Lys&lt;SUP&gt;3&lt;/SUP&gt;-Bombesin Conjugated to&lt;SUP&gt;99m&lt;/SUP&gt;Tc-Labelled Gold Nanoparticles for &lt;I&gt;In Vivo&lt;/I&gt; Gastrin Releasing Peptide-Receptor Imaging

An, Mendoza-Sánchez; Ferro-Flores, Guillermina; Ocampo‐García, Blanca; Morales-Ávila, Enrique; F, de M Ramírez; León-Rodríguez, De; Santos-Cuevas, Clara; Medina, Luis Alberto; El, Rojas-Calderón; Camacho-López, M.A.

doi:10.1166/jbn.2010.1132

Cited by 48 publications

(71 citation statements)

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“…Various radiolabeled-BnR-agonist probes have been examined for their ability to localize and image the tumor in breast-cancer patients in a few studies (Table 1)[62,76,126–128,128–134]. In 4 women with breast-cancers and seven healthy subjects given the radiolabeled-BnR-agonist, 99m Tc-HYNIC-Lys 3 -Bn)[126], the distribution of the radioligand in normals was examined(kidney>lugs>pancreas> liver>ovaries>bone marrow) and high-uptake in malignant breast-tumors was found.…”

Section: Bn-peptides-bnr: Breast-cancermentioning

confidence: 99%

“…In 4 women with breast-cancers and seven healthy subjects given the radiolabeled-BnR-agonist, 99m Tc-HYNIC-Lys 3 -Bn)[126], the distribution of the radioligand in normals was examined(kidney>lugs>pancreas> liver>ovaries>bone marrow) and high-uptake in malignant breast-tumors was found. In three women with breast-cancers[127] imaging results with 99M Tc-Bn were compared to that with 99m Tc-alone[127] and in all cases the uptake in the tumor was greater with the 99m Tc-labeled-Bn probe,which also imaged lymph node metastases,suggesting possible utility of this approach(Table 1).…”

Section: Bn-peptides-bnr: Breast-cancermentioning

confidence: 99%

“…BnR-agonists conjugated to gold-nanoparticles/nanorods[107,108,126,168] retain high-affinity for GRPR-expressing prostate-cancer-cells and are taken up by the tumor-cells by receptor-mediated-endocytosis[168]. The uptake of the Bn-gold-nanorods by prostate-cancer-cells is clathrin-mediated via clathrin-coated-pits and results in intracellularlysosomal mediated-release of the gold-nanorods[108].…”

Section: Bn-peptides-bnr: Prostate-cancermentioning

confidence: 99%

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Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Moreno

Ramos-Álvarez

Moody

et al. 2016

Expert Opinion on Therapeutic Targets

101

102

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Introduction Despite remarkable advances in tumor treatment, many patients still die from common tumors (breast, prostate, lung, CNS, colon, and pancreas), and thus, new approaches are needed. Many of these tumors synthesize bombesin (Bn)-related peptides and over-express their receptors (BnRs), hence functioning as autocrine-growth-factors. Recent studies support the conclusion that Bn-peptides/BnRs are well-positioned for numerous novel antitumor treatments, including interrupting autocrine-growth via the use of over-expressed receptors for imaging and targeting cytotoxic-compounds, either by direct-coupling or combined with nanoparticle-technology. Areas covered The unique ability of common neoplasms to synthesize, secrete, and show a growth/proliferative/differentiating response due to BnR over-expression, is reviewed, both in general and with regard to the most frequently investigated neoplasms (breast, prostate, lung, and CNS). Particular attention is paid to advances in the recent years. Also considered are the possible therapeutic approaches to the growth/differentiation effect of Bn-peptides, as well as the therapeutic implication of the frequent BnR over-expression for tumor-imaging and/or targeted-delivery. Expert opinion Given that Bn-related-peptides/BnRs are so frequently ectopically-expressed by common tumors, which are often malignant and become refractory to conventional treatments, therapeutic interventions using novel approaches to Bn-peptides and receptors are being explored. Of particular interest is the potential of reproducing BnRs in common tumors, such as the recent success of utilizing overexpression of somatostatin-receptors by neuroendocrine-tumors to provide the most sensitive imaging methods and targeted delivery of cytotoxic-compounds.

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Section: Bn-peptides-bnr: Breast-cancermentioning

confidence: 99%

Section: Bn-peptides-bnr: Breast-cancermentioning

confidence: 99%

Section: Bn-peptides-bnr: Prostate-cancermentioning

confidence: 99%

See 1 more Smart Citation

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Moreno

Ramos-Álvarez

Moody

et al. 2016

Expert Opinion on Therapeutic Targets

101

102

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“…Furthermore, in order to achieve GRP-r imaging, gold NPs were functionalized with Lys 3 -bombesin and radiolabeled with 99m Tc. Biodistribution studies showed maximum tumor uptake of the radiotracer at 1h post-injection [52] .…”

Section: Technetium-99mmentioning

confidence: 97%

“…Therefore, these nanoconstructs could unambiguously be considered as a useful tool in RES theranostics [92]. [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]2018 organs, while in the case of oral administration low-dose distribution to most organs was confirmed, indicating absorption of the nanoconstructs [93].…”

Section: Samarium-153mentioning

confidence: 99%

Radiolabeled Nanoparticles in Nuclear Oncology

2018

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A B S T R A C TDuring recent years, a plethora of pioneering radiolabeled nanoparticles have grown to be an integral part of nuclear medicine as theranostic tools. Herein, we focus on the most representative examples of nanoparticles of the past decade, which have been investigated in conjunction with radioisotopes aiming to serve as drug delivery or imaging agents. The present review highlights the key attributes of each nanosystem and the following classification of radiolabeled nanovehicles is based on increasing mass number (A) of radioisotopic elements.

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Radiolabeling approaches of nanoparticles with ^99mTc

Psimadas

Bouziotis

Georgoulias

et al. 2013

Contrast Media & Molecular

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Nanomedicine applications have recently gathered great attention in terms of their revolutionary properties and multivalency. Nanoparticles (NPs) have proven useful owing to their size, surface and kinetics advantages, as well as their ability to be functionalized with targeting, imaging and therapeutic moieties. Nuclear medicine is actively involved in nano-research innovative breakthrough efforts in multiple applications, through the radiolabeling of NP structures. There are several ways that NP-radiolabeling can be approached depending on the radionuclide that is used and the NP type. The radiolabeling of NPs with the most widely and easily available radiometal, which is (99m) Tc, is the focus of this review.

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Lys<SUP>3</SUP>-Bombesin Conjugated to<SUP>99m</SUP>Tc-Labelled Gold Nanoparticles for <I>In Vivo</I> Gastrin Releasing Peptide-Receptor Imaging

Cited by 48 publications

References 0 publications

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Radiolabeled Nanoparticles in Nuclear Oncology

Radiolabeling approaches of nanoparticles with ^99mTc

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Lys<SUP>3</SUP>-Bombesin Conjugated to<SUP>99m</SUP>Tc-Labelled Gold Nanoparticles for <I>In Vivo</I> Gastrin Releasing Peptide-Receptor Imaging

Cited by 48 publications

References 0 publications

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Radiolabeled Nanoparticles in Nuclear Oncology

Radiolabeling approaches of nanoparticles with 99mTc

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Radiolabeling approaches of nanoparticles with ^99mTc