Lysergic acid diethylamide affects blood flow to specific areas of the conscious rat brain

Goldman, Harold; Fischer, Roland; Nicolov, N; Murphy, Sharon

doi:10.1007/bf01922567

Cited by 11 publications

(1 citation statement)

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“…This hyperfrontality finding is in line with the observation that administration of mescaline, which more specifically acts on 5-HT 2 receptors, resulted in a predominant activation of the frontal cortex during mescaline-induced psychosis (Hermle et al 1993). Significant and marked increases of cerebral blood flow (CBF) after LSD administration also have been found in the frontal and parietal cortices of the conscious rat brain (Goldman et al 1975).…”

Section: Metabolism and Serotoninmentioning

confidence: 99%

Positron Emission Tomography and Fluorodeoxyglucose Studies of Metabolic Hyperfrontality and Psychopathology in the Psilocybin Model of Psychosis

Vollenweider

Leenders

Scharfetter

et al. 1997

Neuropsychopharmacology

378

256

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The effects of the indolehallucinogen psilocybin, a mixed 5-HT2 and 5-HT1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15- or 20-mg dose of psilocybin. Psychotomimetic doses of psilocybin were found to produce a global increase in cerebral metabolic rate of glucose (CMRglu) with significant and most marked increases in the frontomedial and frontolateral cortex (24.3%), anterior cingulate (24.9%), and temporomedial cortex (25.3%). Somewhat smaller increases of CMRglu were found in the basal ganglia (18.5%), and the smallest increases were found in the sensorimotor (14.7%) and occipital cortex (14.4%). The increases of CMRglu in the prefrontal cortex, anterior cingulate, temporomedial cortex, and putamen correlated positively with psychotic symptom formation, in particular with hallucinatory ego disintegration. The present data suggest that excessive 5-HT2 receptor activation results in a hyperfrontal metablic pattern that parallels comparable metabolic findings associated with acute psychotic episodes in chronic schizophrenics and contrasts with the hypofrontality in chronic schizophrenic patients.

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Section: Metabolism and Serotoninmentioning

confidence: 99%