Lymphomatoid Granulomatosis with Paraneoplastic Polymyositis: A Rare Malignancy with Rare Complication

Abstract

Lymphomatoid granulomatosis is a rare Epstein-Barr virus driven lymphoproliferative disease. It most commonly presents with symptoms of lung involvement such as cough, chest tightness, and dyspnea or constitutional symptoms of weight loss, malaise, and fever. The diagnosis is obtained by biopsy and histopathology. Here we report the case of a 31-year-old male who presented with weight loss, rash, and weakness and was diagnosed with lymphomatoid granulomatosis with paraneoplastic polymyositis. We explore the relationship of Epstein-Barr virus with inflammatory myopathy and discuss paraneoplastic inflammatory myopathy.

A rare potential cause of mononeuropathy multiplex: LYG Mononeuropathy multiplex

“…10,17,18 Outside of the skin having a similar inflammatory infiltrate but lacking EBER positive atypical B-cells, there is a single case report of a muscle biopsy with similar findings in a patient who presented with a nodular rash and cutaneous ulcerations, significant proximal weakness, and weight loss who was ultimately diagnosed with LYG with presumed paraneoplastic polymyositis. 19 Given the lack of definitive findings described in peripheral nerves, pathologic evaluation of sites outside of the peripheral nervous system remain the definitive diagnostic standard for LYG, even if the primary symptoms are in the peripheral nerves. There are only two additional case reports describing mononeuropathy multiplex in patients ultimately diagnosed with LYG, with both being diagnosed post-mortem.…”