Lymphoproliferative Responses to <i>Borrelia burgdorferi</i> in Lyme Disease

Zoschke, David C.; Skemp, Archibald A.; Defosse, D L

doi:10.7326/0003-4819-114-4-285

Cited by 84 publications

(35 citation statements)

References 14 publications

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“…Additionally, in pediatric patients with Lyme arthritis, an increased T cell reactivity to B. burgdorferi whole cell lysate antigen was shown [17]. However, a weak to moderate lymphoproliferative response to B. burgdorferi in some seronegative controls has been observed in this study and by others [28,43]. This might be explained by usage of whole or sonicated B. burgdorferi spirochetes, which contain certain antigens such as heat-shock proteins that share cross-reactive epitopes with antigens of other bacteria [14].…”

Section: Lymphoproliferation To Lysate Antigenscontrasting

confidence: 41%

Characterization of the cellular and humoral immune response to outer surface protein C and outer surface protein 17 in children with early disseminated Lyme borreliosis

Pohl‐Koppe

Kaunicnik

Wilske³

2001

Med Microbiol Immunol

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OspC and Osp17 are immunodominant proteins of Borrelia burgdorferi eliciting a clear humoral immune response in adult patients with systemic Lyme disease. In this study, the cellular immune response to B. burgdorferi and the major outer surface proteins OspC and Osp17 was investigated in children during the course of early disseminated B. burgdorferi infection. Lymphoproliferative responses to recombinant proteins were compared to the protein-specific humoral immune reaction. OspC induced a clear antibody response but elicited an even stronger cellular immune response. In contrast, a cellular as well as humoral immune reaction to Osp17 was only rarely detected. Follow-up examinations demonstrated that the lymphoproliferative response to B. burgdorferi and OspC persisted for several months after antibiotic therapy. Here, we show that in early disseminated Lyme disease of childhood, OspC is a potent antigen influencing both the humoral and cellular immunity, while Osp17 plays only a minor role in immune activation.

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Section: Lymphoproliferation To Lysate Antigenscontrasting

confidence: 41%

Characterization of the cellular and humoral immune response to outer surface protein C and outer surface protein 17 in children with early disseminated Lyme borreliosis

Pohl‐Koppe

Kaunicnik

Wilske³

2001

Med Microbiol Immunol

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“…42–46 Lyme specialty laboratories are favoured by some activists and LLMDs because their nonstandard testing methods and interpretation criteria often lead to more positive results than other laboratories that rely on validated methods. 47 An owner of one such diagnostic company is an ILADS director and an adviser to three Lyme organisations.…”

Section: Unvalidated Laboratory Testingmentioning

confidence: 99%

Antiscience and ethical concerns associated with advocacy of Lyme disease

Auwaerter¹,

Bakken²,

Dattwyler³

et al. 2011

The Lancet Infectious Diseases

106

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Advocacy for Lyme disease has become an increasingly important part of an antiscience movement that denies both the viral cause of AIDS and the benefits of vaccines and that supports unproven (sometimes dangerous) alternative medical treatments. Some activists portray Lyme disease, a geographically limited tick-borne infection, as a disease that is insidious, ubiquitous, difficult to diagnose, and almost incurable; they also propose that the disease causes mainly non-specific symptoms that can be treated only with long-term antibiotics and other unorthodox and unvalidated treatments. Similar to other antiscience groups, these advocates have created a pseudoscientific and alternative selection of practitioners, research, and publications and have coordinated public protests, accused opponents of both corruption and conspiracy, and spurred legislative efforts to subvert evidence-based medicine and peer-reviewed science. The relations and actions of some activists, medical practitioners, and commercial bodies involved in Lyme disease advocacy pose a threat to public health.

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“…Some of the common problems with standardization of test procedures for the diagnosis of Lyme disease have been reviewed (Sigal, 1998b). "Seronegative" Lyme arthritis has been described (Dressler et al, 1991;Zoschke et al, 1991;Holl-Wieden et al, 2007), but it occurs so rarely that vigorous attempts must be undertaken by centers with special experience with Lyme arthritis to exclude other diagnoses. In these cases the cellular immune response induced by B. burgdorferi can be tested (Dressler et al, 1991;Zoschke et al, 1991;Rutkowski et al, 1997).…”

Section: Laboratory Examinationmentioning

confidence: 99%

“…"Seronegative" Lyme arthritis has been described (Dressler et al, 1991;Zoschke et al, 1991;Holl-Wieden et al, 2007), but it occurs so rarely that vigorous attempts must be undertaken by centers with special experience with Lyme arthritis to exclude other diagnoses. In these cases the cellular immune response induced by B. burgdorferi can be tested (Dressler et al, 1991;Zoschke et al, 1991;Rutkowski et al, 1997). However, lymphoproliferative assays are not well standardized and have high rates of false-positive and false-negative results (Dressler et al, 1991;Zoschke et al, 1991;.…”

Section: Laboratory Examinationmentioning

confidence: 99%