Lymphomagenesis In Akr Mice: B Cell Lymphomas As A Model Of Tumor Dormancy

Haran-Ghera, Nechama

doi:10.1016/s0065-230x(08)60402-9

Cited by 8 publications

(4 citation statements)

References 125 publications

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“…Though many factors, such as the complex role played by viruses in murine neoplasia, complicate the determination of the relevancy of these models to human cancer, some lymphoma/ leukemias in mice have similarities to the diverse collection of neoplasms grouped under this general heading in humans (21,64,65). Table 4 Several models of lymphoma/leukemia in mice have been suggested as possibly relevant to human B-CLL (66)(67)(68)(69)(70). One of the models described below that has been used to test EMF, the large granular lymphocyte (LGL) rat leukemia transplant model, has been proposed as an appropriate model for human T-CLL (71 Almost all types of human lymphomas have also been observed in mice The distribution of lymphoma tumor types is roughly similar in humans and mice There are age similarities between murine lymphoblastic T-cell lymphoma/leukemia and the analogous childhood and young adult T-cell neoplasms in humans The B/T ratios of lymphomas in human adults and older mice are similar (3-4:1) lnterleukin-6 is involved in the pathogenesis of murine plasmacytoma and human multiple myeloma Similar tumor antigen markers have been observed in both humans and mice Both malignant CD5 B cells in NZB mice and human B-CLL cells express interleukin-10 mRNA Similar cytogenetic changes have been observed in certain lymphomas in humans and mice:…”

Section: Resultsmentioning

confidence: 99%

Assessing the Potential Carcinogenic Activity of Magnetic Fields Using Animal Models

McCann¹,

Kavet²,

Rafferty³

2000

Environmental Health Perspectives

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We update our 1997 publication by reviewing 29 new reports of tests of magnetic fields (MFs) in six different in vivo animal models of carcinogenesis: 2-year, lifetime, or multigeneration exposure studies in rats or mice; and promotion/progression models (rat mammary carcinoma, rat liver focus, mouse skin, several models of human leukemia/lymphoma in rats and mice, and brain cancer in rats). Individual experiments are evaluated using a set of data quality criteria, and summary judgments are made across multiple experiments by applying a criterion of rough reproducibility. The potential for carcinogenicity of MFs is discussed in light of the significant body of carcinogenesis data from animal bioassays that now exists. Excluding abstracts, approximately 80% of the 41 completed studies identified in this and our previous review roughly satisfy data quality criteria. Among these studies, the criterion for independent reproducibility is not satisfied for any positive results but is satisfied for negative results in chronic bioassays in rats and mice and for negative results in both promotion and co-promotion assays using the SENCAR mouse skin model. Results of independent replication studies using the rat mammary carcinoma model were conflicting. We conclude that long-term exposure to continuous 50-or 60-Hz MFs in the range of 0.002-5 mT is unlikely to result in carcinogenesis in rats or mice. Though results of most promotion/progression assays are negative, a weak promoting effect of MFs under certain exposure conditions cannot be ruled out based on available data.

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Section: Resultsmentioning

confidence: 99%

Assessing the Potential Carcinogenic Activity of Magnetic Fields Using Animal Models

McCann¹,

Kavet²,

Rafferty³

2000

Environmental Health Perspectives

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“…Thymectomy of AKR mice effectively prevents T-lymphomagenesis, and instead, B-1 lymphomas develop at a low incidence at ~600 days of age. 7) In contrast, the pre-B lymphomas in SL/Kh are not affected by thymectomy except for slight prolongation of the latency period (Lu, unpublished observation). In SLAKF1, however, thymectomy dramatically changed the type of disease, e.g., from T-to NK1 + B-1 lymphomas.…”

Section: Discussionmentioning

confidence: 99%

“…1,[3][4][5][6] Thymectomy of AKR mice remarkably lowers the lymphoma incidence, modifies the type of lymphomas and prolongs the latent period. 7) In an attempt to characterize the role of the thymus in the action of Tlsm1, we thymectomized (Tx) (SL/ Kh×AKR)F1 mice (SLAKF1) at 1 week of age. In contrast to Tx-AKR mice, Tx-SLAKF1 mice develop lymphomas with the phenotype of CD5 + sIgM + B cells, showing NK-1 expression and large granular lymphocyte (LGL)like morphology at a high incidence and at a relatively short latent period.…”

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confidence: 99%

Mixed Phenotype Lymphomas in Thymectomized (SL/KhxAKR/Ms)F1 Mice

Лу

Hayashi

1999

Japanese Journal of Cancer Research

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Lymphomagenesis in mice is determined both by genetic and epigenetic mechanisms. The inbred strain SL/Kh mice selectively develop pre‐B lymphomas and AKR/Ms, T‐lymphomas. In crosses between SL/Kh and AKR/Ms, an AKR‐derived dominant gene Tlsm1 (Thymic lymphoma susceptible mouse‐1) determines the type of lymphoma to be a T‐lymphoma. As an approach to the role of Tlsm1, we studied the effect of thymectomy at 1 week of age in (SL/KhxAKR/Ms)Fl hybrids. In intact F1 mice, the predominant type of lymphoma was of T‐lineage, whereas in thymectomized mice, it was an unusual mixed‐phenotype lymphoma. They were basically CD5+ B‐lymphomas with a rearranged immunoglobulin gene, but carried NK1 and Mac1 on the cell surface and large lysosomal granules in the cytoplasm. Histologically, the lymphoma consisted of large lymphoblastoid cells and infiltrated the spleen, lymph node and liver. Electron microscopy and histochemistry revealed numerous cytoplasmic granules containing acid phosphatase and lysozyme. These morphological features are suggestive of large granular lymphocytes. They expressed interleukin‐4, perforin, and interferon‐γ. On transplantation, these lymphoma cells grew equally well in intact and thymectomized F1 recipients.

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“…Presumably, hemoblastosis developing in AKR/JY mice during aging is attended by the general adaptation syndrome, which is probably related to circulation of a Gross-type leukosogenic virus [10,12].…”

Section: Methodsmentioning

confidence: 99%

Activity of sympathoadrenal system and myelokaryocyte death during aging in AKR/JY mice

Хлусов¹,

Ставрова²,

Ti³

et al. 2000

Bull Exp Biol Med

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Accelerated bone marrow cell death and activation of the sympathoadrenal system were observed during aging of highly leukemic 2-7-month-old AKR/JY mice compared to that in (CBA/CaLacxAKR/JY)F1 strain. Close correlation was revealed between activity of the sympathoadrenal system and necrotic and apoptotic forms of cell death. This can promote tumor process, because maximum changes in hemopoietic cells occur during advanced stage of the disease.

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Lymphomagenesis In Akr Mice: B Cell Lymphomas As A Model Of Tumor Dormancy

Cited by 8 publications

References 125 publications

Assessing the Potential Carcinogenic Activity of Magnetic Fields Using Animal Models

Assessing the Potential Carcinogenic Activity of Magnetic Fields Using Animal Models

Mixed Phenotype Lymphomas in Thymectomized (SL/KhxAKR/Ms)F1 Mice

Activity of sympathoadrenal system and myelokaryocyte death during aging in AKR/JY mice

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