Lymphosarcomatous arthropathy.

Martin, V M; Bennett, Robert M.; Hughes, G R; Holt, P. J.

doi:10.1136/ard.32.2.162

Cited by 20 publications

(5 citation statements)

References 7 publications

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“…Proposed pathogenetic mechanisms include: infiltration of leukaemic cells into bone or synovial tissue, haemorrhage into the joints secondary to thrombocytopenia, joint infection, gouty arthritis, synovial reaction to periosteal or capsular infiltration and immune complex induced synovitis. 9 In our patient, serum uric acid was found elevated.Synovial immunocytology was not performed in our patients; however few studies on synovial fluids in leukaemia/lymphoma and arthritis have shown variable leucocyte counts and cytologic characteristics. 10 Treatment of acute T-cell lymphoblastic lymphoma/leukemia with renal involvement remains controversial because pathogenetic mechanisms are uncertain.…”

Section: Discussionsupporting

confidence: 47%

T-cell Lymphoblastic Leukaemia/Lymphoma Presenting as Bilateral Renal Enlargement and Arthritis: A Rare Case Report

et al. 2020

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Lymphoma usually presents as painless enlargement of lymph nodes with or without systemic symptoms like fever, weight loss, night sweats, itching and hepatosplenomegaly. But renal enlargement and arthritis as initial manifestations of lymphoma are very uncommon and poses a potential diagnostic challenge. Renal manifestations of lymphoma are usually nonspecific hematuria, fever, flank pain and oliguria. Pathological data are scanty in this regard; few reports indicate that it has a very poor prognosis. Here we described a case of lymphoma presented with bilateral palpable kidneys, pyrexia and arthritis. Initially diagnosis was confused as renal dysfunction was absent and also the condition is rare. However, strong clinical suspicion along with radiological and histopathological evidence as well as immunophenotyping tests helped to diagnose the case as T-cell lymphoblastic leukaemia/lymphoma. J MEDICINE JUL 2020; 21 (2) : 109-112

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Section: Discussionsupporting

confidence: 47%

T-cell Lymphoblastic Leukaemia/Lymphoma Presenting as Bilateral Renal Enlargement and Arthritis: A Rare Case Report

et al. 2020

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“…A recent report described polyarthritis and subcutaneous nodules associated with an aciriar cell carcinoma of the pancreas; the same report cited 13 similar cases (15). The present authors have described a 59year-old woman with an explosive onset of polyarthritis which led to the detection of a widespread lymphosarcoma (16). Although there was extensive bone involvement radiologically, the acute isochronous polyarticular synovitis suggested a generalized systemic aberration rather than a local effect due to the osseous lesions.…”

Section: Discussionmentioning

confidence: 76%

Carcinomatous polyarthritis. The presenting symptom of an ovarian tumor and association with a platelet activating factor

Bennett¹,

Ginsberg²,

Thomsen³

1976

Arthritis & Rheumatism

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A 59-year-old white female presented with an acute polyarthritis, fever, and mental confusion. Accompanying blood changes included positive tests for rheumatoid factor and antinuclear factor, anemia, leukocytosis, thrombocytosis, and a circulating factor that stimulated serotonin release from normal platelets. Exploratory laporatomy for a mobile pelvic mass revealed an adenocarcinoma of the left ovary which was completely resected. Shortly thereafter the patient's acute symptoms subsided. After 2 years of follow-up the patient has remained free of symptoms and the serologic changes have reverted to normal.There is a general awareness that a polyarthritis resembling rheumatoid arthritis can be the initial manifestation of malignancy (1-4). The paucity of reports on this complication of cancer, early recognition of which can save a patient's life, prompted this detailed report of From the Section

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“…Yet, considering the natural history of acute leukemia in children, it is possible that a leukemic blood pattern would have developed if these children had lived longer. A literature search revealed only 4 case reports detailing joint involvement as the initial manifestation of NHL in adults (4,7,21,22). A summary of the clinical and radiographic features of these patients, as well as those of our 2 patients, is given in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Non‐hodgkin's lymphoma of the synovium simulating rheumatoid arthritis

Dorfman

Siegel

Perry

et al. 1987

Arthritis & Rheumatism

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Skeletal involvement in patients with nonHodgkin's lymphoma (NHL) is common, although direct involvement of the joints is unusual. We describe 2 adults who presented with features suggestive of a diagnosis of rheumatoid arthritis, but who were found to have diffuse NHL of the synovium. Results of a review of the literature, and assessment of the few similar cases in which NHL presented in the joint, suggest that the lymphoma may mimic either a monarticular or polyarticular synovitis, without lymphadenopathy or hepatosplenomegaly. Radiographic demonstration of associated bone destruction is the best evidence for non-Hodgkin's lymphomatous arthropathy in patients with rheumatic symptoms.Approximately 7-25% of patients with nonHodgkin's lymphoma (NHL) develop skeletal involvement at some point during their clinical course (1-3). Involvement of the skeletal structure is usually caused by metastasis or, rarely, by primary lymphoma of bone (4). These skeletal lesions may attract clinical attention as a result of pathologic fracture or localized pain and tenderness, although symptoms referable to

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Lymphosarcomatous arthropathy.

Cited by 20 publications

References 7 publications

T-cell Lymphoblastic Leukaemia/Lymphoma Presenting as Bilateral Renal Enlargement and Arthritis: A Rare Case Report

T-cell Lymphoblastic Leukaemia/Lymphoma Presenting as Bilateral Renal Enlargement and Arthritis: A Rare Case Report

Carcinomatous polyarthritis. The presenting symptom of an ovarian tumor and association with a platelet activating factor

Non‐hodgkin's lymphoma of the synovium simulating rheumatoid arthritis

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