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“…LELCS histologically resembles the lymphoepitheliomatous malignancies that have been described to occur in the nasopharynx, 4 palatine tonsils, 5 salivary glands, 6 lung, 7–9 thymus, 10 gastrointestinal tract, 11,12 kidney, 13,14 ureter, 15,16 urinary bladder, 17 breast, 18 and uterine cervix 19 . Microscopic examination reveals a multifocal distribution of tumor involving the mid to reticular dermis and occasionally the subcutis and skeletal muscle 1,20 .…”

Section: Discussionmentioning

confidence: 92%

Lymphoepithelioma-Like Carcinoma of the Skin: A Report of Two Cases Treated With Complete Microscopic Margin Control and Review of Literature

Glaich¹,

Behroozan²,

Cohen³

et al. 2006

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 92%

Lymphoepithelioma-Like Carcinoma of the Skin: A Report of Two Cases Treated With Complete Microscopic Margin Control and Review of Literature

Glaich¹,

Behroozan²,

Cohen³

et al. 2006

Dermatologic Surgery

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“…Lymphoid stroma-rich carcinomas arising in other organs are called LELCs and have been reported in a variety of anatomic sites including the skin [17-20], lacrimal and salivary glands [21,22], thyroid gland [23], thymus [24], breast [25], lung [26], esophagus [27], stomach [28], colon [29], renal pelvis [30-33], ureter [32], kidney [31], bladder [34], prostate [31], uterine cervix [35], vulva [36,37], and vagina [38]. LELC in the liver has also been reported, but most of these cases have instead been referred to as LEL-CCCs [1-8].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

et al. 2013

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We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.

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“…The sizes were more than 1.3 cm in a diameter. Only one case 19 looked like a benign submucosal tumor with an unclear boundary and without a depression or ulcer, like our case. We should be aware that esophageal LELC usually appear as a submucosal tumor and may be confused with a benign tumor.…”

Section: Discussionmentioning

confidence: 53%

“…Lymphoepithelioma‐like carcinoma has been described in various organs including the salivary gland, thymus, thyroid, breast, lung, stomach, urinary bladder, uterine cervix and skin 3–11 . According to Medline's database ‘PubMed’, 16 LELC cases arising in the esophagus have been documented in the English literature 13–23 . This includes the cases described as poorly differentiated carcinoma with prominent lymphocytic infiltration.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma‐like carcinoma of the esophagus: Report of a case with non‐progressive behavior

Nakasono

Hirokawa

Suzuki³

et al. 2007

J of Gastro and Hepatol

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Lymphoepithelioma-like carcinoma (LELC) of the esophagus is extremely rare and the prognosis has been described to be favorable. Herein, the case is reported of esophageal LELC showing non-progressive course for 1 year. The patient was a 70-year-old Japanese man with a submucosal tumor in the lower esophagus. The tumor was endoscopically regarded as a benign leiomyoma. One year after the first endoscopic examination, the size of the lesion remained unchanged despite no treatment. Histologically, the tumor showed undifferentiated carcinoma associated with dense lymphocytic and plasma cell infiltration. Lymphoid follicles surrounded the tumor cell nests. Immunohistochemically, Ki-67 labeling index of the tumor cells were 76.0%, and there were few single-strand DNA-positive apoptotic cells. In situ hybridization using a digoxigen-labeled Epstein-Barr virus (EBV)-encoded small RNA (EBER)-1 riboprobe failed to detect the presence of EBV infection. Physicians should be aware that esophageal LELC endoscopically mimics benign submucosal tumor. This case may demonstrate that esophageal LELC is a slow-growing tumor and it is related to immune reaction.

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Lymphoepithelioma-like esophageal carcinoma: Report of a case

Cited by 18 publications

References 5 publications

Lymphoepithelioma-Like Carcinoma of the Skin: A Report of Two Cases Treated With Complete Microscopic Margin Control and Review of Literature

Lymphoepithelioma-Like Carcinoma of the Skin: A Report of Two Cases Treated With Complete Microscopic Margin Control and Review of Literature

Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

Lymphoepithelioma‐like carcinoma of the esophagus: Report of a case with non‐progressive behavior

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