Lymphoproliferative lesions of the ocular adnexa

Coupland, Sarah E.; Krause, Lothar; Delecluse, Henri Jacques; Anagnostopoulos, Ioannis; Foss, Hans Dieter; Hummel, Michael; Bornfeld, Norbert; Lee, William R.; Stein, Harald

doi:10.1016/s0161-6420(98)98024-1

Cited by 376 publications

(340 citation statements)

References 57 publications

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“…MALT lymphoma is a very indolent lymphoma and remains a localized disease for a long period of time. In our study, only one case (3%) showed extraorbital involvement; this incidence was lower than that of the previous reports (4,6,7).…”

Section: Discussioncontrasting

confidence: 89%

“…In the present study, MALT lymphoma constituted 86% of the classifiable primary ocular adnexal lymphomas. This rate is higher than the 50 -64% rate in previous reports (4,6) but is consistent with the rate reported by a study from Japan (7). This discrepancy possibly reflects the low incidence of follicular lymphoma and chronic lymphocytic lymphoma/leukemia in countries of the far east (15,16).…”

Section: Discussionsupporting

confidence: 89%

“…Some authors have used PCR analysis to detect IgH clonality of ocular adnexal lymphoid lesions (5,6,14,(17)(18)(19)(20), but it is not clear how often PCR reveals the clonality of ocular adnexal MALT lymphomas. We detected a monoclonal B-cell growth in 55% of the cases of MALT lymphoma by using PCR; in general, the PCR technique demonstrates the presence of a monoclonal B-cell population in 25 to 70% of the cases of MALT lymphoma (21).…”

Section: Discussionmentioning

confidence: 99%

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Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

et al. 2001

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Malignant lymphomas and reactive lymphoid hyperplasia (RLH) in the ocular adnexa are sometimes difficult to differentiate morphologically and have often been categorized together as a lymphoproliferative disorder. Immunogenotypic characters of these diseases have not yet been well clarified. This study included 76 cases of ocular adnexal lymphoproliferative disorders. These consisted of 52 cases of malignant lymphoma (43 primary and 9 secondary), 22 of RLH, and 2 borderline cases. There were slightly more male than female subjects. Diagnoses were based on morphology and immunophenotypic characteristics. Clonalities were detected by means of polymerase chain reaction (PCR), and immunoglobulin heavy-chain variable region (VH) genes were sequenced in 10 cases of mucosa-associated lymphoid tissue (MALT) lymphoma. MALT lymphoma constituted 86% (37 cases) of the primary lymphomas. MALT lymphomas were more indolent, more rarely disseminated, and had a lower death rate than the other primary lymphomas. Two patients exhibited coexistence of MALT and diffuse large B-cell lymphoma. The average age of patients with RLH was 5.5 years younger than that of those with MALT lymphoma. One of the cases of RLH later progressed to malignant lymphoma. B-cell clonality was detected by PCR in 57%, 55%, and 0% of primary lymphomas, MALT lymphomas and RLHs, respectively. Sequencing of VH genes revealed that the VH3 family was the most commonly expressed germline VH family (70%) and that DP-63, DP-54 and DP-47 genes were frequently found in the MALT lymphomas examined. PCR analysis was useful for differentiation between MALT lymphoma and RLH. Sequence analysis of VH genes showed that an autoimmune mechanism may be involved in the lymphomagenesis of ocular adnexal MALT lymphoma.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

et al. 2001

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“…Ocular adnexal lymphomas, which arise in the conjunctiva, lacrimal gland, eyelid, and orbital connective tissue, account for 8-12% of all ocular adnexal tumors (3,4), and 8% of all extranodal non-Hodgkin lymphomas (NHL) (5). Although the results of several studies are conflicting, hepatitis C virus (HCV) has been suggested to be a cause of NHL.…”

Section: Introductionmentioning

confidence: 99%

Lacrimal Gland Marginal Zone Lymphoma: Regression after Treatment of Chronic Hepatitis C Virus Infection: Case Report and Review of the Literature

Çoşkun

Yukselen

et al. 2013

Intern. Med.

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A 43-year-old woman was first admitted to the ophthalmology clinic with the complaint of a mass compressing the right eye. Based on clinical and laboratory examinations she was diagnosed as having marginal zone lymphoma (MZL) of the right lacrimal gland in addition to hepatitis C virus (HCV) infection. After the treatment for HCV infection with pegylated interferon plus ribavirin, a radiographic response of the MZL was obtained; she remains in remission through thirty months of clinical follow-up. In this case, the treatment of HCV infection led to regression of MZL suggesting the necessity of testing for HCV infection and treatment of the HCV infection should be highly considered in all HCV-positive patients with MZL's.

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“…Owing to anatomic proximity, nasal NKTL can lead to ocular complications. However, ocular complications in pathologically confirmed cases are rarely reported [5,6].…”

Section: Introductionmentioning

confidence: 99%