Lymphoid malignancies following kawasaki disease

Murray, Jeffrey C.; Bomgaars, Lisa; Carcamo, Benjamin; Mahoney, Donald H.

doi:10.1002/ajh.2830500414

Cited by 15 publications

(11 citation statements)

References 7 publications

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“…[30][31][32] In the current study, the SMRs for malignancy were elevated slightly, but with a lack of significance. From this point of view as well, the follow-up should be continued.…”

Section: Discussionmentioning

confidence: 89%

Mortality Among Persons With a History of Kawasaki Disease in Japan Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population

Nakamura

Aso

Yashiro

et al. 2008

Circ J

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BackgroundThe long-term prognosis of those having a history of Kawasaki disease (KD) is still unknown. Methods and Results Between July 1982 and December 1992, 52 collaborating hospitals collected data on all patients having a new definite diagnosis of KD. Patients were followed-up until December 31, 2004 or their death. Standardized mortality ratios (SMRs) were calculated based on the Japanese vital statistics data. Of 6,576 patients enrolled, 36 (27 males, 9 females) died and the SMR was 1.14. Despite the high SMRs during the acute phase, the mortality rate was not high after the acute phase for the entire group of patients. Although the SMR after the acute phase was 0.71 for those without cardiac sequelae, 10 males (but none of the females) with cardiac sequelae died during the observation period; and the SMR for the male group with cardiac sequelae was 2.55 (95% confidence interval: 1.23-4.70). Conclusions The mortality rate among males with cardiac sequelae because of KD was significantly higher in this cohort than in the general population. On the other hand, those for females with the sequelae and for both males and females without sequelae were not elevated. (Circ J 2008; 72: 134 -138)

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“…[30][31][32] In the current study, the SMRs for malignancy were elevated slightly, but with a lack of significance. From this point of view as well, the follow-up should be continued.…”

Section: Discussionmentioning

confidence: 89%

Mortality Among Persons With a History of Kawasaki Disease in Japan Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population

Nakamura

Aso

Yashiro

et al. 2008

Circ J

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“…This possibility was ruled out in our patient by liver biopsy. The course of the illness can also mimic malignancy, such as lymphoid malignancy, which was reported shortly following the diagnosis of KD in 2 children [9]. Other possibilities are severe sepsis and toxic shock syndrome [10].…”

Section: Discussionmentioning

confidence: 98%

Hemophagocytosis Complicating Kawasaki Disease

Al-Eid¹,

Al‐Jefri²,

Bahabri³

et al. 2000

Pediatric Hematology and Oncology

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A 6-year-old boy developed hemophagocytic syndrome during the recurrent course of Kawasaki disease. Despite the appropriate treatment modalities for Kawasaki disease, he developed pancytopenia, marked hepatosplenomegaly, high-grade fever, hyperferritinemia, hypertriglyceremia, and evidence of hemophagocytosis in the liver biopsy. Although the course was stormy, he responded well to a combination therapy of corticosteroids, etoposide VP16, and granulocyte colony-stimulating factor G-CSF. The clinical course and the treatment given were compared with the previous reported cases.

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“…However, the relationship between KD and malignancies remains unclear. There are only a few reports of malignant neoplasms associated with KD [2][3][4]. This association suggests that there may be a relationship between immunological disorder in KD and the development of malignancy.…”

Section: Discussionmentioning

confidence: 98%

“…However, immunological abnormalities in the acute phase of KD are well documented and may be pathogenic in the known cardiac and noncardiac complications of the disease. Despite the well-known association between acquired immunodeficiency states and neoplasia, there are only a few reports of malignant neoplasms accompanying or following the onset of this disease [2][3][4]. We report here an exceptional case of KD associated with Mycoplasma pneumoniae infection and complicated by anaplastic large cell lymphoma in a young girl.…”

Section: Introductionmentioning

confidence: 90%

“…However, if linking M. pneumoniae to KD is actually considered that is a possible trigger [5][6][7][8][9], relationship between KD and malignancies remains unclear and controversial. The hypothesis that there may be an unrecognized peri-malignant syndrome of signs and symptoms is discussed by Murray et al [2]. Clinicians must rely on the presence of specific clinical criteria and laboratory data, excluding other illnesses that can mimic the disease [10].…”

Section: Discussionmentioning

confidence: 99%

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Kawasaki disease, <i>Mycoplasma pneumoniae</i> infection and anaplastic large cell lymphoma: An uncommon association

Chemli¹,

Hassayoun²,

Ketata³

et al. 2012

OJPed

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Kawasaki disease (KD) is an acute febrile systemic vasculitis occurring predominantly in young children less than 5 years of age. Although imperfectly known, the aetiopathogenesis of KD would be secondary to immunological abnormalities that could constitute a favourable terrain for neoplasms. We report on a case in a 2-year-old girl who presented clinical manifestations compatible with Kawasaki disease complicated by coronary aneurysm. Aetiopathological investigations revealed M. pneumoniae infection as specific IgM were present in the serum (Elisa). The patient was initially treated by intravenous immunoglobulins (IVIG) and aspirin to anti-inflammatory dose. Following a few days of desquamation, resolution of the symptomatology occurred. Four weeks later she developed disseminated tumorous syndrome. Lymph node biopsy revealed massive infiltration by large cells lymphomatous proliferation. Histologic and immunophenotypic findings were characteristic of ALK-1 + anaplastic large cell lymphoma. Four weeks later, the patient died from a severe nosocomial infection complicated by septic shock. Our observation is the first cases describing the association between anaplastic large cell lymphoma, KD and M. pneumoniae. Immunologic disorder due to KD and M. pneumoniae infection may play probably a central role for malignancy.

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Lymphoid malignancies following kawasaki disease

Cited by 15 publications

References 7 publications

Mortality Among Persons With a History of Kawasaki Disease in Japan Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population

Mortality Among Persons With a History of Kawasaki Disease in Japan Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population

Hemophagocytosis Complicating Kawasaki Disease

Kawasaki disease, <i>Mycoplasma pneumoniae</i> infection and anaplastic large cell lymphoma: An uncommon association

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Lymphoid malignancies following kawasaki disease

Cited by 15 publications

References 7 publications

Mortality Among Persons With a History of Kawasaki Disease in Japan Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population

Mortality Among Persons With a History of Kawasaki Disease in Japan Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population

Hemophagocytosis Complicating Kawasaki Disease

Kawasaki disease, &lt;i&gt;Mycoplasma pneumoniae&lt;/i&gt; infection and anaplastic large cell lymphoma: An uncommon association

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Kawasaki disease, <i>Mycoplasma pneumoniae</i> infection and anaplastic large cell lymphoma: An uncommon association