2016
DOI: 10.1007/s12028-016-0367-2
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Lymphopenia, Infectious Complications, and Outcome in Spontaneous Intracerebral Hemorrhage

Abstract: Background Lymphopenia is increasingly recognized as a consequence of acute illness and may predispose to infections. We investigated whether admission lymphopenia (AL) is associated with increased risk of infectious complications and poor outcome in patients with spontaneous intracerebral hemorrhage (ICH). Methods We retrospectively analyzed a prospectively collected cohort of ICH patients ascertained between 1994 and 2015. We identified subjects with lymphocyte count obtained within 24 h from onset, and AL… Show more

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Cited by 41 publications
(42 citation statements)
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“…Decreased lymphocyte count has been reported to be associated with 90-day mortality (Morotti et al 2017b ) and poor neurological recovery (Giede-Jeppe et al 2016 ) in ICH patients. Lower lymphocyte count in non-survivors identified in the current study is consistent with these previous reports.…”
Section: Discussionmentioning
confidence: 99%
“…Decreased lymphocyte count has been reported to be associated with 90-day mortality (Morotti et al 2017b ) and poor neurological recovery (Giede-Jeppe et al 2016 ) in ICH patients. Lower lymphocyte count in non-survivors identified in the current study is consistent with these previous reports.…”
Section: Discussionmentioning
confidence: 99%
“…Changes in lymphocyte counts during the course of ICH have been reported. Admission lymphocytopenia [ 25 , 26 ] as well as the development of lymphocytopenia during treatment were related to an unfavorable outcome. [ 25 ] Lymphocyte dynamics during the course of TBI have been studied previously.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, the relationship between lipids, inflammation and infections is complex and we were able to adjust our analysis only for admission leukocyte count. Further research efforts are needed to explore the interactions between cholesterol levels and markers of stroke-associated immunodepression and inflammation such as lymphocyte count [19] and C-reactive protein [20].…”
Section: Discussionmentioning
confidence: 99%