Lysine-block-tyrosine block copolypeptides: Self-assembly, cross-linking, and conjugation of targeted ligand for drug encapsulation

Huang, Yun Chiao; Yi-ming, Yang; Lai, Tzu Yu; Jan, Jeng‐Shiung

doi:10.1016/j.polymer.2012.01.010

Cited by 39 publications

(26 citation statements)

References 51 publications

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“…Huang et al reported saccharide‐decorated amphiphilic block copolymers via post‐polymerization functionalization . The poly( l ‐lysine)‐ block ‐poly( l ‐tyrosine) copolymers were capable of forming both micelles and vesicles, which could be crosslinked by UV irradiation via dimerization of the tyrosine residues thus increasing the biostability.…”

Section: Functionalization For Active Targeting and Promotion Of Cellmentioning

confidence: 99%

Recent advances in drug delivery systems based on polypeptides prepared fromN-carboxyanhydrides

Hehir

Cameron

2014

Polym. Int.

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Recent years have seen a dramatic increase in interest in the use of ring-opening polymerization of N-carboxyanhydride (NCA) monomers as a method to prepare well-defined polypeptides and peptide-hybrid materials. The resulting molecules are often capable of assembling into a variety of different structures, including micelles, vesicles, nanoparticles and hydrogels, and therefore have been explored as novel drug delivery systems. Peptides are attractive in this regard due to their rich chemical functionality and ability to assemble through the formation of secondary structures (for example -helices and -sheets). In addition, they are inherently biodegradable and biocompatible. This review describes recent advances in the field, covering aspects such as improved methods with which to prepare better-defined polypeptides, crosslinking of assemblies to enhance biostability, the preparation of materials that respond to a variety of stimuli (including light and intra-or extracellular redox conditions), functionalization with targeting ligands to enhance cellular uptake, assemblies for siRNA delivery and approaches to theranostic systems.3

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Section: Functionalization For Active Targeting and Promotion Of Cellmentioning

confidence: 99%

Recent advances in drug delivery systems based on polypeptides prepared fromN-carboxyanhydrides

Hehir

Cameron

2014

Polym. Int.

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“…Since then, this strategy has been exploited by a number of other groups [28–33]. Covalent cross-links between specific domains of the micelles are formed in order to improve the micelles’ structural stability suitable to drug delivery rather than the weak non-covalent intermolecular hydrophobic interactions existing in the conventional polymeric micelles that facilitate polymer micelles assembly and integrity [27].…”

Section: Introductionmentioning

confidence: 99%

“…To be more effective, anticancer drugs should be released exclusively in tumor tissue or inside tumor cell. However, excessively stabilized micelles may prevent the drug from releasing to target sites, thus reducing the therapeutic efficacy [28, 29]. Stimuli-responsive cross-linked micelles (SCMs) are introduced to improve the drug delivery [30–33].…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Xiao

Zhu

et al. 2014

Advanced Drug Delivery Reviews

270

167

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Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-crosslinked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive crosslinkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.

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“…Because radical polymerization 14) and polycondensation 14) aren't available in many case. Various encapsulation by self-assembly has been carried out by the formation of micelles, vesicles, nanoparticles, nanospheres or nanogels by polyion complex, 15,16) a pair of copolymers, 17) amphiphilic block copolymers, [18][19][20][21] graft copolymers, 22) amphiphilic protein, 23) or cholesterol-bearing pullulan 24) in an aqueous solution. But there has been no previous report on the encapsulation by commonly available homopolymer like poly(methyl methacrylate) (PMMA), which is too hydrophobic and precipitates immediately in an aqueous solution.…”

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confidence: 99%

“…The method using PMMA may be a novel example among various encapsulation by self-assembly hitherto reported. [15][16][17][18][19][20][21][22][23][24] Since VC is unstable in oxidation, little attention has been paid to the encapsulation of it by radical polymerization which is simple and convenient. The encapsulation by microsuspension polymerization utilizing the self-assembling of phase separated polymer (SaPSeP) method in oil-in-water (O/W) emulsion was developed by Okubo et al 26,27) and applied to the preparation of capsule particles for cosmetic.…”

mentioning

confidence: 99%

Microencapsulation of Ascorbic Acid for Cosmetic by Utilizing Self-assembly of Phase Separated Polymer

Nakai

Michida

2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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Micrometer-sized polymer particles encapsulated ascorbic acid (vitamin C; VC) were successfully prepared by the three types of the self-assembling method, those are, phase separation and self-assembly of added polymer at the oil-water interface in emulsion, microsuspension polymerization utilizing the selfassembling of phase separated polymer (SaPSeP) method, and their hybrid method. In the stability study at 50°C for 2 months, the three kinds of capsule particles exhibited effective protection of VC from the interaction with other components in cosmetic consisting of water-in-oil (W/O) emulsion. The encapsulated VC was easily released from the capsule particles by an excess of water. These encapsulation methods will be useful for the stabilization of water-soluble substances in cosmetic consisting of W/O emulsion.

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Lysine-block-tyrosine block copolypeptides: Self-assembly, cross-linking, and conjugation of targeted ligand for drug encapsulation

Cited by 39 publications

References 51 publications

Recent advances in drug delivery systems based on polypeptides prepared fromN-carboxyanhydrides

Recent advances in drug delivery systems based on polypeptides prepared fromN-carboxyanhydrides

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Microencapsulation of Ascorbic Acid for Cosmetic by Utilizing Self-assembly of Phase Separated Polymer

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