Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature

Sonoda, Hirofumi; Kawai, Kazushige; Yamaguchi, Hironori; Murono, Koji; Kaneko, Manabu; Nishikawa, Takeshi; Otani, Kensuke; Sasaki, Kazuhito; Yasuda, Koji; Tanaka, Toshiaki; Kiyomatsu, Tomomichi; Hata, Keisuke; Nozawa, Hiroaki; Ishihara, Soichiro; Aikou, Susumu; Yamashita, Hiroharu; Ushiku, Tetsuo; Seto, Yasuyuki; Fukayama, Masashi; Watanabe, Toshiaki

doi:10.1016/j.clinre.2017.04.002

Cited by 14 publications

(24 citation statements)

References 24 publications

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“…Another unique feature of our case is the location of SRC metastasis. A literature review done by Sonoda et al showed 11 cases of primary gastric SRC with metastasis to the large intestine, out of which six cases had metastasis to the sigmoid colon and only one case of metastasis to the rectum [9]. Our patient had an uncommon metastasis to the rectosigmoid junction [18][19].…”

Section: Discussionmentioning

confidence: 56%

“…SRC occurs primarily in the stomach with common sites of metastasis being the lymph nodes, peritoneum, and intestines. Most of the time, when there is a large intestinal metastasis, the primary malignancy is usually the stomach [9]. Our case has been one among such where the patient was found to have ascites and a rectosigmoid stricture, which led to further investigation and tracing of the primary malignant lesion to the stomach.…”

Section: Discussionmentioning

confidence: 78%

“…The literature review revealed various macroscopic presentations of the metastatic intestinal lesions. They included mostly polyps [ 10 - 13 ], ulcerations [ 14 - 15 ], and depressed lesions [ 9 , 16 - 17 ]. However, literature on metastatic lesions of a gastric SRC presenting as a colonic stricture is rare.…”

Section: Discussionmentioning

confidence: 99%

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Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case

Mehershahi¹,

Mantri²,

Sun³

et al. 2020

Cureus

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We present the case of a 55-year-old man who was admitted with new abdominal ascites and change in stool caliber. The colonoscopy examination revealed a severe stricture with inflamed friable mucosa measuring 8 cm in length in the rectosigmoid colon. Histologically, poorly differentiated adenocarcinoma with signet ring cells was seen. The patient underwent esophagogastroduodenoscopy (EGD), which was suggestive of linitis plastica of the stomach. On microscopic examination, biopsy reported poorly differentiated adenocarcinoma with occasional signet ring cells as the primary source.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 78%

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Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case

Mehershahi¹,

Mantri²,

Sun³

et al. 2020

Cureus

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“…Lymphatic and hematogenous dissemination could be the possible route for distant skin metastasis, while direct invasion, hematogenous, lymphatic, and peritoneal seeding are traditionally considered as the routes for colonic metastasis. [ 9 ] Besides, some studies have indicated that gastric cancer could metastasize to privileged sites through the fifth route, in which gastric cancer cells could drop into the “bare area” of the mesogastrium and subsequently scatter in the abdominal cavity during surgical resection, ultimately leading to locoregional recurrence. [ 10 ] Since skin metastasis occurred before colonic metastasis, the colonic metastasis might derive from the skin lesion, but recent studies have shown that circulating tumor cells existing in peripheral blood is also link to recurrence and metastasis of gastric carcinoma, [ 11 ] so the exact relationship between the skin metastasis and the colonic metastasis could not be determined due to limitation of detection technology, insufficient cognition of cancer and heterogeneity in the process of tumor progression.…”

Section: Discussionmentioning

confidence: 99%

“…In this case, the cutaneous and colonic metastasis that originated from the gastric cancer were poorly differentiated adenocarcinoma with signet-ring cell carcinoma, which is in agreement with the observations in the previous studies. [ 9 ] The advanced histological grade and positive expression of ki67 status in the primary gastric cancer and gastric cancer metastasis-derived skin cancer and intestinal cancer implicated that the cancer was highly malignant, and would result in poor clinical outcome. [ 14 , 15 ] HER-2 overexpression is closely associated with cell proliferation and differentiation and tumor invasion, and is an important predictor for the prognosis of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Solitary metastasis to the skin and colon from gastric cancer after curative gastrectomy and chemotherapy

Yang¹,

Liu

Guo

et al. 2020

Medicine

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Rationale: Gastric cancer usually spread via blood circulation to liver, lung, bone, and kidney after recurrence, but it is extremely rare in clinical practice that gastric carcinoma metastasizes to the skin and colon without metastasis to common sites like liver or lung. Patient concerns: A 57-year-old man was admitted to the hospital with altered bowel habit and hematochezia for 2 weeks. Diagnoses: The patient was diagnosed with advanced gastric cancer at stage IIIA (pT3N2M0) two and a half years ago. Cutaneous metastasis from gastric cancer was confirmed by cutaneous biopsy 2 years following curative gastrectomy. Unfortunately, colonic metastasis from gastric cancer was found by PET-CT 6 months after the diagnosis of cutaneous metastasis. Interventions: The patient was given chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for the skin metastasis. Right hemicolectomy was performed when the malignant tumor of the colon was found, in order to relieve the symptom, and improve the quality of life. Outcomes: The patient was treated with chemoradiotherapy in a local hospital, the peritoneal carcinomatosis occurred 5 months after the second operation, and died 9 months after the diagnosis of colonic metastasis. Lessons: Our case represents a rare condition that solitary cutaneous and colonic metastasis from gastric cancer can occur after surgical resection and systemic chemotherapy. Its unique clinicopathological features can extend our insights on gastric cancer, and it may provide clinicians with some positive clinical experience for identifying and treating this disease.

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Development of a Signature Based on Eight Metastatic-Related Genes for Prognosis of GC Patients

et al. 2023

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Gastric cancer (GC) has been a common tumor type with high mortality. Distal metastasis is one of the main causes of death in GC patients, which is also related to poor prognosis. The mRNA profiles and clinical information of GC patients were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. Univariate Cox and LASSO Cox analyses were used to screen the optimal metastasis-related genes (MRGs) to establish a prognostic Risk Score model for GC patients. The nomogram was used to visualize the Risk Score and predict the 1-, 3-, 5-year survival rate. The immune cell infiltration was analyzed by CIBERSORT and the ratio of immune–stromal component was calculated by the ESTIMATE algorithm. A total of 142 differentially expressed genes were identified between metastatic and non-metastatic GC samples. The optimal 8 genes, comprising GAMT (guanidinoacetate N-methyltransferase), ABCB5 (ATP-binding cassette subfamily B member 5), ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3), GDF3 (growth differentiation factor 3), VSTM2L (V-set and transmembrane domain-containing 2 like), CIDEA (cell death inducing DFFA like effector a), NPTX1 (neuronal pentraxin-1), and UMOD (uromodulin), were further screened to establish a prognostic Risk Score, which proved to be an independent prognostic factor. Patients in high-risk group had a poor prognosis. There were significant differences in the proportion of 11 tumor-infiltrating immune cells between high-risk and low-risk subgroups. In addition, the StromalScore, ImmuneScore, and ESTIMATEScore in high-risk group were higher than those in low-risk group, indicating that the tumor microenvironment of the high-risk group was more complex. A Risk Score model based on eight metastasis-related genes could clearly distinguish the prognosis of GC patients. The poor prognosis of patients with high-Risk Score might be associated with the complex tumor microenvironments.

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Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature

Cited by 14 publications

References 24 publications

Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case

Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case

Solitary metastasis to the skin and colon from gastric cancer after curative gastrectomy and chemotherapy

Development of a Signature Based on Eight Metastatic-Related Genes for Prognosis of GC Patients

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