Lymphosarcoma in ulcerative colitis

Walker, Frank C.; Weaver, JU

doi:10.1002/bjs.1800510618

Cited by 12 publications

(2 citation statements)

References 3 publications

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“…Other cases of lymphosarcoma involving the colon were described by Cornes et ~1 .~' and by Walker and Weaver. 22 Emanuel and Isbi~te?~ reviewed 21 cases of malignant lymphoma complicating long-standing UC. There were four cases of Hodgkin's disease, six of non-Hodgkin's (in addition to their own reticulum cell sarcoma), and an additional ten that had not been classified into either of these two subgroups.…”

Section: Discussionmentioning

confidence: 99%

Extraintestinal cancers in inflammatory bowel disease

Greenstein

Gennuso

Sachar

et al. 1985

Cancer

196

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The case histories of 1961 patients with inflammatory bowel disease (IBD), 1227 with Crohn's disease (CD) and 734 with ulcerative colitis (UC), have been studied for the incidence of extraintestinal malignant neoplasms. There were 54 extraintestinal cancers in 51 patients: 28 patients with CD and 23 with UC; 25 men and 26 women. There were 9 breast, 7 skin, 15 reticuloendothelial, 11 genitourinary, 3 lung, 3 perianal, 2 pancreatic islet cell, and several miscellaneous cancers. The number of patient-years from the onset of disease to the last date of follow-up was calculated for men and women with each form of IBD. The observed number (O) of neoplasms was recorded. The expected number (E) of neoplasms was derived from the Department of Health, Education, and Welfare (DHEW) incidence figures for the same neoplasms that occurred in a standard age- and sex-matched population. The O/E ratio was then calculated for each type of cancer as well as for the entire series. There were no statistically significant increases in overall O/E ratios of extraintestinal cancers for either CD (0.76) or UC (1.32). On the other hand, several specific types of cancer did appear to occur with a frequency that was significantly greater than expected. These cancers were classified into two groups. The first group included reticuloendothelial neoplasms. There was an excess of leukemias in UC (P less than 0.005) and an excess of lymphomas in both UC and CD (P less than 0.005). The second group included three squamous cell cancers of the perianal region, an incidence 30 times greater than expected, and two squamous cell cancers of the vagina, also in excess of the expected number. Lymphoma, leukemia, and squamous cell cancers have been reported to occur in excess in immunosuppressed or irradiated patients. It may therefore be speculated that the apparently increased incidence of these neoplasms in the patients with ileitis and colitis might be related to immunologic deficiencies associated with IBD, to the long-term administration of steroids or other immunosuppressive medications that were given to most of the patients or, possibly, to increased exposure to ionizing radiation. The apparently increased incidence of perianal and vaginal cancers of the squamous variety might be a consequence of the combined effects of chronic inflammatory disease involving these areas and primary immune suppression.

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Section: Discussionmentioning

confidence: 99%

Extraintestinal cancers in inflammatory bowel disease

Greenstein

Gennuso

Sachar

et al. 1985

Cancer

196

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“…Most emphasis radiologically was placed on a "benign stricture" in the upper sigmoid colon which was not evident either at operation, or on histological examination of the excised specimen. As in most previously reported cases, the diagnosis was established only after microscopic examination of the resected bowel (Walker and Weaver, 1964).…”

Section: Discussionmentioning

confidence: 99%

Chronic Mucosal Ulcerative Colitis With Malignant Lymphoma: Report of a Case

Emanuel

Isbister

1979

Australian and New Zealand Journal of Surgery

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Histiocytic lymphoma in chronic ulcerative colitis

Bashiti

Kraus

1980

Cancer

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Colonic lymphoma and adenocarcinoma occurred together in a man with long-standing ulcerative colitis. The association between lymphoma and ulcerative colitis may be significant since primary colonic lymphomas are very rare. It is suggested that the factors which increase the risk of developing lymphoma of the colon in patients with ulcerative colitis may be the same as those which influence the development of adenocarcinoma, since most of the patients with either neoplasm were in their twenties at the time of onset of ulcerative colitis, the average duration of ulcerative colitis before developing lymphoma or carcinoma was long (12 years), and in most cases, the ulcerative colitis was severe and extensive. In both types of neoplastic disease, an abrupt change in symptoms is the most consistent indication that cancer has developed.Cancer 46:1695-1700, 1980.R I M A R Y LYMPHOMA of the colon and rectum is P very uncommon; Cornes ef ~1 .~ found only 4 cases of lymphosarcoma among 4,595 malignant tumors of the colon at St. Mark's Hospital, a large center for gastrointestinal diseases in London. While the most common neoplasm associated with ulcerative colitis is adenocarcinoma, the less frequent association with lymphoma has received little attention, probably because only 23 cases of primary colonic lymphoma associated with ulcerative colitis have been reThe coincidental occurrence of ulcerative colitis and lymphoma, rare as it is, has prompted speculation that a significant relationship may exist.2 In this report, we present a case of both histiocytic lymphoma and adenocarcinoma of the colon occurring in a man who had had ulcerative colitis for 18 years. ,-ted. Physical examination revealed no lymphadenopathy or hepatosplenomegaly. There was tenderness of the left abdomen with no palpable mass.Proctosigmoidoscopic examination showed multiple masses in the rectosigmoid colon and advanced ulcerative colitis. Results of barium-enema examination were interpreted as indicative of ulcerative colitis involving the entire colon and the terminal ileum. A well defined, irregular, fluoroscopically rigid-appearing, 9-cm segment constricted the mid-descending colon (Fig. 1). Chest x-ray, leukocyte count, and differential and other laboratory data including results of electrocardiogram, and hemoglobin, hematocrit, prothrombin time, and activated partial prothrombin time were interpreted as normal. Bone marrow morphology and differential count were within normal limits. On October 10, 1977, a total proctocolectomy was done. Intraoperatively , the liver, spleen, and periaortic and mesenteric lymph node areas were inspected and palpated and appeared, grossly, to be normal. The patient received multiple-agent chemotherapy (cytoxan, oncovin, procarbazine, and prednisone) and was alive and well 12 months after the colectomy. The operative specimen included the terminal ileum, colon, rectum, and anus. The mucosa of the ileum and colon was flat, finely granular and marked by numerous irregular ulcers. In the region of the descending col...

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Lymphosarcoma in ulcerative colitis

Abstract: CARCINOMA is now becoming a well-known complication of ulcerative colitis, and it is generally recognized that after the disease has been present for ten or more years the incidence of malignant change is of the order of 17 per cent (Slaney and Brooke, 1959).

Cited by 12 publications

References 3 publications

Extraintestinal cancers in inflammatory bowel disease

Extraintestinal cancers in inflammatory bowel disease

Chronic Mucosal Ulcerative Colitis With Malignant Lymphoma: Report of a Case

Histiocytic lymphoma in chronic ulcerative colitis

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