Lymphoma Presenting as Cancer of the Glans Penis: A Case Report

Abstract

Penile lymphoma is a very rare neoplasm. We report the case of an 82-year-old man who presented with phimosis. The patient also complained of frequent and painful urination. Upon examination a painless penile ulcer and multiple enlarged inguinal lymph nodes were found. The shaft of the penis and the prostate were hard on palpation. Abdominal and transrectal ultrasound examination confirmed the involvement of the penis shaft and the prostate and also revealed involvement of the urinary bladder. Biopsy showed diffuse, large B-cell lymphoma. The patient was treated with systemic chemotherapy with full remission of the disease. We review the literature relevant to penile lymphoma and discuss this uncommon condition.

Presentation of Diffuse Large B-Cell Lymphoma Relapse as a Penile Mass

“…Presentation with a primary penile mass is extremely rare for lymphomas, as reported only in case reports in the literature [2,3,4,5,6,7]. Here we report a case of recurrent lymphoma presenting with a penile mass lesion.…”

“…Systemic chemotherapy according to the subtype is a good treatment option because it preserves penile functions [2]. In our patient, R-CHOP therapy was initiated within 2 weeks after admission and obstructive symptoms were relieved immediately after the first course.…”

“…The classical extranodal involvements sites are the breast, central nervous system, and testes. Penile involvement is a rare entity reported in case reports [2,5,7,8,9,10]. Chu et al reviewed penile lymphomas and reported only 48 cases, among which DLBCL was the most frequent subtype with 14 cases [5].…”

A report of two deep-seated noncutaneous penile tumors: more than meets the eye

“…Primary penile lymphoma is extremely rare, with fewer than 30 reported cases identified by our literature search [10] , [11] , [12] , [13] . Primary penile lymphoma would only be considered in the absence of evidence of systemic disease elsewhere such as lymphadenopathy, other sites of visceral involvement, or a known history of lymphoma.…”

A New Technique to Map the Lymphatic Distribution and Alignment of the Penis

“…They are also vital tissues through which the penis skin is involved in the body's immune response. Clinically, many factors such as surgical injury and tumor embolus may lead to poor lymphatic drainage of the penis, resulting in penile foreskin edema (Apesos and Anigian, 1991;Nelson et al, 2004;Stamatiou and Pierris, 2012). Currently, distribution of lymphatic vessels in the penis has not been clearly characterized, mainly due to the lack of methods for studying lymphatic vessels of small diameters (Riveros et al, 1967).…”