Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading
Zhiyuan Zheng,
Yue Wu,
Ayyaz Ahmad
et al.
Abstract:Lyophilization is a prevalent technique for preparing
paclitaxel
(PTX) clinical formulations. However, the instability of PTX nanoparticles
poses challenges in producing lyophilized formulations. Such an instability
involves maintaining stable dispersions and structural integrity during
lyophilization. To tackle these issues, flash nanoprecipitation method
is employed to prepare highly stable and loaded lyophilizable diPTX-SS
nanoparticles, achieving over a month of nanosuspension stability
and 91 wt % loading… Show more
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