Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation

Takeuchi, Kengo; Yokoyama, Masahiro; Ishizawa, Shin; Terui, Yasuhito; Nomura, K.; Marutsuka, Kousuke; Nunomura, Maki; Fukushima, Noriyasu; Yagyuu, Takahiro; Nakamine, Hirokazu; Akiyama, Futoshi; Hoshi, Kazuei; Matsue, Kosei; Hatake, Kiyohiko; Oshimi, Kazuo

doi:10.1182/blood-2010-06-290650

Cited by 109 publications

(136 citation statements)

References 23 publications

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“…102 A subset of patients in one study had a prior history of gastric carcinoma and frequent H.pylori infection. 103 Endoscopic findings include superficial ulceration with surrounding hemorrhage and edema, with some patients showing multifocal involvement of the stomach, small bowel and colon. Luminal masses have not been described and imaging studies show no evidence of lymphadenopathy or organomegaly.…”

Section: Nk-cell Enteropathymentioning

confidence: 99%

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Early lymphoid lesions: conceptual, diagnostic and clinical challenges

et al. 2014

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Section: Nk-cell Enteropathymentioning

confidence: 99%

“…[101][102][103] Patients are either asymptomatic or have non-specific GI symptoms and no history of celiac disease, inflammatory bowel disease or malabsorption. 102 A subset of patients in one study had a prior history of gastric carcinoma and frequent H.pylori infection.…”

Section: Nk-cell Enteropathymentioning

confidence: 99%

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

et al. 2014

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“…The lineage of infiltrated cells is assumed to be NK cells, because they have a CD2?/-and cytoplasmic CD3?, CD4-, CD7?, CD8-, CD56?, TIA1?, granzyme B? phenotype, and the TCR gene rearrangement is polyclonal [64]. Similar indolent proliferations of T cells were reported involving the oral cavity, esophagus, stomach, small intestine, and colon.…”

Section: Indolent T-cell and Nk-cell Lymphoproliferative Diseasesmentioning

confidence: 56%

“…Lymphomatoid gastropathy or NK-cell enteropathy is a nonprogressive NK-cell proliferative lesion of unknown etiology that often regresses spontaneously, even when left untreated. The histological features of these cases include superficial, but confluent, infiltration of medium or large cells, with a moderate-to-abundant clear cytoplasm and a variable proportion of cells with peculiar eosinophilic granules in the cytoplasm [64]. EBER in situ hybridization is always negative, which is an important differential feature from ENKL.…”

Section: Indolent T-cell and Nk-cell Lymphoproliferative Diseasesmentioning

confidence: 99%

“…Indolent T-or NK-cell proliferative diseases, which may be mistaken for aggressive T-cell or NK-cell lymphoma, have been described in the GI tract [63,64]. Lymphomatoid gastropathy or NK-cell enteropathy is a nonprogressive NK-cell proliferative lesion of unknown etiology that often regresses spontaneously, even when left untreated.…”

Section: Indolent T-cell and Nk-cell Lymphoproliferative Diseasesmentioning

confidence: 99%

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Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.Epidemiology T-and NK-cell lymphomas are uncommon: overall, they represent fewer than 25 % of all non-Hodgkin's lymphoma (NHL) [1][2][3]. The occurrence rates of various subtypes of T-and NK-cell lymphomas in Asia are significantly different from those observed in Western countries, and even among Asian countries. The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %). The proportion of T-and NK-cell lymphomas in Taiwan is very low (13.3 %) compared with that of other East Asian countries. Regarding the subtypes of T-and NK-cell lymphomas, two West (Turkey and Iraq) and one South (Pakistan) Asian countries share similar distribution patterns, presenting T lymphoblastic lymphoma (T-LBL) as the most common subtype, followed by peripheral T-cell lymphoma (PTCL) or anaplastic largecell lymphoma (ALCL). The frequency of mycosis fungoides/sezary syndrome (MF/SS) is very high in Kuwait. The distribution patterns of T-and NK-cell lymphomas in Thailand, Taiwan, and Korea are similar, whereas adult T-cell leukemia/lymphoma (ATLL) represents a high proportion of T-and NK-cell lymphomas in Japan. When ATLL is excluded, four countries (Thailand, Taiwan, Korea, and Japan) exhibit very similar patterns of subtype distribution of T-and NK-cell lymphomas. Extranodal NK/ T-cell lymphoma (ENKL) is frequent in China (48 %) and Korea (28.7 %), but is less frequent in Japan (10.4 %), as reported by a recent study performed by an international T-cell project [2]. In China, the frequency of T-or NK-cell lymphoma varies according to geographic region

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