Lymphoma

Ness, SallyAnne L.

doi:10.1002/9781119086512.ch20

Cited by 2 publications

(16 citation statements)

References 66 publications

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“…However, leukaemia is occasionally reported in advanced cases. (Muñoz et al 2009, Ness 2016. Leukaemia may be primary when the neoplasm originates in the bone marrow and neoplastic cells are released into the peripheral circulation.…”

Section: Introductionmentioning

confidence: 99%

“…Paraneoplastic syndromes are often the earliest detectable evidence of lymphoma and may include generalised pruritus, undulant pyrexia, cachexia, hypercalcemia and erythrocytosis (Axiak andJohnson 2011, Taintor andSchleis 2011). The total white blood cell count (WBC) is seldom diagnostically helpful since most cases of equine lymphoma are non-leukaemic (Ness 2016). However, leukaemia is occasionally reported in advanced cases.…”

Section: Introductionmentioning

confidence: 99%

“…The clinical signs are often nonspecific and depend upon the type of tumour and the affected organ(s) (Janvier et al 2016, Ness 2016. Paraneoplastic syndromes are often the earliest detectable evidence of lymphoma and may include generalised pruritus, undulant pyrexia, cachexia, hypercalcemia and erythrocytosis (Axiak andJohnson 2011, Taintor andSchleis 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Lymphoma is the most common malignant hematopoietic neoplasm in the horse (Muñoz et al 2009, Janvier et al 2016, Ness 2016, with a reported incidence of between 1% and 3 % of all equine tumours (Janvier et al 2016, Taintor andSchleis 2011). Equine lymphoma arises from lymphoid tissue and is conventionally categorized according to the distribution of tumour lesions as alimentary, cutaneous, mediastinal or multicentric (Schwarz et al 2012, Ness 2016, Taintor and Schleis 2011.…”

Section: Introductionmentioning

confidence: 99%

“…Equine lymphoma arises from lymphoid tissue and is conventionally categorized according to the distribution of tumour lesions as alimentary, cutaneous, mediastinal or multicentric (Schwarz et al 2012, Ness 2016, Taintor and Schleis 2011.…”

Section: Introductionmentioning

confidence: 99%

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Advanced multicentric lymphoma in a Belgian Draft Horse mare

Siegers¹,

Oosterbaan²,

Wollenberg³

et al. 2017

PHK

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Summary: A 15-year old draft horse mare was presented to the University Clinic for evaluation of lethargy, anorexia, ptyalism, weight loss and ventral oedema. Clinical examination and rectal palpation revealed generalised lymphadenopathy and numerous firm subcutaneous and abdominal masses of various sizes. Transcutaneous ultrasonography revealed significant bilateral pleural fluid accumulation and a single hypoechoic structure in the abdomen lateral to the liver. Blood analysis showed several abnormalities including a marked leucocytosis with an increased number of segmented neutrophils, atypical lymphocytes and monocytosis, suggestive of leukaemic lymphoma. A significant hyperproteinaemia with a hypoalbuminemia and a monoclonal gammopathy was identified. At necropsy myriad masses presented through the whole body. Histology confirmed the suspicion of lymphoma, which was classified as a T-cell rich B-cell multicentric lymphoma. This article describes the clinical and pathologic findings of this case of leukaemic lymphoma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Advanced multicentric lymphoma in a Belgian Draft Horse mare

Siegers¹,

Oosterbaan²,

Wollenberg³

et al. 2017

PHK

View full text Add to dashboard Cite

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A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings

Silva,

Ribeiro,

Cunha

et al. 2024

Open Vet J

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Background: Although relatively uncommon, lymphoma is the most prevalent haematopoietic neoplasia in horses, and multicentric lymphoma remains the most common presentation of the disease. The pathogenesis of equine lymphoma is still poorly understood and the diagnosis is usually confirmed at an advanced stage of the disease, compromising the prognosis. This study investigated the clinical, pathological and molecular features of a case of equine multicentric lymphoma. Case Description: An apparently healthy 5-year-old crossbreed mare hospitalized at Centre of Animal Reproduction of Vairão (CRAV), Portugal, suddenly presented clinical signs of supraorbital oedema and mandibular lymph node enlargement, developing fever, facial oedema and generalized lymphadenopathy. The mare ended up dying twenty-four days after the first clinical signs due to multisystem organ failure. Haematological and biochemical analyses, necropsy and microscopic and molecular evaluation of affected tissues were performed. At necropsy, the main findings were multiple multinodular lesions, distributed along the serous surface of oropharynx, trachea, pericardium, gastrointestinal tract and mesentery. Microscopically, these consisted of solid proliferations of neoplastic round cells that exhibited immunopositivity for CD3 (T cells). Based on these findings, a medium-grade multicentric T-cell lymphoma was diagnosed. Conclusion: There is still very little research regarding the molecular characterization of lymphoma in horses. As an entity itself quite heterogeneous, it is important to describe the interspecies particularities to understand its development and behaviour.

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Lymphoma

Cited by 2 publications

References 66 publications

Advanced multicentric lymphoma in a Belgian Draft Horse mare

Advanced multicentric lymphoma in a Belgian Draft Horse mare

A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings

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