Lymphoma Occurring During Pregnancy: Antenatal Therapy, Complications, and Maternal Survival in a Multicenter Analysis

Abstract

Standard (non-antimetabolite) combination chemotherapy administered past the first trimester, as early as 13 weeks gestation, was associated with few complications and expected maternal survival with lymphoma occurring during pregnancy.

Incidence and outcomes of women with Hodgkin’s lymphoma in pregnancy: a population-based study on 7.9 million births

“…Our results show that the age group at highest risk of HL in pregnancy is 25-34 years. In a recent multicenter analysis of lymphomas occurring during pregnancy over a 13-year period, Evens et al reported on 40 patients diagnosed with HL in pregnancy and similarly found that the mean age at diagnosis was 29 years [9]. This is consistent with the first bimodal peak in disease incidence, occurring in reproductive-aged women.…”

Pregnancy associated nasopharyngeal carcinoma: A retrospective case-control analysis of maternal survival outcomes

“…There is no difference in the survival rates of pregnant and non-pregnant patients in some types of cancer [6,7]. However, previous case reports and small sample studies performed in the 1980s and 1990s indicated that patients with PANPC have a much poorer prognosis than female patients with NPC [8,9].…”

“…Pregnancy complicated by cancer is a relatively rare phenomenon with an incidence of 0.02-0.1% [3]. With the recent trends for women delaying pregnancy into later reproductive years [4] and the higher incidence of NPC in individuals over the age of 30 [5], physicians can expect to see increased numbers of cases of PANPC in the future.There is no difference in the survival rates of pregnant and non-pregnant patients in some types of cancer [6,7]. However, previous case reports and small sample studies performed in the 1980s and 1990s indicated that patients with PANPC have a much poorer prognosis than female patients with NPC [8,9].…”

Disparities in lymphoma on the basis of race, gender, HIV status, and sexual orientation

“…In the largest retrospective study of pregnant lymphoma patients treated with non-anti-metabolite chemotherapy, Evens et al noted an overall response rate of 82% and a complete response rate of 64%, which suggested that pregnant women could be successfully treated with chemotherapy and achieve similar outcomes to non-pregnant patients. Additionally, there was no significant difference in either prenatal or postnatal complications between women treated during the second trimester of pregnancy versus those who deferred treatment until delivery, and a low miscarriage rate of 1.1% was noted (18). A more recent study by Pinnix et al notes an overall miscarriage rate of 10%, but it should be noted that these miscarriages occurred in patients requiring treatment during the first trimester of pregnancy (14,15).…”