Lymphomatoid Granulomatosis

Lee, Jin Seong; Tuder, Rubin M.; Lynch, David A.

doi:10.2214/ajr.175.5.1751335

Cited by 104 publications

(23 citation statements)

References 14 publications

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“…Internal air-bronchogram can be seen,30 , 31 and the nodule may excavate, disappear, or migrate, which is similar to the behavior found in polyangiitis with granulomatosis. Solitary nodules, alveolar, and reticulonodular opacities may occur, but less frequently.…”

Section: Discussionsupporting

confidence: 59%

“…Typical imaging findings include: multiple, bilateral, peribronchovascular nodules or masses with well- or poorly-defined margins, ranging from 0.5 cm to 10 cm distributed predominantly in the lung bases 2 , 15 , 29 , 30. Internal air-bronchogram can be seen,30 , 31 and the nodule may excavate, disappear, or migrate, which is similar to the behavior found in polyangiitis with granulomatosis.…”

Section: Discussionmentioning

confidence: 82%

“…Solitary nodules, alveolar, and reticulonodular opacities may occur, but less frequently. Mediastinal lymphadenomegaly is found in 25% of cases,15 , 30 , 32 and pleural effusions have been reported in 33% of cases 28. Ground-glass opacities accompanied by signs of pulmonary fibrosis15 as well as pericardial effusion with epicardial mass has already been described 33…”

Section: Discussionmentioning

confidence: 96%

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Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

Campos¹,

Felipe-Silva²,

Zerbini³

et al. 2013

ACR

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Primary lung lymphoma is a rare entity accounting for approximately 0.3% of all primary neoplasia of the lung and includes diffuse large B-cell lymphoma (DLBL) and lymphomatoid granulomatosis (LYG). Considering that clinical features may be similar, whereas epidemiology, morphology, and radiological features are different, the authors report a case of a middle-aged man who presented multiple pulmonary nodules in the lower lobes and ground-glass opacities scattered bilaterally on computed tomography. Clinically, he presented a consumptive syndrome with respiratory failure and pleurisy, which progressed until death. The autopsy findings were consistent with lymphomatoid granulomatosis (LYG) grade 3/ diffuse large B-cell lymphoma (DLBL). The authors call attention to the difficulty of establishing an accurate diagnosis, mainly when the demonstration of EBV-infected atypical B-cells fails.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 96%

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Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

Campos¹,

Felipe-Silva²,

Zerbini³

et al. 2013

ACR

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“…To our knowledge, only one other cases series has studied the CT appearance of pulmonary LG (7). Most descriptions of CT and fluorodeoxyglucose positron emission tomography (FDG-PET) appearance of LG were presented in isolated case reports (8-10).…”

Section: Introductionmentioning

confidence: 99%

Lymphomatoid Granulomatosis: CT and FDG-PET Findings

Chung

Gilman

et al. 2011

Korean J Radiol

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ObjectiveLymphomatoid granulomatosis (LG) is a rare, aggressive extranodal Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease. The purpose of our study was to analyze the CT and fluorodeoxyglucose positron emission tomography (FDG-PET) findings of pulmonary LG.Materials and MethodsBetween 2000 and 2009, four patients with pathologically proven pulmonary LG and chest CT were identified. Two of these patients also had FDG-PET. Imaging features of LG on CT and PET were reviewed.ResultsPulmonary nodules or masses with peribronchovascular, subpleural, and lower lung zonal preponderance were present in all patients. Central low attenuation (4 of 4 patients), ground-glass halo (3 of 4 patients), and peripheral enhancement (4 of 4 patients) were observed in these nodules and masses. An air-bronchogram and cavitation were seen in three of four patients. FDG-PET scans demonstrated avid FDG uptake in the pulmonary nodules and masses.ConclusionPulmonary LG presents with nodules and masses with a lymphatic distribution, as would be expected for a lymphoproliferative disease. However, central low attenuation, ground-glass halo and peripheral enhancement of the nodules/masses are likely related to the angioinvasive nature of this disease. Peripheral enhancement and ground-glass halo, in particular, are valuable characteristic not previously reported that can help radiologists suggest the diagnosis of pulmonary LG.

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“…Pleural effusions (25%) are usually small and present as costophrenic angle blunting. Mediastinal lymphadenopathy is visible on CT in 60% of patients, and nodules are characteristically observed alongside bronchovascular structures and interlobular septa (11,12). The application of FDG-PET for tumor imaging has proved to be highly useful for the diagnosis of primary lung tumors.…”

Section: Discussionmentioning

confidence: 99%

Lymphomatoid granulomatosis involving the central nervous system: A case report and review of the literature

Liu

Chen

et al. 2014

Oncology Letters

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Lymphomatoid granulomatosis (LYG) is a rare tumor with unknown etiology. Specific etiological factors for LYG are also unknown, although previous data indicates that LYG is an Epstein-Barr virus-associated B-cell proliferation associated with an exuberant T-cell reaction. According to the 2008 WHO classification, LYG is characterized by B-cell proliferation of B-lymphoma cells. Generally, treatment options for LYG are similar to those for diffuse large B-cell lymphoma. Unfortunately, LYG is a chemotherapy-resistant disease in certain patients and has a poor prognosis. The current study presents the case of a 19-year-old male patient with pulmonary LYG. The patient exhibited progressive disease following one cycle of chemotherapy with cyclophosphamide, adriamycin, vincristine and prednisone, and nodular lesions in the brain were diagnosed. Radiotherapy was delivered to the whole brain, however, this treatment did not prevent progression of the disease and the patient succumbed three months after initial presentation. An overview of the literature with regard to the etiology, clinical features, diagnosis and treatment options for LYG is also presented in the current case study.

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Lymphomatoid Granulomatosis

Cited by 104 publications

References 14 publications

Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

Lymphomatoid Granulomatosis: CT and FDG-PET Findings

Lymphomatoid granulomatosis involving the central nervous system: A case report and review of the literature

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