Lynch syndrome type II associated endometrial carcinoma: a case report and literature analysis

Abstract

Lynch syndrome (LS) is an autosomal dominant hereditary disease, which is caused by mismatch repair (MMR) gene mutations in the germline of MLH1, MSH2, MSH6 and PMS2. LS patients can develop colorectal cancer, endometrial cancer (EC), etc, at the same or different time, so their prognosis are poor.