Lysergic acid diethylamide–associated intoxication in Hong Kong: a case series

Li, C; Tang, Magdalene Huen Yin; Chong, YK; Chan, Tina Yc; Mak, Tony Wing Lai

doi:10.12809/hkmj197942

Cited by 3 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although LSD is traditionally classified as a psychedelic and severe toxicity is thought to be rare, significant sympathomimetic features may also result from its abuse. Agitation, violent behaviour, hypertension, tachycardia and rhabdomyolysis after LSD use have been reported in a recent case series in Hong Kong 22 . Another concern in patients presenting with significant toxicities is the possibility of adulteration with other potent hallucinogens such as NBOMes (N‐benzyl‐oxy‐methyl), DOC (dimethoxy‐4‐chloroamphetamine) and DOI (dimethoxy‐4‐iodoamphetamine), which may not be detected routinely by urine toxicology 23 .…”

Section: Interesting Casesmentioning

confidence: 99%

“…Agitation, violent behaviour, hypertension, tachycardia and rhabdomyolysis after LSD use have been reported in a recent case series in Hong Kong. 22 Another concern in patients presenting with significant toxicities is the possibility of adulteration with other potent hallucinogens such as NBOMes (N-benzyl-oxy-methyl), DOC (dimethoxy-4-chloroamphetamine) and DOI (dimethoxy-4-iodoamphetamine), which may not be detected routinely by urine toxicology. 23 The prompt recovery of our case illustrated the importance of treating the sympathomimetic toxicity early in the emergency department.…”

Section: Case 3 -Lsd (Lysergic Acid Diethylamide)mentioning

confidence: 99%

See 1 more Smart Citation

Hong Kong poison information centre: Annual report 2020

Chow

Chan

et al. 2023

Hong Kong j. emerg. med.

View full text Add to dashboard Cite

Background: The Hong Kong Poison Information Centre has provided consultation service to healthcare professionals and collected epidemiological data on poisoning in Hong Kong since 2005. Objective: To analyse and report the poisoning data of Hong Kong Poison Information Centre in 2020 during the COVID-19 pandemic. Methods: A retrospective review of all poisoning cases recorded in the Poison Information and Clinical Management System of Hong Kong Poison Information Centre in 2020. Results: A total of 3633 poisoning cases were analysed. Compared to 2019 (pre-COVID era), there was a reduction of ~10% of total poisoning cases recorded (383 cases), with a majority (> 90%) of reduction from poisoning cases with no clinical effect (353 cases). A greater proportion of reduction was observed among the children (0–12 years), patients with general unintentional poisoning, poisoning due to therapeutic error and food poisoning. An increased number of cases was noted from abusive use, adverse herb/proprietary Chinese medicine reaction and poisoning related to household bleaches. Teenage (13–19 years) poisoning seemed to be unaffected by the COVID-19 pandemic and the previously observed increasing trend continued (up to 11.8% of total poisoning cases this year). Despite a total reduction in poisoning cases recorded, the number of deaths increased by 37% from 35 in 2019 to 48 in 2020 (mortality rate 1.5%). A total of seven interesting cases were discussed. Conclusion: This 15th annual report provides updated epidemiological information on poisoning patterns in Hong Kong during the COVID-19 pandemic. It also highlighted important changes and possible effects of the COVID-19 pandemic on poisoning in Hong Kong in comparison with our previous reports.

show abstract

Section: Interesting Casesmentioning

confidence: 99%

Section: Case 3 -Lsd (Lysergic Acid Diethylamide)mentioning

confidence: 99%

Hong Kong poison information centre: Annual report 2020

Chow

Chan

et al. 2023

Hong Kong j. emerg. med.

View full text Add to dashboard Cite

show abstract

“…Intoxications with LSD are still being recorded (Liakoni et al, 2015;Li et al, 2019). In one series, the highest plasma concentration of LSD during intoxication amounted to 5.9 nM (McCarron et al, 1990).…”

Section: Lysergic Acid Diethylamidementioning

confidence: 98%

Effects of hallucinogenic drugs on the human heart

Neumann,

Dhein,

Kirchhefer

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain. However, a close study reveals that they also act on the heart, possibly increasing the force of contraction and beating rate and may lead to arrhythmias. Here, we will review the inotropic and chronotropic actions of bufotenin, psilocin, psilocybin, lysergic acid diethylamide (LSD), ergotamine, ergometrine, N,N-dimethyltryptamine, and 5-methoxy-N,N-dimethyltryptamine in the human heart.

show abstract

Ergometrine stimulates histamine H 2 receptors in the isolated human atrium

Jacob

Braekow

Hofmann

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction Ergometrine (6aR,9R)-N-((S)-1-Hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or ergonovine) activates several types of serotonin and histamine receptors in the animal heart. We tested the hypotheses that ergometrine might activate human serotonin 5-HT4 receptors (h5-HT4R) and/or human histamine H2 receptors (hH2R) in the heart of transgenic mice and/or in the human isolated atrium. Methods Force of contraction or beating rates were studied in electrically stimulated left atrial or spontaneously beating right atrial preparations or spontaneously beating isolated retrogradely perfused hearts (Langendorff-set up) of mice with cardiac specific overexpression of the h5-HT4R (5-HT4-TG) or of mice with cardiac specific overexpression of the hH2R (H2-TG) or in electrically stimulated human right atrial preparations obtained during cardiac surgery. Western blots to assess phospholamban (PLB) phosphorylation on serine 16 were performed. Results Ergometrine exerted concentration- and time-dependent positive inotropic effects and positive chronotropic effects in atrial preparations starting at 0.3 µM and reaching a plateau at 10 µM in H2-TGs (n = 7). This was accompanied by an increase in PLB phosphorylation at serine 16. Ergometrine up 10 µM failed to increase force of contraction in left atrial preparations from 5-HT4-TGs (n = 5). 10 µM ergometrine increased the force of contraction in isolated retrogradely perfused spontaneously beating heart preparations (Langendorff set-up) from H2-TG but not 5-HT4-TG. In the presence of the phosphodiesterase inhibitor cilostamide (1 µM), 10 µM ergometrine exerted positive inotropic effects in isolated electrically stimulated human right atrial preparations, obtained during cardiac surgery, and these effects were attenuated by 10 µM of the H2R antagonist cimetidine but not by 10 µM of the 5-HT4R antagonist tropisetron. Furthermore, ergometrine showed binding to human histamine H2 receptors (at 100 µM and 1 mM) using HEK cells in a recombinant expression system (pKi < 4.5, n = 3). Conclusion Ergometrine is an agonist at cardiac human H2Rs.

show abstract

Lysergic acid diethylamide–associated intoxication in Hong Kong: a case series

Cited by 3 publications

References 7 publications

Hong Kong poison information centre: Annual report 2020

Hong Kong poison information centre: Annual report 2020

Effects of hallucinogenic drugs on the human heart

Ergometrine stimulates histamine H 2 receptors in the isolated human atrium

Contact Info

Product

Resources

About