Lymphvascular space involvement—A prognostic indicator in endometrial adenocarcinoma

Gal, David; Recio, Fernando O.; Zamurovic, Dragoslava; Tancer, M.Leon

doi:10.1016/0090-8258(91)90334-2

Cited by 88 publications

(43 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is independent of the histological grade or myometrial invasion [18,19]. The presence of vascular invasion causes lymph node metastasis [20]. In our research, lymph node metastases were detected in 56.5% of patients with lymphovascular invasion in the UPSC group and 72.8% of patients with lymphovascular invasion in the CC group.…”

Section: Discussionmentioning

confidence: 58%

Assessment of clinicopathological features, evaluation of treatment, and prognosis of clear cell and serous papillary endometrial carcinoma

Külhan

Kulhan²,

Naykı³

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

Objectives: We aimed to evaluate and compare the clinical and pathological features, diagnosis, treatment, and prognosis of uterine papillary serous carcinoma (UPSC) and clear-cell carcinoma (CC). Material and methods:Thirty-four patients who were operated on for UPSC and CC carcinoma at the İzmir Tepecik Research and Teaching Hospital, between January 1983 and December 2014, were included. Patients were evaluated for the following factors: age, gravidity, parity, preoperative CA-125, tumor size, myometrial and lymphovascular invasion, lymph node tumor metastasis, presence of atypical cells in peritoneal cytology, pathology results, operation types, whether or not they received postoperative adjuvant therapy, prognosis, and death rate. Results:The stage of the disease was the main factor affecting disease-free and the overall survival. Cisplatin-based chemotherapy was partially effective in patients with postoperative recurrence, while postoperative adjuvant radiotherapy proved to be more effective in preventing relapse. Conclusion:The studied parameters generally were concordant with the literature but, due to the relatively small sample size, more comprehensive and multicenter studies are needed to generate valid results.

show abstract

Section: Discussionmentioning

confidence: 58%

Assessment of clinicopathological features, evaluation of treatment, and prognosis of clear cell and serous papillary endometrial carcinoma

Külhan

Kulhan²,

Naykı³

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

show abstract

“…In guter Übereinstimmung mit der Literatur konnte in dieser Untersuchung eine signifikant schlechtere Überlebensprognose bei Vorliegen von Lymphangiosis (Trend) und/oder Hämangiosis carcinomatosa gezeigt werden (Gal et al, 1991;Grulich et al, 1996) Christopherson et al, 1983Christopherson et al, , 1982a. In der Literatur werden nach übereinstimmender Auffassung verschiedene Subtypen des Endometriumkarzinoms mit z.T.…”

Section: Lymphangiosis Und Hämangiosis Carcinomatosaunclassified

Prognosefaktoren des Endometriumkarzinoms - Ein Vergleich klinischer und immunhistochemisch bestimmter Parameter

Brohn¹,

Kullmer²,

Knoblauch³

et al. 2004

Geburtshilfe Frauenheilkd

View full text Add to dashboard Cite

In den meisten Fällen erfolgt die Diagnose Endometriumkarzinom in einem frühen, doch auch in ca. 20 % in einem fortgeschrittenen Stadium. Welche tumorbiologischen Eigenschaften führen dazu, dass einige Endometriumkarzinome erst in fortgeschrittenen Stadien entdeckt werden? Material und Methodik: Ein Kollektiv von 183 Patientinnen mit Karzinomen des Endometriums wurde reevaluiert im Hinblick auf das klinische Follow-up sowie der Histopathologie (myometrane Tumorinvasionstiefe, Tumortyp, Grading, Lymphangiosis und Hämangiosis carcinomatosa, Tumornekrose). Zusätzlich erfolgten immunhistochemische Färbungen zur Detektion der Expression von Östrogen-und Progesteronrezeptor, Fibronektin und Faktor VII aktivierende Protease (FSAP) unter Verwendung der Streptavidin-Biotin-Methode. Mithilfe der Kaplan-Meier-Überlebenszeitanalyse wurden die prognostischen Parameter analysiert; bivariate Korrelationen sowie einfache und schrittweise Diskriminanzanalyse ermöglichten die Analyse der Relevanz der genannten Faktoren im Hinblick auf die Tumorprogression. Ergebnisse: Tumorstadium (FIGO) und Hämangiosis carcinomatosa konnten als wichtigste Prognosefaktoren des Endometriumkarzinoms identifiziert werden. Hinsichtlich der o. g. Fragestellung wurde die Lymphangiosis carcinomatosa als wichtigster

show abstract

“…Vascular invasion is infrequent in endometrioid carcinomas; the frequency of vascular invasion increases with unfavourable cell type, high histological grade, and deep myometrial invasion (24). Nevertheless, the presence of vascular invasion is highly suggestive of lymph node metastases (22,26).…”

Section: Lymphovascularmentioning

confidence: 99%

“…The presence of tumour cells within endothelial-lined spaces is a strong predictor of recurrence and death (22,23). Prat (24) stated that stromal retraction is a frequent artefact that may stimulate vascular invasion.…”

Section: Lymphovascularmentioning

confidence: 99%

Median Survival Time of Endometrial Cancer Patients with Lymphovascular Invasion at the Hospital Universiti Sains Malaysia

Asyikeen

Siti‐Azrin

Jalil

et al. 2016

MJMS

View full text Add to dashboard Cite

show abstract

Lymphvascular space involvement—A prognostic indicator in endometrial adenocarcinoma

Cited by 88 publications

References 17 publications

Assessment of clinicopathological features, evaluation of treatment, and prognosis of clear cell and serous papillary endometrial carcinoma

Assessment of clinicopathological features, evaluation of treatment, and prognosis of clear cell and serous papillary endometrial carcinoma

Prognosefaktoren des Endometriumkarzinoms - Ein Vergleich klinischer und immunhistochemisch bestimmter Parameter

Median Survival Time of Endometrial Cancer Patients with Lymphovascular Invasion at the Hospital Universiti Sains Malaysia

Contact Info

Product

Resources

About