Lymphosarcoma Involving Cranial Nerves in a Cat

Allen, J. G.; Amis, Terence C.

doi:10.1111/j.1751-0813.1975.tb09443.x

Cited by 13 publications

(10 citation statements)

References 4 publications

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“…The gross findings often diverge from the common lymphoma presentation in other organs (Linzmann et al 2009). Lymphoma is the main secondary tumor in the feline CNS and neurolymphomatosis is a rare condition in cats, other animals, and humans (Allen & Amis 1975, Hankenson et al 1998, Kuntzer et al 2000, Mellanby et al 2003, Higgins et al 2008, Choi et al 2013, Shree et al 2016. The neoplastic infiltration in leptomeninges (leptomeningeal lymphomatosis) and perivascular space from medullar parenchyma, as observed in the present study, is a common consequence relative to spinal nerve neurolymphomatosis (Lane et al 1994, Schaffer et al 2012, Mandrioli et al 2012, Rupp et al 2014, Sakurai et al 2016.…”

Section: Discussionsupporting

confidence: 62%

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

et al. 2019

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ISSN 0100-736X (Print) ISSN 1678-5150 (Online) RESUMO.-[Linfoma no sistema nervoso de felinos: aspectos patológicos, imuno-histoquímicos e etiológicos em 16 gatos.] Os aspectos patológicos, imuno-histoquímicos (IHQ) e etiológicos do linfoma envolvendo o sistema nervoso de felinos foram analisados através de um estudo retrospectivo (período de 2004-2017) no Estado do Rio Grande do Sul, Brasil. O envolvimento do sistema nervoso foi observado em 16 (12,2%) dos 125 felinos com linfoma desse estudo e afetou principalmente, jovens com idade mediana de 24 meses. A grande maioria dos casos o linfoma era secundário no sistema nervoso central e somente em três gatos o linfoma foi primário do sistema nervoso. Na IHQ, 14 (87,5%) casos foram positivos para FeLV, seis (37,5%) para FIV, e um foi negativo para ambos. A distribuição do linfoma no sistema nervoso foi em 8/16 felinos na medula espinhal, 7/16 no encéfalo e em 1/16 em nervos e gânglios paravertebrais (neurolinfomatose). Na medula espinhal, o padrão do linfoma foi exclusivamente extradural e frequentemente focal (6/8), localizadas nos segmentos lombares (3/6), sacrais (1/6), torácicos (1/6) e cervicais (1/6). No encéfalo, os padrões neuroanatômicos observados foram: linfomatose leptomeningeal (4/7), coroidite linfomatosa (2/7), linfoma intradural (1/7). ABSTRACT.-Mello L.S., Leite-Filho R.V., Panziera W., Bandinelli M.B., Sonne L., Driemeier D. & Pavarini S.P. 2019. Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats. Pesquisa Veterinária Brasileira 39(6):393-401.

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Section: Discussionsupporting

confidence: 62%

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

et al. 2019

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“…A previous case described macroscopic and histological findings that were very similar to those found in the cat described herein, in particular the infiltration within cranial nerves and roots by neoplastic lymphocytes. 1 In the previous study, 1 the mass from which the lymphomatous proliferation probably started migrating within the roots and Gasserian ganglia, was detected into the pharyngeal region. In the case described herein, it is not possible to hypothesize any site of a nodal origin of lymphoma as, both at the macroscopic and microscopic level, the investigated organs and tissues (with the exception of cranial nerves, cervical spinal roots, and muscles, brain, and meninges) were not affected by the lymphomatous infiltration.…”

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confidence: 85%

“…Feline peripheral nervous system tumors are uncommon, and lymphomas resulting in peripheral nervous system complications are rare, both in animals 1,2 and human beings. 4,5,9 Central and peripheral nervous system lymphomas in human beings, cats and avian species are often associated with neurotropic and oncoviral infections (herpesvirus, retrovirus).…”

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confidence: 99%

A case of feline neurolymphomatosis: pathological and molecular investigations

et al. 2012

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Neurolymphomatosis is a very rare form of nervous system infiltration by lymphoma that can affect cranial and peripheral nerves and spinal nerve roots. The clinical appearance can mimic autoimmune or paraneoplastic neuropathies. To date, only 2 cases of neurolymphomatosis have been reported in the veterinary literature (1 dog and 1 cat). A case of neurolymphomatosis in a 5-year-old female Domestic Shorthair cat is reported. Two, whitish, bosselated, non-symmetric masses (1 cm × 1.2 cm × 0.5 cm) that incorporated almost all cranial nerves and semilunar ganglia occupying the basisphenoid depression were histologically composed of a proliferation of monomorphic lymphocytes. These lymphoid cells were positive for CD3 (T-cell lymphoma). Nested polymerase chain reaction detected feline leukemia provirus. Fragment analysis of feline T-cell receptor (TCR) gene rearrangements evidenced an oligoclonal pattern with few peaks of similar height. The integration of pathologic with biomolecular findings adds to the information concerning the role of Feline leukemia virus on TCRγ rearrangements in cases of feline lymphoma.

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“…3 Lymphoma of the peripheral nerves has been described sporadically and can cause clinical and gross findings that are difficult to be reconciled with the typical appearance of lymphoma in other organs. 4–8 Here we describe the clinical, radiological and pathological findings of a primary, neurotropic B-cell lymphoma in the brachial plexus of a cat and briefly discuss diagnostic approaches and differential diagnoses.…”

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confidence: 99%

A neurotropic lymphoma in the brachial plexus of a cat

Linzmann

Brunnberg

Gruber

et al. 2009

Journal of Feline Medicine and Surgery

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A 7-year-old, intact male domestic shorthair cat was presented with a progressive, non-weight-bearing lameness of the right forelimb. A neurological examination of the patient at the Small Animal Clinic revealed a paralysis of the radial nerve with sustained cutaneous sensation and a hyperaesthetic response. Further clinical, radiological and pathological findings lead to a diagnosis of a primary, neurotropic B-cell lymphoma in the brachial plexus.

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Lymphosarcoma Involving Cranial Nerves in a Cat

Cited by 13 publications

References 4 publications

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

A case of feline neurolymphomatosis: pathological and molecular investigations

A neurotropic lymphoma in the brachial plexus of a cat

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