Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome—a case report

Kiliś‐Pstrusińska, Katarzyna; Medyńska, Anna; Zwołińska, Danuta; Dobaczewski, Grzegorz

doi:10.1007/s00467-007-0666-0

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…The survival time of these patients barely exceeded 1 year [5,6]. We summarize the clinical data and prognosis of the reported cases [2,3,[7][8][9][10][11][12][13][14][15][16][17][18][19] and ours ( Table 1). We can nd that the patients are dominated by adolescents and the elderly, and most patients with tumor metastasis have poor prognosis.…”

Section: Discussionmentioning

confidence: 94%

Clinicopathological Features and Treatment of Thymic Lymphoepithelioma-Like Carcinoma: Two Case Reports and Literature Review

Guan

Zhang²,

Han³

et al. 2020

Preprint

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Background: Lymphoepithelioma-like carcinoma (LELC) is rare in the thymus, which is easy to be misdiagnosed. To improve its clinicopathological knowledge, we describe two cases of thymic LELC, and investigate their clinicopathological features (microscopical and immunohistochemical features), treatment and follow-up data with a review of previously published cases. Case presentation: Two patients in the First Affiliated Hospital of China Medical University underwent complete surgical resection for thymic LELC. In both, they were treated with chemotherapy or radiotherapy after operation. Histologically, tumor cells were arranged in nest-like patterns or stripe-shaped infiltration in collagen fibrous interstitial tissue containing lymphocytes. And the tumor cells were diffusely positive for broad spectrum pan-cytokeratin (CK), CK19, CD5, CD117, epithelial membrane antigen (EMA) and p63, focally positive for CD20, and negative for TdT. Recent clinical reexamine showed that the two patients were alive with no signs of recurrence.Conclusion: We report two cases of thymic LELC with a review of previously published cases to summarize the knowledge of their clinicopathological characteristics, which is necessary for the accurate diagnosis and clinical treatment.

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Section: Discussionmentioning

confidence: 94%

Clinicopathological Features and Treatment of Thymic Lymphoepithelioma-Like Carcinoma: Two Case Reports and Literature Review

Guan

Zhang²,

Han³

et al. 2020

Preprint

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“…Squamous cell carcinoma and LELC are relatively common subtypes of adult thymic carcinoma. However, to the best of our knowledge, only 13 cases of LELC have been reported in children ( Table I ) ( 5 – 15 ). EBV is hypothesized to be associated with LELC and LMP-1 is considered to be a predominant EBV oncoprotein ( 7 , 24 – 26 ).…”

Section: Discussionmentioning

confidence: 99%

“…Thymic carcinoma was previously defined as a type C thymoma by the World Health Organization ( 3 ); however, it was reclassified as a distinct entity in 2004, as it exhibits a higher cytological atypia and poorer clinical outcome compared with thymoma ( 4 ). Thymic lymphoepithelioma-like carcinoma (LELC) is a histological subtype of aggressive thymic carcinoma, which is frequently associated with the Epstein-Barr virus (EBV) and, although it is a relatively common subtype of thymic carcinoma in adults, only 13 cases have been reported in children ( 5 – 15 ). Optimal chemotherapeutic regimens have not yet been determined for the treatment of thymic carcinoma ( 16 ), thus, previous case studies were conducted based on the original regimens for advanced thymoma.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome of thymic lymphoepithelioma-like carcinoma: Case report of a 14-year-old male

et al. 2014

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Thymic carcinoma is a rare type of cancer, which arises from the thymic epithelium and accounts for ~1–4% of anterior mediastinal tumors in the USA. It rarely occurs in children, and is rarer among adults. Thymic lymphoepithelioma-like carcinoma (LELC) is an uncommon subtype of thymic carcinoma in children, however, it is one of the common histological subtypes of thymic carcinoma in adults. In the present study, a 14-year-old male patient presented to the Tokyo Metropolitan Cancer and Infectious diseases Center, Komagome Hospital (Tokoyo, Japan) with chest pain due to a large anterior mediastinal mass. The patient was histologically diagnosed with thymic LELC via a needle biopsy specimen, which was obtained from the primary site and indicated the Epstein-Barr virus infection, whose markers are also associated with oncogenesis. Immunohistochemical analysis demonstrated positive staining for keratin (AE1/AE3), epithelial membrane antigen, and latent membrane protein-1 and negative staining for cluster of differentiation 5. Thus, the patient was diagnosed with metastatic thymic LELC. First-line chemotherapy comprising of a cisplatin- and adriamycin-based chemotherapy regimen achieved a partial response, however, the patient succumbed within 10 months of the initial diagnosis due to rapid disease progression and refractory to subsequent cycles of chemotherapy. Thus, the current study, as well as previously reported cases, demonstrates that pediatric patients with thymic LELC continue to have a poor prognosis.

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“…According to Bochniewska et al [39], currently children with urolithiasis account for 10% of all children hospitalized in Poland, in comparison to 2% in previous studies. In studies conducted by Kiliś-Pstrusińska et al [40], it was shown that children > 4 years of age accounted for 16% of all patients treated for urolithiasis in 1995-1999 at the Pediatric Nephrology Clinic in Wrocław. According to Gołąbek et al [41], infants and children < 2 years of age accounted for 49% of all patients with uric acid stones.…”

Section: Epidemiology Of Urolithiasismentioning

confidence: 99%

The role of selected environmental factors and the type of work performed on the development of urolithiasis – a review paper

Wróbel¹,

Kuder²

2019

Int J Occup Med Environ Health

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Urolithiasis is a disease of the genitourinary system, which is defined as the presence of urinary stones at any place in the urinary tract, resulting from the precipitation reaction of chemical compounds. The aim of this study is to demonstrate the important role of selected environmental factors (climate, ambient temperature) and the type of profession performed in the development of urolithiasis. In this field, the literature including original and review papers related to the epidemiology, pathogenesis and risk factors of urolithiasis was analyzed. The study used electronic databases such as Medline, Web of Science and Google Scholar. The prevalence of urolithiasis has increased in recent decades in both developed and developing countries. It is believed that this growing trend is associated with lifestyle changes such as the lack of physical activity, poor eating habits and global warming. Many factors are responsible for the formation of urinary stones. In literature, there is a division into individual and environmental factors. Today, external factors in the form of climate changes (global warming), geographical conditions and seasonal fluctuations, and the type of profession performed are becoming more and more important in the context of the occurrence of urinary stones. Currently, the presence of urolithiasis is becoming a significant problem all over the world and searching for causes is not easy, but particular attention should be paid to certain predispositions resulting from environmental factors, such as ambient temperature and the type of work performed.

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Lymphoepithelioma-like thymic carcinoma in a 16-year-old boy with nephrotic syndrome—a case report

Abstract: Nephrotic syndrome can occur as a consequence of, among others, malignancy. In this report we describe a 16-year-old boy with secondary nephrotic syndrome associated with lymphoepithelioma-like thymic carcinoma, an extremely rare subtype ofthymic carcinoma with poor prognosis.

Cited by 16 publications

References 11 publications

Clinicopathological Features and Treatment of Thymic Lymphoepithelioma-Like Carcinoma: Two Case Reports and Literature Review

Clinicopathological Features and Treatment of Thymic Lymphoepithelioma-Like Carcinoma: Two Case Reports and Literature Review

Clinical outcome of thymic lymphoepithelioma-like carcinoma: Case report of a 14-year-old male

The role of selected environmental factors and the type of work performed on the development of urolithiasis – a review paper

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