Lymphomatoid papulosis followed by Hodgkin’s disease

Silva, Marcia M.; Morais, José Carlos; Spector, Nelson; Maceira, Juan Piñeiro; Sousa, Maria Auxiliadora Jeunon; Filgueira, Absalom Lima

doi:10.1046/j.1365-4362.1998.00471.x

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Additionally, better understanding of the nature of these disorders has led to expanded immunophenotypic panels for this distinction, with cHL manifesting evidence of a B-cell lineage with expression of PAX5 in most cases. Thus, older reports of cHL following MF or LyP might not be validated using current criteria, (9, 11, 20, 21, 27), perhaps leading to misconceptions regarding a relationship between these conditions. In this report we describe 10 patients with MF or CD30-TLPD who developed nodal disease that resembled cHL; further studies led to final diagnosis of nodal involvement by CD30 positive TCL with Hodgkin-like cells.…”

Section: Discussionmentioning

confidence: 99%

Nodal Involvement by Cutaneous CD30-positive T-cell Lymphoma Mimicking Classical Hodgkin Lymphoma

Éberlé¹,

Song²,

Xi³

et al. 2012

American Journal of Surgical Pathology

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Section: Discussionmentioning

confidence: 99%

Nodal Involvement by Cutaneous CD30-positive T-cell Lymphoma Mimicking Classical Hodgkin Lymphoma

Éberlé¹,

Song²,

Xi³

et al. 2012

American Journal of Surgical Pathology

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“…38,39 The development of an associated lymphoma, in particular MF, anaplastic large-cell lymphoma, or Hodgkin lymphoma occurs in 10%-20% of LyP cases, whereas the risk of lymphoma is not considered to be increased in patients with PL. 16,17,35,36,[40][41][42][43][44][45][46][47][48] The alternative but less accepted concept is that LyP and PL are pathogenically related conditions, perhaps sharing a common etiology such as a virus or other infectious agent. 49 Evidence in support of this hypothesis includes PL and LyP have been reported to occur in the same patient.…”

Section: Discussionmentioning

confidence: 99%

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

Vonderheid¹,

Kadin²,

Gocke³

2011

The American Journal of Dermatopathology

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Pityriasis lichenoides (PL) and lymphomatoid papulosis (LyP) are uncommon idiopathic eruptions with overlapping clinical and histological features. Although current opinion indicates that PL and LyP are distinct and separate entities, molecular genetic evidence of T-cell clonality in both conditions suggests that an etiopathogenic relationship may exist. We report a patient who was diagnosed with LyP type B in 1985 followed by PL after 11 years. We hypothesize that LyP followed by PL in the same patient reflects differences in the host immune response to a common antigenic stimulus.

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“…LyP may be associated with lymphoid malignancies, particularly Hodgkin's disease, mycosis fungoides, and anaplasic T cell lymphomas (2–4). On the other hand, WM may be associated with polycythemia vera (16), lymphomas (17), and Hodgkin's disease (18).…”

Section: Discussionmentioning

confidence: 99%

“…However, although LyP may persist over decades as a recurrent cutaneous disease, the outcome is favorable (1). Lyp may be associated with lymphoid malignancies, particularly Hodgkin's disease, mycosis fungoides, and anaplastic T cell lymphomas (2–4). To the best of our knowledge, there is no report of LyP associated with Waldenström's macroglobulinemia (WM).…”

Section: Introductionmentioning

confidence: 99%

Lymphomatoid Papulosis in a Patient with Waldenström's Macroglobulinemia

Ribeiro‐Silva

Chang

Arruda

et al. 2005

The Journal of Dermatology

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Lymphomatoid papulosis (LyP) is a rare skin disease with a benign course but a malignant histologic appearance based on atypical lymphocytes. Waldenström's macroglobulinemia (WM) is a diffuse infiltration of the bone marrow by cells that synthesize IgM immunoglobulins. A 46-year-old female presented with a two year history of weakness, fatigue, anemia, and recurring multiple erythematous papules and nodules in the skin. The skin biopsy showed pleomorphic lymphoid cells with atypical mitoses permeated by a diffuse dermal infiltrate of normal appearing lymphocytes. The neoplastic cells were positive for CD30, CD3, and CD5 but negative for CD20 and EMA. The bone marrow was hypercellular due to a diffuse infiltration by lymphocytes, plasma cells, and plasmacytoid lymphocytes. LyP is a lymphoproliferative disorder of CD30-positive T cells that may be associated with other lymphoid malignancies, particularly Hodgkin's disease, mycosis fungoides, and anaplastic T cell lymphomas. To our knowledge, this is the first report of a LyP appearing in a patient with WM.

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Lymphomatoid papulosis followed by Hodgkin’s disease

Cited by 12 publications

References 25 publications

Nodal Involvement by Cutaneous CD30-positive T-cell Lymphoma Mimicking Classical Hodgkin Lymphoma

Nodal Involvement by Cutaneous CD30-positive T-cell Lymphoma Mimicking Classical Hodgkin Lymphoma

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

Lymphomatoid Papulosis in a Patient with Waldenström's Macroglobulinemia

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