Lymphoma risk in livestock farmers: Results of the Epilymph study

Abstract

We explored the risk of lymphoma and its most prevalent subtypes associated with occupational contact with livestock, and whether risk was modified by age at first contact, in 2,348 incident lymphoma cases and 2,462 controls who participated in the EPILYMPH case-control study. A detailed occupational history was collected in cases and controls, including working in a livestock farm, species of livestock, its approximate number and circumstances of contact. For each disease outcome, and each type of livestock, odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for age, gender, education and center. Lymphoma risk (all subtypes combined) was not increased amongst those exposed to contact with any livestock (OR 5 1.0, 95% CI 0.8-1.2). Overall, we did not observe an association between occupational contact with livestock and risk of lymphoma (all types) and B-cell lymphoma. The risk of diffuse large B cell lyphoma (DLBCL) was significantly lower amongst subjects who started occupational contact with any species of livestock before or at age 12 (OR 5 0.5, 95% CI 0.2-0.9), but not at older ages. A significant heterogeneity in risk of B cell lymphoma by age at first contact was detected for contact with cattle, poultry and swine. Early occupational contact with livestock might be associated with a decrease in risk of B cell lymphoma.

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

“…We confirmed prior findings by InterLymph and others with additional cases and controls for a number of exposures. Specifically, we confirmed the previously reported strong increased risk with family history of hematological cancer (10-12), the increased risk with height (18,19), the increased risk with farming exposures (20)(21)(22)(23)(24), and the protective effect of UV radiation on CLL/SLL risk (25,26). Although we report a significant increased risk with hepatitis C virus herein, we had no additional new data beyond that reported in an earlier InterLymph pooled analysis (27).…”

Glyphosate use and associations with non-Hodgkin lymphoma major histological sub-types: findings from the North American Pooled Project

“…A meta-analysis (1) that included these (9, 10) and other studies reported that glyphosate exposure was significantly associated with NHL overall (meta risk ratio (mRR) 1.5, 95% CI 1.1-2.0, N=6 papers). The risk of B-cell lymphoma was mRR 2.0, 95% CI 1.1-3.6 (11,12).…”

“…For example, only three studies (2,9,12) have reported on exposure metrics other than ever or never use. In addition, only three studies have reported any information on risk by NHL sub-type (11,12,18) which have different etiologies (19). Other limitations of previous studies include lack of adjustment for other pesticides.…”

Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

“…46 To our knowledge, there is no study showing that farmers' children have an increased risk of cancer. 47 Our data suggest that not only immunologic danger signals derived from microbes but also non-microbial-associated molecular patterns can be protective environmental exposures. Linear and logistic (*) regression for the association between immunologic markers (target variable) and exposure variables is shown.…”