Lymphoma arising in Paget′s disease

Yu, Thomas; Squires, Fredric; Mammone, Joseph F.; DiMarcangelo, Mark T.

doi:10.1007/s002560050320

Cited by 10 publications

(1 citation statement)

References 2 publications

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“…Other neoplastic conditions that may coexist with Paget disease include metastatic disease, lymphoma, leukemia, or multiple myeloma, although this association may be fortuitous (2)(3)(4)(5)(6)(7)71,72,89,97). The differentiation of these neoplastic conditions from sarcomatous transformation is difficult unless they involve bone not affected by the Paget disease.…”

Section: Neoplastic Complications Of Paget Diseasementioning

confidence: 99%

From the Archives of the AFIP

Smith¹,

Murphey²,

Motamedi³

et al. 2002

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Paget disease of bone is a common disorder affecting approximately 3%-4% of the population over 40 years of age. The pathologic abnormality in Paget disease is excessive and abnormal remodeling of bone. Three pathologic phases have been described: the lytic phase (incipient-active), in which osteoclasts predominate; the mixed phase (active), in which osteoblasts cause repair superimposed on the resorption; and the blastic phase (late-inactive) in which osteoblasts predominate. Radiographic appearance of Paget disease reflects these pathologic changes and is often characteristic. Initially, there is osteolysis, particularly affecting the skull (osteoporosis circumscripta) and subchondral long bones, with subsequent development of trabecular and cortical thickening and enlargement of bone in the mixed phase of the disease. Finally, areas of sclerosis may develop in the blastic phase. Frequent sites of involvement include the skull (25%-65% of cases), spine (30%-75%), pelvis (30%-75%), and proximal long bones (25%-30%). Bone scintigraphy typically demonstrates marked increased uptake of radionuclide in all phases of Paget disease. Computed tomography and magnetic resonance imaging often show changes similar to those seen radiographically in noncomplicated Paget disease with maintenance of yellow marrow. Complications of Paget disease include the effects of osseous weakening (deformity and fracture), arthritis, neurologic symptoms, and neoplastic involvement. Sarcomatous transformation is the most feared complication, occurring in approximately 1% of cases, and is seen on images as focal bone destruction extending through the cortex with an associated soft-tissue mass. Recognition of the radiologic spectrum of the appearances of Paget disease usually allows prospective diagnosis and differentiation of its associated complications, which helps guide therapy and improve patient management.

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Section: Neoplastic Complications Of Paget Diseasementioning

confidence: 99%

From the Archives of the AFIP

Smith¹,

Murphey²,

Motamedi³

et al. 2002

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208

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Paget’s Disease of Bone

Whitehouse¹,

Davies²

Imaging of the Hip &Amp; Bony Pelvis

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Imaging of Paget’s disease of bone

Winn

Lalam

Cassar‐Pullicino

2016

Wien Med Wochenschr

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Paget's disease of bone is a disorder of bone remodelling, leading to changes in the architecture and overall appearance of the bone. The disorder may be monostotic or polyostotic and affect any bone in the body, although most commonly it involves the spine, pelvis, skull and femur. This article explores the different imaging modalities used in the assessment of Paget's disease of bone in its different phases. The relative merits of each imaging modality is discussed with illustrative examples, in particular with respect to radiographs, nuclear medicine bone scan, computed tomography (CT) and magnetic resonance imaging (MRI).

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Lymphoma arising in Paget′s disease

Abstract: We present a case of lymphoma arising in pagetoid bone. The malignant potential of pagetoid bone is well known; however, primary lymphomatous involvement is extremely rare and has only been suggested in a few cases.

Cited by 10 publications

References 2 publications

From the Archives of the AFIP

From the Archives of the AFIP

Paget’s Disease of Bone

Imaging of Paget’s disease of bone

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