Lymphoplasmacytic Sclerosing Pancreatitis and Retroperitoneal Fibrosis

Abstract

Although cases of lymphoplasmacytic sclerosing pancreatitis (LSP) associated with idiopathic retroperitoneal fibrosis have been reported, the association is rare. We describe a 74-year-old man who presented with obstructive jaundice and weight loss. Nineteen months earlier, he had been diagnosed with idiopathic retroperitoneal fibrosis and treated with bilateral ureteric stents. Initial investigations were suggestive of a diagnosis of LSP, however, a malignant cause could not be ruled out. He underwent an exploratory laparotomy and frozen sections confirmed the diagnosis of LSP. An internal biliary bypass was performed using a Roux loop of jejunum, and the patient made an uneventful recovery. This case illustrates the difficulty in distinguishing LSP from pancreatic carcinoma preoperatively.

Retroperitoneal fibrosis: case report and literature review

“…La fibrosis extraperitoneal junto con enfermedades y fenómenos autoinmunes se presenta entre el 8 y 15% de los casos de fibrosis retroperitoneal en forma de fibrosis mediastinal, tiroiditis de Riedel, pseudotumor orbitario fibrótico, periarteritis de las arterias coronarias, nódulos hialinos pulmonares, colangeítis esclerosante, sialoadenitis crónica y fibrosis periarticular 3,4,7,8 . Es menos frecuente la asociación de fibrosis retroperitoneal con lupus eritematoso sistémico, enfermedad de Crohn, artritis, púrpura de Henoch-Schönlein, espondilitis anquilosante, poliarteritis nodosa, granulomatosis de Wegener 14 , arteritis de Takayasu, cirrosis biliar primaria, sarcoidosis, contractura de Dupuytren, enfermedad de Peyronie 1 , enfermedad de Weber-Christian sistémica (paniculitis no supurativa), escleroderma, mesenteritis esclerosante y pancreatitis crónica de origen autoinmune [15][16][17][18] .…”