Lymphomatoid contact dermatitis A syndrome produced by epicutaneous hypersensitivity with clinical features and a histopathologic picture similar to that of mycosis fungoides

Orbaneja, J.Gomez; Diez, L. Iglesias; Lozano, José Luis; Salazar, L. Conde

doi:10.1111/j.1600-0536.1976.tb03012.x

Cited by 116 publications

(42 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since this study did not include cases of eczema, this important aspect will need to be the subject of a separate analysis. 15,16 A previous study by Ardigò et al on the description of RCM findings of discoid lupus suggested the morphologic findings of epidermal disarray and ill-defined cell demarcation as being a variant of spongiosis. 17 While this feature lacks an unequivocal description, there is evidence that this aspect may be comparable to features observed in MF, namely "loss of demarcation," "hole-like perforations," and "epidermal disarray.…”

Section: Discussionmentioning

confidence: 99%

Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

et al. 2012

View full text Add to dashboard Cite

Abstract. Reflectance confocal microscopy (RCM) represents a noninvasive imaging technique that has previously been used for characterization of mycosis fungoides (MF) in a pilot study. We aimed to test the applicability of RCM for diagnosis and differential diagnosis of MF in a clinical study. A total of 39 test sites of 15 patients with a biopsy-proven diagnosis of either MF, parapsoriasis, Sézary syndrome, or lymphomatoid papulosis were analyzed for presence and absence of RCM features of MF. Cochran and Chi 2 analysis were applied to test the concordance between investigators and the distribution of RCM features, respectively. For selected parameters, the Cochran analysis showed good concordance between investigators. Inter-observer reproducibility was highest for junctional atypical lymphocytes, architectural disarray, and spongiosis. Similarly, Chi 2 analysis demonstrated that selected features were present at particularly high frequency in individual skin diseases, with values ranging from 73% to 100% of all examined cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In two reported cases, the dense infiltrate was initially diagnosed as consistent with MF. 8,9 In each case, the correct diagnosis of allergic contact dermatitis was eventually established after positive patch reactions to allergens known to be in contact with the biopsy site were found: the first was a biopsy of hand dermatitis, with an allergy to the striker part of a matchbox, and the second was a biopsy of a left posterior thigh dermatitis, with an allergy to a rubber eraser the patient carried in his back pocket. Ackerman et al also warned that allergic contact dermatitis could closely mimic MF, reporting several cases of spongiotic dermatitis, most often allergic contact dermatitis, with foci of atypical mononuclear cells that he cautioned could be easily misdiagnosed as Pautrier microabscesses.…”

Section: Lymphomatoid Dermatitismentioning

confidence: 99%

Histologic mimickers of mycosis fungoides: a review

Reddy

Bhawan

2006

J Cutan Pathol

View full text Add to dashboard Cite

Mycosis fungoides (MF) is a rare type of non-Hodgkin's lymphoma affecting the skin. Because MF develops slowly over several years and may have a variety of clinical presentations, including itchy patches, plaques or tumors that may be confused with common benign conditions such as eczema and psoriasis, the disease presents a diagnostic challenge. The average time to diagnosis varies but is frequently as long as 3 to 6 years. Skin biopsies frequently reveal nonspecific features of several dermatoses; thus, histologic evaluation of the disease is also challenging. Importantly, various significant and/or benign conditions may mimic MF histologically and result in a misdiagnosis of MF. Here we review the reported histologic mimickers of MF and discuss both similar and differentiating features of each, in order to aid in more accurate interpretation of diagnostically challenging skin biopsies. Clinicopathologic correlation is ultimately essential to make accurate diagnosis of MF and its histologic mimickers.Reddy K, Bhawan J. Histologic mimickers of mycosis fungoides: a review.

show abstract

“…It is the later subacute to chronic ACD, with mild spongiosis, intraepidermal lymphocytes and Langerhans cells, and a bandlike, dermal lymphocytic infiltrate with associated fibrosis that most closely simulates MF (Figure 3, A through C). 20,27,[32][33][34][36][37][38] In these later lesions, scattered, dyskeratotic keratinocytes may be identified. Langerhans cell microabscesses (LCMs), which are evidence of a spongiotic process, are frequently present in the epidermis.…”

Section: -34mentioning

confidence: 99%

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Arps

Chen

Fullen

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, and genetic features must be considered carefully because there are few sensitive and specific clues to the diagnosis. Moreover, an appropriate clinical presentation is essential to the diagnosis and helps to favor or exclude inflammatory/reactive processes. Herein, we discuss 3 important inflammatory dermatoses that may closely simulate mycosis fungoides, and we review the use of ancillary studies in these challenging cases.

show abstract

Lymphomatoid contact dermatitis A syndrome produced by epicutaneous hypersensitivity with clinical features and a histopathologic picture similar to that of mycosis fungoides

Abstract: Four cases have been studied which were clinically suggestive of mycosis fungoides because of their infiltrated plaque-like lesions, but in which the suspicion of a topical hypersensitivity arose when a positive patch test was obtained with the striker part of a box of matches.

Cited by 116 publications

References 1 publication

Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

Histologic mimickers of mycosis fungoides: a review

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Contact Info

Product

Resources

About