Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study

Onishi, Chie; Nishikori, Momoko; Yakushijin, Kimikazu; Kurahashi, Shingo; Nakazawa, Hayakazu; Takamatsu, Yasushi; Hashimoto, Yoshinori; Tatetsu, Hiro; Nawa, Yuichiro; Yoshida, Masahiro; Kobayashi, Tsutomu; Oyake, Tatsuo; Yano, Shingo; Oride, Aki; Suzuki, Ritsuro

doi:10.1007/s12185-021-03281-w

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After titles and abstracts were screened, 76 full‐text articles were reviewed. Authors of five articles, 34 , 35 , 36 , 37 , 38 and three conference abstracts, 39 , 40 , 41 were contacted by email for data specific to HL. Two responses were received; one provided the requested data.…”

Section: Resultsmentioning

confidence: 99%

Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: A systematic review

Houlihan

Buckley

Maher

et al. 2022

BJOG

View full text Add to dashboard Cite

Background The initial peak incidence of Hodgkin lymphoma (HL) occurs during reproductive years. Objectives Synthesise published literature on the relationship between HL and maternal and perinatal outcomes. Search strategy Systematic search of PubMed/Medline, Cochrane Library, Scopus, Embase and Science Direct from inception to June 2022, supplemented by hand‐searching reference lists. Selection criteria Two reviewers independently reviewed titles, abstracts and full‐text articles. Published studies containing original data were eligible. Data Collection and Analysis Two reviewers independently extracted data and appraised study quality. Outcomes for pregnant women with a previous/current diagnosis of HL were compared separately with women never diagnosed with HL. Where data permitted, meta‐analyses of odds ratios and proportions were performed. Certainty of evidence was determined using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Main results Of the 5527 studies identified, 33 met the inclusion criteria. In the groups with HL before pregnancy and HL during pregnancy, adjusted odds ratios were not statistically significant for congenital malformation (aOR 1.7, 95% CI 0.9–3.1, and aOR 1.84, 95% CI 0.81–4.15, respectively), preterm birth (PTB) (aOR 0.99, 95% CI 0.65–1.51, and aOR 6.74, 95% CI 0.52–88.03, respectively) and miscarriage (aOR 0.78, 95% CI 0.55–1.10, and aOR 0.38, 95% CI 0.05–2.72, respectively). The aORs for all other outcomes were not statistically significant, except for blood transfusion (aOR 1.38, 95% CI 1.05–1.82) and venous thromboembolism (VTE) (aOR 7.93, 95% CI 2.97–21.22) in the group for HL during pregnancy. The proportion of anaemia was also increased in this group (69%, 95% CI 57%–80% vs 4%, 95% CI 4%–5%, respectively). The GRADE certainty of findings ranged from low to very low. Conclusions Rates of most adverse pregnancy outcomes among women with a previous/current HL diagnosis are not increased significantly compared with the general pregnant population. Women with HL diagnosed during pregnancy may have a higher PTB rate and increased likelihood of VTE, anaemia and blood transfusion; however, small study numbers and the low to very low GRADE certainty of findings preclude firm conclusions.

show abstract

Section: Resultsmentioning

confidence: 99%

Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: A systematic review

Houlihan

Buckley

Maher

et al. 2022

BJOG

View full text Add to dashboard Cite

show abstract

“…However, it may be worth mentioning that we did not note any significant delays in the diagnosis or initiation of treatment of leukemia due to pregnancy itself. In a previous study of malignant lymphoma during pregnancy, the start of chemotherapy was deferred in approximately 40% of cases [ 27 ]. Our findings may reflect the fact that any delay in the start of induction therapy for acute leukemia may negatively impact on both the patient and their fetus [ 4 , 14 ] and may also reflect the urgent nature of this clinical situation.…”

Section: Discussionmentioning

confidence: 99%

Acute leukemias in pregnant women: Results of a retrospective study at a local tertiary‐care hospital in Japan

Kobayashi

Biyajima

Matsuzawa

et al. 2023

eJHaem

Self Cite

View full text Add to dashboard Cite

Leukemia may rarely develop in a woman during pregnancy, posing clinical challenges to the patient, fetus, family, and medical staff managing malignancy and pregnancy. We retrospectively analyzed cases of pregnancy‐associated leukemia consecutively diagnosed and treated at a local tertiary‐care hospital in Nagano, Japan, over the past 20 years. Five cases were identified among 377,000 pregnancies in the area (one in every 75,000 pregnancies), all involving acute leukemia (three acute myelogenous leukemia [AML] and two acute lymphoblastic leukemia [ALL]). The cases were diagnosed in the first trimester (n = 1), second trimester (n = 3), or third trimester (n = 1). There were no apparent pregnancy‐associated delays in diagnosing and treating the cases. Three patients underwent induction chemotherapy during pregnancy, two of whom eventually delivered healthy babies. One of the five patients chose abortion before chemotherapy initiation. Two cases showing high‐risk features at the diagnosis (AML with an FLT3‐ITD mutation [n = 1] and relapsed ALL [n = 1]) eventually died despite consolidative allogeneic hematopoietic stem cell transplantation. Our results suggested that patients with pregnancy‐associated acute leukemia can be treated similarly to nonpregnant patients, although pregnancy imposes particular clinical challenges that should be resolved with multidisciplinary care.

show abstract

Immunochemotherapy for life-threatening haematological malignancies in pregnancy: a systematic review of the literature and cross-sectional analysis of clinical trial eligibility

Mills

Chadwick

Tang

et al. 2023

The Lancet Haematology

View full text Add to dashboard Cite

Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study

Cited by 3 publications

References 25 publications

Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: A systematic review

Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: A systematic review

Acute leukemias in pregnant women: Results of a retrospective study at a local tertiary‐care hospital in Japan

Immunochemotherapy for life-threatening haematological malignancies in pregnancy: a systematic review of the literature and cross-sectional analysis of clinical trial eligibility

Contact Info

Product

Resources

About