Lymphoma of the cervix uteri

Amna, Fatima Abu; Howell, Rosemary; Raj, Shinod

doi:10.1136/bcr.05.2009.1835

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…Primary cervical lymphomas in early stages usually have excellent prognosis with any treatment combination (radiotherapy and/or chemotherapy and/or surgical resection); hence, the aim is to find out the most conservative and least invasive treatment approach [ 36 ]. In this report, we present the first case of DLBCL (I E) of cervix uteri managed with an hysteroscopic approach followed by adjuvant radiotherapy with success.…”

Section: Discussionmentioning

confidence: 99%

Hysteroscopic Resection Followed by Adjuvant Radiotherapy: Report of a New Therapeutic Approach to Primary Cervical Diffuse Large B-Cell Lymphoma

Stabile

Sancin

Bailo

et al. 2022

IJERPH

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The female genital tract can be involved as a secondary manifestation of disseminated lymphomas or leukemia but can rarely be the primary site of so-called extranodal lymphomas. Primary lymphomas of the female genital tract can affect the uterine corpus, uterine cervix, vulva, vagina or adnexa. Only about 0.008% of all cervical tumors are primary malignant lymphomas. The presenting symptoms are unspecific and also refer to much more common diseases of the female genital tract. Cervical cytology is usually negative. Preoperative diagnosis requires deep cervical biopsy. To date there is no consensus regarding optimal treatment. Radiotherapy, chemotherapy and surgery are used in different association. We report the first case reported in literature managed with an urgent hysteroscopic resection of a primary cervical diffuse large B-cell lymphoma, followed by adjuvant radiotherapy. Relevant literature was reviewed. Our conservative approach needs to be validated in the future, especially for women with pregnancy desire and for those with low performance status. To date, after 24 months from diagnosis, our patient is still disease-free.

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Section: Discussionmentioning

confidence: 99%

Hysteroscopic Resection Followed by Adjuvant Radiotherapy: Report of a New Therapeutic Approach to Primary Cervical Diffuse Large B-Cell Lymphoma

Stabile

Sancin

Bailo

et al. 2022

IJERPH

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“…Finding cytological anomalies in this condition is extremely uncommon since diffuse large B-cell lymphoma of the cervix is a stromal disease, and a cytological diagnosis would only be expected when there is ulceration of epithelial cells (5,10).…”

Section: Discussionmentioning

confidence: 99%

Linfoma primario de cuello uterino. Reporte de caso

Mariño

2021

Case reports

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Introducción. El linfoma primario del cuello uterino es una patología infrecuente, de síntomas inespecíficos y que pocas veces altera el examen de citología del cuello uterino dado que se desarrolla en el estroma cervical. Para su tratamiento existen varias opciones, incluyendo quimioterapia, radioterapia y cirugía, así como combinaciones de estas. La localización única del linfoma en el cuello uterino se considera un factor de buen pronóstico. Presentación del caso. Paciente femenina de 49 años, quien consultó por dolor pélvico y flujo y sangrado genital. Se ordenó colposcopia por reporte de ASC-H (células escamosas atípicas que no excluyen lesiones intraepiteliales de alto grado) en citología vaginal. La biopsia reportó linfoma difuso de células B grandes, el cual se trató con rituximab, ciclofosfamida, doxorrubicina, vincristina y prednisolona por tres ciclos, y con rituximab, ifosfamida, carboplatino y etopósido por dos ciclos; este cambio se hizo debido a una mala respuesta con el primer esquema. Se realizó nueva biopsia después del último ciclo de quimioterapia con reporte de pólipo de tipo endocervical y abundantes grupos de células glandulares con atipia focal. Los estudios de imágenes diagnósticas posteriores al tratamiento reportaron engrosamiento concéntrico de la unión entre cuello uterino y vagina. A los 7 años del diagnóstico del linfoma se realizó otra biopsia que resultó negativa para displasia o malignidad. Al momento de la elaboración del presente reporte, 10 años después del diagnóstico, la paciente se encontraba asintomática y libre de enfermedad. Conclusiones. El linfoma primario del cuello uterino es una patología rara que en pocas oportunidades se evidencia con anormalidad en la citología vaginal como en el caso reseñado. Dado este hallazgo se realizó una colposcopia mediante la cual se confirmó el diagnostico de linfoma difuso de células B grandes. Se presenta un caso con evolución satisfactoria y supervivencia libre de enfermedad después de 10 años.

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“…Clinical symptoms of female genital tract lymphoma are often non-specific and mimic other much more common gynecologic pathology. Diagnosis is only confirmed by histology [2] .…”

Section: Discussionmentioning

confidence: 99%

“…Because the neoplasm originates in the submucosal cervical stroma and the overlying squamous epithelium is unaffected, cervical smears are usually normal [2] .…”

Section: Introductionmentioning

confidence: 99%

The importance of re-examination with deep biopsies in diagnosing cervical malignancies despite multiple negative pathology reports: A case report

Ameri

Memarian

Behtash

et al. 2015

International Journal of Surgery Case Reports

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HighlightsThe role of gynecological examination in diagnosis genital cancer is important as in this case (a woman with stony cervix and frozen pelvis).When we have frozen pelvis and fix stony cervix, taking multiple deep biopsies in spite of previous negative pathologic reports, is necessary.Reviewing the slides by qualified pathologists can help us to achieve true diagnosis when we the physical exam does not match with histopatologic results.Lymphoma should be always in our mind to remind the pathologists.

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Lymphoma of the cervix uteri

Cited by 6 publications

References 8 publications

Hysteroscopic Resection Followed by Adjuvant Radiotherapy: Report of a New Therapeutic Approach to Primary Cervical Diffuse Large B-Cell Lymphoma

Hysteroscopic Resection Followed by Adjuvant Radiotherapy: Report of a New Therapeutic Approach to Primary Cervical Diffuse Large B-Cell Lymphoma

Linfoma primario de cuello uterino. Reporte de caso

The importance of re-examination with deep biopsies in diagnosing cervical malignancies despite multiple negative pathology reports: A case report

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