Lymphoma of the prostate treated with radiotherapy

Ghose, Abhimanyu; Baxter-Smith, D. C.; Eeles, H.; Udeshi, U. L.; Priestman, T. J.

doi:10.1016/s0936-6555(05)80818-0

Cited by 18 publications

(8 citation statements)

References 4 publications

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“…Indeed, a number of more recent case studies have reported good outcomes for patients with high-grade primary prostatic lymphoma treated with anthracycline-based chemotherapy with or without radiotherapy [2,10,11]. Other cases with localised diffuse large B-cell lymphoma were managed successfully with radiotherapy only [12]. Rituximab in combination with CHOP regimen is considered as the standard treatment for patients with advanced stage DLBCL [13].…”

Section: Discussionmentioning

confidence: 99%

“…In one review of 23 cases of Japanese primary prostatic lymphoma the authors suggest that patients with this malignancy respond well to chemotherapy and could possibly be cured when the disease is confined to prostatic region [14]. Others authors suggest that prognosis of these malignancies dependent on the histological type and stage of the individual tumour, as it is the case of other non-Hodgkin's lymphomas [12]. In concordance with theses conclusions, the prognosis and treatment of other extra nodal lymphoma are the same as that of nodal lymphomas [13,15].…”

Section: Discussionmentioning

confidence: 99%

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Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Taleb

Ismaili

Belbaraka

et al. 2009

Cases J

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IntroductionPrimary lymphoma of the prostate is very rare. In this paper we present a case of early stage non-Hodgkin lymphoma of the prostate managed with six cycles of rituximab-based chemotherapy, and review the related literature.Case presentationAn 84-year-old man was admitted to our hospital having signs and symptoms suggestive of prostatic disease for 3 years. Histological and immunocytochemical studies of trans-urethral biopsy of the prostate showed diffuse large B-cell lymphoma. Radiological assessment of disease confirmed the diagnosis of early stage lymphoma of the prostate. The patient was managed by 6 of rituximab 375 mg/m2 on day 1, cyclophosphamide 750 mg/m2 on day 1, doxorubicin 50 mg/m2 on day 1, vincristine 1.4 mg/m2 on day 1, and prednisone 50 mg/m2 on days 1 to 5 with complete clinical and radiological response. He remained disease free, until now, 30 months after the end of chemotherapy.ConclusionAccording to the literature, the treatment and prognosis of primary lymphoma of the prostate is the same as that of other nodal lymphomas. Rituximab-based regimen should be considered in the management of prostatic diffuse large B-cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Taleb

Ismaili

Belbaraka

et al. 2009

Cases J

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“…Prostatic lymphoma is rare in men and may present as either primary extranodal lymphoma or as secondary spread to the prostate from other sites 8,9 . The literature describing prostatic lymphoma in men is limited to a number of case reports and case series 10–30 . Patients are often older, although prostatic lymphoma has been reported in patients as young as 5 years of age 8 .…”

Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis—urinary Obstruction Secondary to Prostatic Lymphoma in a Young Dog

Winter

Locke

Penninck

2006

Vet Radiology Ultrasound

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A 3-year old, intact male Doberman pinscher was examined at the Foster Hospital for Small Animals at Tufts University for a 2-week history of stranguria, dyschezia, and weight loss. Ultrasonographically, there was bilateral hydronephrosis, right-sided hydroureter, hepatosplenomegaly, symmetric mild prostatomegaly, and a distended urinary bladder. Fine needle aspirates and biopsies of the prostate yielded a diagnosis of lymphoma. Lymphoma is a rare cause of prostatomegaly in the dog. Sonographic findings are nonspecific; fine needle aspirates or biopsies are needed to ascertain the diagnosis.

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“…Since the 1985 study of Bostwick and Mann,2 at least 19 additional cases of non‐Hodgkin's lymphoma have been reported. Thirteen were primary to the prostate12‐24 and 6 involved other organs25‐30 including 1 case in which the primary tumor was located in the testis and secondarily involved the prostate. 25 Primary prostatic cases most likely have been preferentially reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Malignant lymphoma involving the prostate

Bostwick

Iczkowski

Amin

et al. 1998

Cancer

133

149

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BACKGROUND Malignant lymphoma involving the prostate is rare, and to the authors' knowledge the factors determining patient outcome have not been studied in a large series. METHODS The authors evaluated the clinical and pathologic findings in 60 cases of non‐Hodgkin's lymphoma and 2 cases of Hodgkin's lymphoma involving the prostate. A variety of clinical and histologic findings were considered as factors predictive of patient outcome. RESULTS Lymphoma tended to occur in elderly men, with a mean age at diagnosis of 62 years (range, 5‐89 years), although 6 patients were age < 40 years (ages 5, 19, 30, 32, 38, and 38 years, respectively). Clinical signs and symptoms were due to lower urinary tract obstruction. Twenty‐two patients (35%) presented with primary extranodal lymphoma of the prostate with a variety of histologic subtypes, including small lymphocytic (4 patients); follicular center cell, diffuse, small cell (2 patients); follicular center cell, Grade 1 (according to the revised European‐American classification (small cleaved) (1 patient); Grade 2 (mixed) (1 patient); diffuse large B‐cell (12 patients); and high grade B‐cell lymphoma, Burkitt‐like (2 patients). At the time of presentation, none of these patients had hepatosplenomegaly, inguinal lymphadenopathy, or an abnormal complete blood count. Thirty other patients (48%) with previously documented lymphoma at other sites developed prostatic involvement; these secondary prostatic lymphomas displayed a variety of subtypes, including small lymphocytic (8 patients, all with concomitant leukemia); follicular center cell lymphoma, diffuse, small cell (2 patients); follicular center, Grade 1 (small cell) (1 patient); follicular center, Grade 2 (1 patient); diffuse large B‐cell (11 patients); peripheral T‐cell lymphoma (2 patients); high grade B‐cell lymphoma, Burkitt‐like (1 patient); Burkitt's lymphoma (1 patient); Hodgkin's lymphoma (nodular sclerosing [1 patient] and mixed cellularity [1 patient]); and unknown (1 patient). Ten cases were not classifiable as primary or secondary lymphomas. Twenty‐five patients died of malignant lymphoma, 14 died of unknown or other causes, 18 patients were alive 12‐20 months after diagnosis (8 primary and 10 secondary tumors; 3 had persistent lymphoma; all treated since 1981), and 5 were lost to follow‐up. Lymphoma specific survival was 64% at 1 year (95% confidence interval [CI], 51‐80%), 50% at 2 years (95% CI, 36‐68%), 33% at 5 years, 33% at 10 years, and 16% at 15 years. There was no difference in median survival after diagnosis of prostatic involvement between primary and secondary lymphoma (23 months vs. 28 months, respectively) or among histologic types. CONCLUSIONS Although malignant lymphoma involving the prostate is rare, it should be considered in the differential diagnosis of lower urinary tract obstruction, particularly in patients with a previous history of lymphoma. Cancer 1998;83:732‐738. © 1998 American Cancer Society.

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Lymphoma of the prostate treated with radiotherapy

Cited by 18 publications

References 4 publications

Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Imaging Diagnosis—urinary Obstruction Secondary to Prostatic Lymphoma in a Young Dog

Malignant lymphoma involving the prostate

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