Lymphoproliferative tumors involving the lacrimal drainage system: a major review

Singh, Swati; Ali, Mohammad Javed

doi:10.1080/01676830.2019.1634104

Cited by 34 publications

(41 citation statements)

References 68 publications

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“…Most cases involve possible surgical resection, chemotherapy, and/or radiation. This management involved a high success rate with local disease control; however, with systemic disease involvement, 15% died after 18 months [3]. After surgical resection, our patient began receiving chemotherapy treatment and has been stable as of her last office visit.…”

Section: Discussionmentioning

confidence: 99%

“…In the immunocompetent, primary lymphoma occurs at a rate of 0.3% per 100,000 persons [2]. Of all primary lacrimal sac tumors, primary diffuse large B cell lymphoma (DLBCL) occurs at 43%, MALToma at 24%, unclassified B-cell lymphoma at 21%, lymphoid hyperplasia at 5%, and each small lymphocytic lymphoma and natural killer (NK)/T-cell lymphoma at 3% [3]. One of the most common presenting features of DLBCL is dacryocystitis, which is a blockage of the nasolacrimal duct leading to an infection of the lacrimal sac [3].…”

Section: Introductionmentioning

confidence: 99%

“…Of all primary lacrimal sac tumors, primary diffuse large B cell lymphoma (DLBCL) occurs at 43%, MALToma at 24%, unclassified B-cell lymphoma at 21%, lymphoid hyperplasia at 5%, and each small lymphocytic lymphoma and natural killer (NK)/T-cell lymphoma at 3% [3]. One of the most common presenting features of DLBCL is dacryocystitis, which is a blockage of the nasolacrimal duct leading to an infection of the lacrimal sac [3]. The symptoms of DLBCL are usually atypical and nonspecific, which often leads to the original diagnosis with dacryocystitis [4-5].…”

Section: Introductionmentioning

confidence: 99%

“…The symptoms of DLBCL are usually atypical and nonspecific, which often leads to the original diagnosis with dacryocystitis [4-5]. The most presenting features are epiphora (96%), swelling in the lacrimal sac region (75%), and acute dacryocystitis (31%) [3]. Patients with primary lacrimal sac tumors are often older and female [6].…”

Section: Introductionmentioning

confidence: 99%

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An Unusual Presentation of Large B-cell Lymphoma

Robinette

White

2019

Cureus

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Primary Non-Hodgkin's lymphoma of the lacrimal sac is extremely rare. Symptoms are usually atypical and nonspecific, which often leads to the original misdiagnosis of dacryocystitis. The most common presenting features are epiphora, swelling, and acute dacryocystitis. We present a case of a 67-year-old female with primary diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac, which was originally diagnosed as dacryocystitis. This case report adds to the urgency that prompt and precise diagnosis and treatment is key.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Unusual Presentation of Large B-cell Lymphoma

Robinette

White

2019

Cureus

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“…Within the lacrimal drainage system, lymphoma and MALToma are primarily described in the lacrimal sac in humans. 82,92 Periocular Gland-Associated Lymphoid Tissue…”

Section: Lacrimal Drainage-associated Lymphoid Tissuementioning

confidence: 99%

Mucosa-Associated Lymphoid Tissue and Tertiary Lymphoid Structures of the Eye and Ear in Laboratory Animals

Schuh¹

2020

Toxicol Pathol

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Mucosa-associated lymphoid tissue (MALT) of special senses is poorly described and can be confused with nonspecific mononuclear cell infiltrates and tertiary lymphoid structures (TLS). In the eye, MALT consists mostly of conjunctiva-associated lymphoid tissue (CALT) and lacrimal drainage-associated lymphoid tissue (LDALT). In humans, CALT and LDALT are important components of the normal eye-associated lymphoid tissue (EALT), but EALT is less frequently described in ocular tissues of animals. The EALT are acquired postnatally in preferential mucosal sites, expand with antigenic exposure, form well-developed lymphoid follicles, and are reported to senesce. Lymphoid follicles that are induced concurrently with chronic inflammation are more appropriately considered TLS but must be differentiated from inflammation in MALT. Less understood is the etiology for formation of lymphoid tissue aggregates in the ciliary body, limbus, or choroid of healthy eyes in animals and humans. In the healthy eustachian tube and middle ear of animals and humans, MALT may be present but is infrequently described. Concurrent with otitis media, lymphoid follicles in the eustachian tube are probably expanded MALT, but lymphoid follicles in the middle ear may be TLS. The purpose of this comparative review is to familiarize toxicologic pathologists with MALT in the special senses and to provide considerations for differentiating and reporting eye and ear MALT from immune or inflammatory cell infiltrates or inflammation in nonclinical studies, and the circumstances for reporting TLS in compartments of the eye and ear.

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Lacrimal Sac Tumors Imaging

Singh

Ali

2021

Atlas of Orbital Imaging

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Lymphoproliferative tumors involving the lacrimal drainage system: a major review

Cited by 34 publications

References 68 publications

An Unusual Presentation of Large B-cell Lymphoma

An Unusual Presentation of Large B-cell Lymphoma

Mucosa-Associated Lymphoid Tissue and Tertiary Lymphoid Structures of the Eye and Ear in Laboratory Animals

Lacrimal Sac Tumors Imaging

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