Lymphogranuloma venereum in Quebec: Re-emergence among men who have sex with men

Boutin, C; Venne, Sylvie; Fiset, Marc; Fortin, Claude; Murphy, D.P.; Severini, Alberto; Martineau, Christine; Longtin, Jean; Labbé, Annie‐Claude

doi:10.14745/ccdr.v44i02a04

Cited by 10 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The group of patients exhibited several similarities with those affected in Europe and Western Countries, during the ongoing LGV epidemics: LGV infection affected mostly HIV-positive MSM patients; the anorectal infection was the predominant one, with moderate-to-severe proctitis representing the most prevalent clinical presentation. 14,15,17,18 We highlight the presence of 14.3% asymptomatic patients, which is somewhat lower than the value reported in literature. 3,16,17 The rate of STI co-infections was particularly high (58.9%) in our population, although similar rates of STI co-infections have been described within the ongoing LGV epidemics.…”

Section: Discussioncontrasting

confidence: 63%

Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon Tertiary Center

Neves

Pinheiro

Côrte‐Real

et al. 2021

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Lymphogranuloma venereum (LGV) is a sexual transmitted infection (STI), currently endemic within the population of men who have sex with men (MSM) of Western Countries. L2B variant has been reported as the predominant strain in the current LGV epidemics, although a shift towards L2-434 has been observed in some European countries.Objectives To evaluate and characterize the population with LGV infection diagnosed in Centro Hospitalar Universit ario de Lisboa Central, Lisbon, Portugal.Methods A retrospective analysis of all LGV diagnoses between 2016 and 2019 was performed. The diagnosis was established through ompA-genotyping of samples yielding a positive result to Chlamydia trachomatis (CT). All considered samples were retrieved from the clinician activity, through swabbing and urine analysis and CT infection diagnosis was obtained using real-time PCR.Results During the period studied 16 279 CT diagnostics tests were employed, with a striking increase from 2016 (n = 467) to 2019 (n = 9362). A total of 1602 diagnoses of CT were established, from which 168 (10.5%) corresponded to LGV, with both infections showing a rising evolution, between 2016 and 2019, of 2.9 and 2.7 times, respectively. The majority of the LGV strains were genotyped as L2/434 (67.3%; n = 113). LGV predominantly affected MSM and men who have sex with men and women (97.0%; n = 163). Anorectal infection was the most prevalent one (90.5%; n = 152), being proctitis the main clinical presentation (76.2%; n = 128). Absence of symptoms was reported in almost 15% of the cases (n = 24). The presence of concomitant infection with human immunodeficiency virus was dominant (73.2%; n = 123) and the prevalence of one or more STI co-infections was about 60.1% (n = 99).Conclusions An increasing evolution of CT and LGV testing and diagnosing was observable throughout the studied period. Characteristics of the population are similar with those described within LGV epidemics. In accordance with recent European studies, predominance towards L2 genotype was identified.

show abstract

Section: Discussioncontrasting

confidence: 63%

Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon Tertiary Center

Neves

Pinheiro

Côrte‐Real

et al. 2021

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Similar to the trend seen in the UK, between 2010 and 2016 increased LGV diagnoses were also reported in France, the Netherlands, Belgium and the Republic of Ireland, 6,26,27 and both France and the Republic of Ireland saw a decrease in diagnoses from 2016 to 2017 27 (C Bebear, pers. comm.…”

Section: Discussionsupporting

confidence: 60%

“…Acquisition was associated with reported behaviours such as condomless anal intercourse; fisting and the use of sex toys; and the increased use of chemsex drugs and group sex facilitated by geospatial networking applications. [4][5][6][7][8][9] The increase in LGV diagnoses seen between 2009 and 2016 was consistent with trends of other STIs in England. Diagnoses of chlamydia, syphilis and gonorrhoea seen in those attending sexual health services increased by 26%, 178% and 280% respectively and, among MSM, by 338%, 234% and 642% respectively.…”

Section: Introductionsupporting

confidence: 69%

Investigating the decline in Lymphogranuloma venereum diagnoses in men who have sex with men in the United Kingdom since 2016: an analysis of surveillance data

et al. 2020

View full text Add to dashboard Cite

Background Following an upward trajectory in Lymphogranuloma venereum (LGV) diagnoses in the UK from 2004 to 2016, with annual diagnoses increasing from 28 to 904, diagnoses fell to 641 in 2017; this was inconsistent with the upward trend in other bacterial sexually transmissible infections (STIs) between 2016 and 2017. An analysis of surveillance data from multiple sources to investigate the possible factors contributing to this decline in LGV was performed. Methods: LGV tests and diagnoses in the UK from 2004 to 2018 were captured through laboratory data from the LGV Reference Laboratories and laboratories conducting in-house LGV testing. These data and clinical diagnoses data from England were analysed alongside the national management guidelines issued over the course of the epidemic. Results: LGV diagnoses increased between 2004 and 2015 and then decreased between 2016 and 2018. LGV testing increased from 2010 to 2018 (2690–10850). Test positivity halved between 2015 (14.8%, 929–6272) and 2018 (7.3%, 791–10850). Peaks in LGV testing and diagnoses appeared to coincide with the publication of national LGV management guidelines and changes to clinical practice. The proportion of LGV diagnoses among HIV-positive men who have sex with men (MSM) fell between 2013 and 2018 (74–48%). Conclusions: The fall in diagnoses and positivity were likely due to increasing earlier clinical diagnosis and treatment. Changes to the national management guidelines, the clinical policy and practice of some larger clinics and potentially changes to the guidelines for the treatment of chlamydia broadened the scope of testing and increased testing in asymptomatic patients which, in combination, likely had a positive effect on the control of LGV infection.

show abstract

“…But the most surprising fact was the detection of the L1 genotype, 10 which had not been reported worldwide in literature since the 1980s. 11 In the present series, although L2b was the most frequent genotype diagnosed in North American and European countries, 12,13 L1 was detected in almost one-third of LGV positive patients, being more frequent than L2. This particular genotype’s profile on the Argentine outbreak highlights a different distribution pattern of anorectal LGV infection.…”

Section: Discussioncontrasting

confidence: 51%

Chlamydia trachomatis anorectal infections by LGV (L1, L2 and L2b) and non-LGV serotypes in symptomatic patients in Buenos Aires, Argentina

et al. 2021

View full text Add to dashboard Cite

Background Chlamydia trachomatis (CT) can infect the anorectum producing various signs and symptoms. There is scarce literature regarding the differences between LGV and non-LGV CT anorectal manifestations. We compare the clinical spectrum of LGV and non-LGV infections. Methods Patients over 18 years with presumptive infectious anorectal symptoms were examined in two healthcare centres in Buenos Aires. The patients were studied and treated according to current sexually transmitted infection guidelines. Anorectal swabs were collected to detect and genotype CT. Results A three-year-long study on 317 patients with anorectal symptoms showed 45.11% CT infection (85% LGV strains). Of 140 samples, 92 were sequenced: 80/119 LGV (L2b 45%, L1 32.5% and L2 22.5%) and 12/21 non-LGV. Older age and HIV+ status were significantly higher in the LGV group. Anal discharge, bleeding, severe proctitis and anal ulcers were more common in the LGV group. Multivariate logistic regression analysis revealed that HIV infection, anorectal bleeding and oro-anal sex are independent predictors of LGV infection. Conclusions In patients with anorectal symptoms, LGV serovars predominate over non-LGV ones. Clinical manifestations are not pathognomonic of a specific biovar. If genotyping is not available, having clinical predictors may help to presume an LGV infection and define length of treatment.

show abstract

Lymphogranuloma venereum in Quebec: Re-emergence among men who have sex with men

Cited by 10 publications

References 23 publications

Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon Tertiary Center

Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon Tertiary Center

Investigating the decline in Lymphogranuloma venereum diagnoses in men who have sex with men in the United Kingdom since 2016: an analysis of surveillance data

Chlamydia trachomatis anorectal infections by LGV (L1, L2 and L2b) and non-LGV serotypes in symptomatic patients in Buenos Aires, Argentina

Contact Info

Product

Resources

About