Lyn

Kundur, Sai; Nguyen, Hung; McKee, Lloyd; Cruz, Clairissa; Selvakumar, Ponniah; Lakshmikuttyamma, Ashakumary

doi:10.1007/978-3-319-67199-4_101499

Cited by 2 publications

(2 citation statements)

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“…CUR is a naturally occurring compound derived from plants that exhibit anti-oxidative stress properties. Research studies have reported that CUR effectively attenuates the release of ROS in various experimental settings, including cell lines, preclinical models, and clinical samples (25)(26)(27). Pretreatment with CUR regulates the expression of antioxidant enzymes through nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways to stabilize ROS levels (28).…”

Section: The Anti and Pro-oxidant Properties Of Curcuminmentioning

confidence: 99%

Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis

Peng

et al. 2023

Front. Immunol.

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It has been for thousands of years in China known medicinal homologous foods that can be employed both as foods and medicines to benefit human and animal health. These edible herbal materials perform divert roles in the regulation of metabolic disorders, cancers, and immune-related diseases. Curcumin, the primary component derived from medicinal homologous foods like curcuma longa rhizome, is reported to play vital actions in organic activities, such as the numerous pharmacological functions including anti-oxidative stress, anti-inflammation and anti/pro-apoptosis in treating various diseases. However, the potential mechanisms of curcumin-derived modulation still need to be developed and attract more attention worldwide. Given that these signal pathways are enrolled in important bioactive reactions, we collected curcumin’s last achievements predominantly on the immune-regulation signals with the underlying targetable strategies in the last 10 years. This mini-review will be helpful to accelerate curcumin and other extracts from medicinal homologous foods use in future human clinical applications.

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Section: The Anti and Pro-oxidant Properties Of Curcuminmentioning

confidence: 99%

Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis

Peng

et al. 2023

Front. Immunol.

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“…Комбинации куркумина с различными фитохимическими веществами или лекарственными средствами продемонстрировали усиленные противоопухолевые эффекты на различных моделях злокачественных новообразований человека по сравнению с отдельными препаратами. Например, соединение куркумина с полифенолами -кверцетином [3], ресвератролом [4,5], галлатом эпигаллокатехина [6] или урсоловой кислотой [7] -оказывало синергический ингибирующий эффект на рост и выживание клеток рака толстой кишки, молочной железы и предстательной железы.…”

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DETERMINATION OF THE SYNERGISTIC EFFECT OF CURCUMIN AND CARNOSIC ACID ON THE PROLIFERATION OF PROSTATE CANCER CELLS

Ossikbayeva

2022

Onkol. radiol. Kaz.

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Relevance: Cancer is one of the main causes of death globally. The results of the conducted studies on the energy metabolism of cancer cells can contribute to identifying molecular targets in the treatment of cancer. It is known that polyphenols widely distributed in plants have an anti-cancer effect based on their well-known antioxidant, anti-inflammatory, antiproliferative, proapoptotic, and antiangiogenic potential. Primary prostate cancer treatment methods include surgical resection and chemo- or radiation therapy. In the last decade, polyphenols have attracted attention for use in complex chemotherapy of prostate cancer. The search for natural compounds increasing the body’s resistance to tumor development and reducing the possibility of tumor recurrence after radiation or chemotherapy and the study of their mechanisms of action are relevant directions of further in vivo research. There is a growing interest in studying effective treatment approaches combining drugs with various mechanisms of action. The study aimed to identify the synergistic effect of curcumin and carnosic acid on the proliferation of prostate cancer cells. Methods: The proliferative activity of cells in culture on tablets, under the influence of polyphenols in various concentrations were evaluated by Alamar blue using a BioTek Synergy plate reader (BD Biosciences, San Jose, CA). Conclusion: A detailed evaluation of the data on inhibition of PC3, Du145 cell growth revealed a clear synergistic interaction between curcumin and carnosic acid, which was especially strong at a concentration of curcumin 7 ul in combination with carnosic acid 5 ul

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Lyn

Cited by 2 publications

References 46 publications

Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis

Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis

DETERMINATION OF THE SYNERGISTIC EFFECT OF CURCUMIN AND CARNOSIC ACID ON THE PROLIFERATION OF PROSTATE CANCER CELLS

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