Lymphoma of the parotid gland

Abstract

In a consecutive group of 452 patients undergoing parotid surgery at this institution, 18 (4%) were found to have lymphoma. Review and analysis of presenting symptoms, predisposing factors, histopathology, postsurgical morbidity, and long-term outcome with treatment are presented. The current literature on parotid lymphoma is reviewed, and management strategies are outlined. Although a relatively uncommon primary lesion, lymphoma must be considered in the differential diagnosis of any mass presenting in the parotid gland.

Primary Salivary Gland Lymphoma: A Clinicopathologic Study of 23 Cases in Taiwan

“…NHL of the salivary gland usually presents as a painless, progressively enlarging mass [1, 2, 4, 6, 8, 9, 10]. Therefore, it was rarely suspected before biopsies or surgical removal.…”

“…The parotid gland was most frequently involved, followed by the submandibular gland, minor salivary glands and sublingual gland [1, 2, 4, 5, 6, 7]. Some studies focused on parotid NHL [8, 9, 10]. Although many papers were published on this subject, the majority of them used the histological classifications of Rappaport or Working Formulation, which did not include the category of mucosa-associated lymphoid tissue (MALT) lymphomas [1, 2, 4, 5, 8, 10].…”

“…Some studies focused on parotid NHL [8, 9, 10]. Although many papers were published on this subject, the majority of them used the histological classifications of Rappaport or Working Formulation, which did not include the category of mucosa-associated lymphoid tissue (MALT) lymphomas [1, 2, 4, 5, 8, 10]. MALT lymphoma is now incorporated in the Revised European-American Lymphoma (REAL) and the World Health Organization (WHO) classification systems as a new entity [11, 12]and is the most common lymphoma involving the salivary glands in a recent report [6].…”

“…MALT lymphoma is now incorporated in the Revised European-American Lymphoma (REAL) and the World Health Organization (WHO) classification systems as a new entity [11, 12]and is the most common lymphoma involving the salivary glands in a recent report [6]. In addition, salivary gland lymphomas are frequently associated with myoepithelial sialadenitis (MESA) and autoimmune diseases, especially Sjögren’s syndrome (SS) [1, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 16, 17, 18]. The transformation from MESA to salivary gland lymphoma has been documented [14].…”

Primary Non-Hodgkins lymphoma of the parotid gland

“…Patients with stage I intermediate to high-grade NHL or stage II low-grade disease can benefit from RT alone 8,9,28,30 . The local control rate reached with RT in management of lymphomas is very high as reported by several studies 33,34 .…”