Lymphoma and systemic sclerosis — an uncommon association or possible coincidence of two disorders with a fatal outcome

Nephrogenic Systemic Fibrosis with Multiorgan Involvement in a Teenage Male after Lymphoma, Ewing's Sarcoma, End-Stage Renal Disease, and Hemodialysis

“…We could find no reports linking NSF with chemotherapy or occurring in the absence of chronic renal failure. However, there are reports of progressive systemic sclerosis (scleroderma) associated with Hodgkin's lymphoma treated with ABV and with cyclophosphamide, doxorubicin, vincristine, and prednisolone [32]; non-Hodgkin's lymphoma treated with cyclophosphamide, adriamycin, and prednisone [33]; and breast cancer treated with doxorubicin and cyclophosphamide [34]. Although it is impossible to prove that the skin disease and contractures in our case were not related to his chemotherapy, it seems very unlikely considering he had received a 1st course of chemotherapy 7 years before with no subsequent skin changes.…”

Coincidental association of mycosis fungoides and occupational systemic sclerosis?

“…12 Aberrated immune functions caused by cytokines, growth factors, hormones, antigen presentation or antibodies have been suggested to be related to the development of SSc in patients suffering from malignancy. 13 Although malignant lymphomas associated with SSc have been described in several reports, [13][14][15] SSc preceded malignant lymphoma in most cases. Hasegawa et al reviewed published reports of 16 cases of SSc with malignant lymphoma.…”

Autoimmune Disorders and Lymphomas

“…This association was first proposed in 1953 (ZATUCHNI et al, 1953) and successively several epidemiological studies have been performed to explore this risk (Chatterjee et al, 2005, Hill et al, 2003, Duncan & Winkelmann, 1979. A number of sporadic case reports have underlined the association between SSc and NHL, particularly with aggressive B-cell subtypes (Arnaud et al, 2006, Derk et al, 2004, Haviv et al, 1997 and some authors observed an increased risk of NHL among SSc patients, primarily within the first year after the onset of disease, but not beyond 4 years of follow up (Landgren et al, 2006, Mellemkjaer et al, 2008, Rosenthal et al, 1993. Conversely, other studies failed to demonstrate a consistent association between SSc and lymphomas (Chatterjee et al, 2005, Rosenthal et al, 1995, Roumm & Medsger, 1985.…”