Lymphoprotective Effect of Perftoran

Abstract

Experiments on rats showed that the lymphoprotective effect of Perftoran manifests in stimulation of contractile activity of myocytes in the wall and valve cusps of lymphatic microvessels, which in turn activates the pump and capacitive functions of the lymphatic system and improves central lymph outflow. These changes contribute to an increase in the resorption and transport of cell and tissue metabolites from the interstitial space.

Kinin formation in the plasma and cerebral blood flow under conditions of cerebral ischemia/reperfusion in rats during modulation of kinin system activity

“…Injection of contrycal (a polyvalent inhibitor of proteases, including kallikrein [6]) inhibited kininogenesis, which manifested by an increase in PK level (1.8 times) and decrease in KLA in comparison with the control. By contrast, injection of trypsin led to kininogenesis stimulation, which was associated with KLA increase and reduction of PK level in the plasma.…”