Lymphoscintigraphic findings in patients with lipedema

Forner-Cordero, Isabel; Oliván-Sasot, P.; Ruiz-Llorca, C.; Muñoz-Langa, José

doi:10.1016/j.remnie.2018.10.013

Cited by 27 publications

(45 citation statements)

References 21 publications

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“…7,11 Bilancini et al (1995) demonstrated that patients with lipedema have abnormal lymphoscintigraphic profiles and slower lymphatic flow, 11 and a recent prospective study involving 83 women with a diagnosis of lipedema demonstrated the presence of abnormal lymphoscintigraphy findings in 47% of the patient population. 16 While the results of our study support that lymphatic abnormalities may accompany lipedema, our findings are unique in showing that severity of lipedema may be associated with increased impairment of lymphatic transport. It has been suggested that as lipedema progresses, the pressure of fat cells on lymph collectors causes circulatory disturbances at the superficial layers.…”

Section: Discussionsupporting

confidence: 40%

Uncovering Lymphatic Transport Abnormalities in Patients with Primary Lipedema

Gould

El‐Sabawi

Goel

et al. 2019

J reconstr Microsurg

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Background Although lipedema is often clinically distinguished from lymphedema, there is considerable overlap between the two entities. The purpose of this study was to evaluate lymphoscintigraphic findings in patients with lipedema to better characterize lymphatic flow in this patient population. Methods Patients with lipedema receiving lymphoscintigraphy between January 2015 and October 2017 were included. Patient demographics, clinical characteristics, and lymphoscintigraphic findings were extracted. Klienhan's transport index (TI) was utilized to assess lymphatic flow in patient's lower extremities (LEs).Scores ranged from 0 to 45, with values > 10 denoting pathologic lymphatic transport. Results A total of 19 total patients with lipedema underwent lymphoscintigraphic evaluation. Mean age was 54.8 years and mean body mass index was 35.9 kg/m2. Severity of lipedema was classified as stage 1 in five patients (26.3%), stage 2 in four patients (21.1%), stage 3 in four patients (21.1%), and stage 4 in six patients (31.6%). The mean TI for all extremities was 12.5; 24 (63.2%) LEs had a pathologic TI, including 7 LEs with stage 1 (29.2%), 3 LEs with stage 2 (12.5%), 6 LEs with stage 3 (25.0%), and 8 LEs with stage 4 lipedema (33.3%). The mean TI was significantly greater for extremities with severe (stage 3/4) lipedema than those with mild or moderate (stage 1/2) lipedema (15.1 vs. 9.7, p = 0.049). Mean difference in TI scores between each LE for individual patients was 6.43 (standard deviation +7.96). Conclusion Our results suggest that patients with lipedema have impaired lymphatic transport, and more severe lipedema may be associated with greater lymphatic transport abnormalities.

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Section: Discussionsupporting

confidence: 40%

Uncovering Lymphatic Transport Abnormalities in Patients with Primary Lipedema

Gould

El‐Sabawi

Goel

et al. 2019

J reconstr Microsurg

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“…None of the patients demonstrated more severe changes. There was no correlation to the following parameters: age, presence of Stemmer's sign, BMI, or clinical stage of lipedema (Forner‐Cordero, Oliván‐Sasot, Ruiz‐Llorca, & Muñoz‐Langa, ).…”

Section: Edemamentioning

confidence: 90%

Lipedema—An update

Wollina

2018

Dermatologic Therapy

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Lipedema is a chronic disabilitating disease affecting the subcutaneous adipose tissue of the extremities in females during or after puberty. The disease is characterized by bilateral swelling of legs and/or arms, bruising, and pain. In contrast to lymphedema, the most distal parts remain unaffected. In contrast to obesity, patients with lipedema have a lower risk of diabetes mellitus. The pathogenesis is not well understood. However, hormonal factors seem to play a vital role, as it is an exclusively female disorder. The recent advantages in understanding and treating lipedema are reviewed.

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“…The etiology of lipedema remains unclear, with a hormonal and genetic component and hypothetical vasculo-and lympho-angiopathy [6,7,10,11]. A number of studies have aimed to identify a diagnostic tool that would allow for the precise diagnosis of lipedema, such as cutaneous ultrasonography [12], computed tomography [13], magnetic resonance [14], lymphoscintigraphy [15], and tissue sodium content [16]. Researchers have also searched for genetic determinants of lipedema in the hope of identifying genetic tests that would allow for the precise differentiation of lipedema from other diagnoses; however, no such determinants have yet been found [17].…”

Section: Introductionmentioning

confidence: 99%

Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema

2021

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Background Lipedema is a type of subcutaneous adipose tissue disorder that affects mainly women. Its main symptom is bilateral fat accumulation on the extremities with associated pain in the affected areas. Despite growing interest in lipedema among patients and medical health professionals, lipedema is still often misdiagnosed, misunderstood, and mistreated. To promote better understanding of lipedema, we aimed to investigate factors related to the quality of life and describe selected sociodemographic and clinical characteristics of women with lipedema in Poland. Methods We conducted a cross-sectional online survey that was completed by 98 women with lipedema. The participants responded to questionnaires regarding quality of life, sociodemographic and clinical characteristics, and depression symptom severity. Results The participants reported low quality of life and high severity of depressive symptoms. The more severe the symptoms related to pain, heaviness, and swelling, the lower the quality of life. Further analyses showed that depression severity mediated this relationship. Conclusions The current study provides initial information on screening questions, lipedema symptoms, and comorbidities, pointing to the areas needing in-depth investigation. Further steps to improve quality of life in women with lipedema and to reduce health costs should include the education of medical health professionals, using diagnostic tools that allow for differentiation among diagnoses and precise health risk assessment, and creating Polish treatment guidelines for lipedema.

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Lymphoscintigraphic findings in patients with lipedema

Cited by 27 publications

References 21 publications

Uncovering Lymphatic Transport Abnormalities in Patients with Primary Lipedema

Uncovering Lymphatic Transport Abnormalities in Patients with Primary Lipedema

Lipedema—An update

Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema

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