Lymphoscintigraphic Indications in the Diagnosis, Management and Prevention of Secondary Lymphedema

Mango, Lucio

doi:10.3390/radiation3010004

Cited by 2 publications

(1 citation statement)

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“…Traditional lymphoscintigraphy, while considered the gold standard for lymphedema diagnosis, involves patient exposure to ionizing radiation, requires specialized imaging facilities and personnel, and affords only limited spatial resolution of the local lymphatic network[12–14]. This method offers some insight into lymphatic function, as decreased uptake or characteristic distributions of tracer at the endpoint of the study can occur in advanced disease.…”

Section: Introductionmentioning

confidence: 99%

A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics

Razavi,

Ruscic,

Korn

et al. 2024

Preprint

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Despite significant strides in lymphatic system imaging, the timely diagnosis of lymphatic disorders remains elusive. One main cause for this is the absence of standardized, quantitative methods for real-time analysis of lymphatic contractility. Here, we address this unmet need by combining near-infrared lymphangiography imaging with an innovative analytical workflow. We combined data acquisition, signal processing, and statistical analysis to integrate traditional peak-and-valley with advanced wavelet time-frequency analyses. Decision theory was used to evaluate the primary drivers of attributable variance in lymphangiography measurements to generate a strategy for optimizing the number of repeat measurements needed per subject to increase measurement reliability. This approach not only offers detailed insights into lymphatic pumping behaviors across species, sex and age, but also significantly boosts the reliability of these measurements by incorporating multiple regions of interest and evaluating the lymphatic system under various gravitational loads. By addressing the critical need for improved imaging and quantification methods, our study offers a new standard approach for the imaging and analysis of lymphatic function that can improve our understanding, diagnosis, and treatment of lymphatic diseases. The results highlight the importance of comprehensive data acquisition strategies to fully capture the dynamic behavior of the lymphatic system.

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Section: Introductionmentioning

confidence: 99%